Abstract: A shaker screen including a composite frame, a removable grid attached to the composite frame, and at least one filtering element attached to the removable grid is disclosed. A method including forming a composite frame, forming a removable grid, attaching at least one filtering element to the removable grid, and attaching the removable grid to the composite frame is disclosed. Additionally, a method for rebuilding a shaker screen, the method including removing a first screen assembly from a composite frame, the screen assembly having a removable grid and at least one filtering element, and attaching a second screen assembly to the composite frame is disclosed.

Abstract: A method of manufacturing two screens in a jig by laying a length of woven wire cloth across two rectangular frames laid side by side in the jig with longer edges abutting, and orientating the cloth so that the warp wires extend continuously across the two screens. The cloth is tensioned and bonded to the frames after which it is severed along the join and surplus cloth is trimmed away from the edges of the frame. If the cloth has a square mesh and the warp wires are of greater cross-section than the weft wires, the warp wires will extend across the width of the frame, and if the cloth has a rectangular mesh, the greater number of warp wires per unit length also extends across the width of the frame. In each case warp wires will resist the stresses across the width of the central region of each opening.

Abstract: The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional regulatory nucleic acid molecule from the human CYP3A4 gene located between the initiation of transcription site of the gene and a position located 13,000 nucleotides upstream from the site. The invention also relates to the use of these animals for determining the effect of a compound, particularly, but not exclusively, a xenobiotic or steroid, on the regulation of expression of the CYP3A4 gene in a human.

Abstract: A method of manufacturing two screens in a jig by laying a length of woven wire cloth across two rectangular frames laid side by side in the jig with longer edges abutting, and orientating the cloth so that the warp wires extend continuously across the two screens. The cloth is tensioned and bonded to the frames after which it is severed along the join and surplus cloth is trimmed away from the edges of the frame. If the cloth has a square mesh and the warp wires are of greater cross-section than the weft wires, the warp wires will extend across the width of the frame, and if the cloth has a rectangular mesh, the greater number of warp wires per unit length also extends across the width of the frame. In each case warp wires will resist the stresses across the width of the central region of each opening.

Abstract: A screen is described for use in a vibrating machine for separating solids from liquid material, comprising woven wire cloth of orthogonal warp and weft wires, tensioned and bonded to a support structure defining at least one rectangular opening across which the cloth extends. The orientation of the cloth is chosen so that the warp wires extend across the width (i.e. shorter dimension) of the opening(s). If the cloth has a square mesh and the warp wires are of greater cross section than the weft wires, the warp wires will extend across the width of the frame, and if the cloth has a rectangular mesh, the greater number of warp wires per unit length will also extend across the width of the frame, so that in each case warp wires will resist in use the stresses across the width of the central region of the or each opening.

Abstract: The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional regulatory nucleic acid molecule from the human CYP3A4 gene located between the initiation of transcription site of the gene and a position located 13,000 nucleotides upstream from the site. The invention also relates to the use of these animals for determining the effect of a compound, particularly, but not exclusively, a xenobiotic or steroid, on the regulation of expression of the CYP3A4 gene in a human.

Abstract: The invention relates to a screen frame adapted for use in a shaker and to which woven wire mesh is to be attached, comprising an outer perimeter and a plurality of plastics ribs extending between opposing regions of the perimeter, the frame being arranged such that, when fitted in a shaker to which it is adapted for, a portion of the opposing regions is clamped in place and a portion of the opposing regions is not clamped with the number of plastics ribs per unit length for the clamped portion greater than the number of plastics ribs per unit length for the unclamped portion, and to a shaker comprising at least one such screen frame.

Abstract: The invention relates to a screen frame adapted for use in a shaker to separate solids from a liquid/solid mixture and to which woven wire mesh is to be attached, comprising an outer perimeter and a plurality of plastics ribs extending between opposing regions of the perimeter, the plastics ribs together forming an upper face and a lower face, wherein the frame further comprises at least one metal rib extending between opposing regions of the perimeter and extending from the upper face to the lower face, and to a shaker comprising at least one such screen frame.

Abstract: There is provided a screen frame adapted for use in a shaker to separate solids from liquid/solid mixture and to which woven wire mesh is to be attached, comprising a plurality of intersecting elongate members (12) defining a plurality of openings (10), or cells, wherein at least one protrusion (26) in the form of an elongate rib extends partway across each opening (10).

Abstract: A hookstrip screen assembly for use in a shaker is disclosed. The hookstrip screen assembly includes a filtering element and a composite frame further including a top surface, a bottom surface, and a plurality of filtering element attachment points. Also, the filtering element is attached to the plurality of filtering element attachment points. In another aspect, a method of forming a hookstrip screen assembly for use in a shaker. The method of forming a hookstrip screen assembly includes forming a wire structure, molding a composite frame incorporating the wire structure and forming a plurality of filtering element attachment points on the composite frame. The method also includes attaching a filtering element to the plurality of filtering element attachment points on the composite frame.

Abstract: The invention relates to a screen frame adapted for use in a shaker to separate solids from a liquid/solid mixture and to which woven wire mesh is to be attached, comprising an outer perimeter and a plurality of ribs extending between opposing regions of the perimeter, the ribs defining an upper horizontal face to which a screen is to be attached, wherein at least one rib extends downwardly from the upper face at an angle off set to vertical, and to a shaker comprising at least one such screen frame.

Abstract: A method of forming a shaker screen includes forming a frame, and attaching a first sealing element to at least one side of an outer perimeter of the frame, wherein the attaching comprises aligning a first mating surface of the frame to a second mating surface of the first sealing element, and wherein the first mating surface of the frame includes an extension, and the second mating surface of the first sealing element includes a groove configured to align with the extension. A system of sealing shaker screens includes a first screen and a second screen disposed adjacent the first screen, wherein a first sealing element of a first frame and a portion of the second screen interact to provide a seal between the first screen and the second screen.

Abstract: A system including a first screen having a first frame and a first sealing element attached to an outer perimeter of the first frame, and a second screen disposed adjacent the first screen, the second screen having a second frame and a second sealing element attached to an outer perimeter of the second frame, wherein the first sealing element and the second sealing element provide a seal between the first screen and the second screen is disclosed. Further, a method of forming a screen frame including forming a frame and attaching a sealing element to an outer perimeter of the frame is disclosed. Additionally, a shaker screen including a frame and a sealing element attached to an outer perimeter of the frame, wherein the sealing element is attached by one selected from thermal bonding and co-molding is disclosed.

Abstract: Abstract: A shaker screen for attachment to a bed of a shaker includes a screen frame having at least one mesh screen attached to the top side of the screen frame, wherein the screen frame is preferentially bowed prior to attaching the mesh screen to the screen frame.

Abstract: A vibratory separator including a screen frame and a screen attachment. The screen attachment including at least one vertically disposed latch on the screen frame, at least one vertically disposed catch on the screen frame, and at least one bearing surface proximate the at least one vertically disposed catch. Additionally, a method of securing adjacent screens including inserting a vertically disposed latch of a first screen into a catch of a second screen, wherein the inserting includes contacting the latch of the first screen with a bearing surface of the second screen adjacent the catch of the second screen. The method further includes forming a planar alignment of the first screen to the second screen.

Abstract: There is provided a plug for repairing a sifting or filtering screen, the plug comprising a body (1) of a first material supporting an area of a second material which is more resilient than the first material, in use the area of a second material serving as a seal (2) to engage and seal against the screen in order to plug a cell aligned with a damaged area of the screen. A second plug has a body (101) formed with holes (108) to receive securing members such as screws, the holes being positioned to enable the securing members (109) to pass into the material of the sifting or filtering screen in order releasably to secure the plug in a cell aligned with a damaged area of the sifting screen.

Abstract: The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional regulatory nucleic acid molecule from the human CYP3A4 gene located between the initiation of transcription site of the gene and a position located 13,000 nucleotides upstream from the site. The invention also relates to the use of these animals for determining the effect of a compound, particularly, but not exclusively, a xenobiotic or steroid, on the regulation of expression of the CYP3A4 gene in a human.

Abstract: The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional regulatory nucleic acid molecule from the human CYP3A4 gene located between the initiation of transcription site of the gene and a position located 13,000 nucleotides upstream from the site. The invention also relates to the use of these animals for determining the effect of a compound, particularly, but not exclusively, a xenobiotic or steroid, on the regulation of expression of the CYP3A4 gene in a human.

Abstract: The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional regulatory nucleic acid molecule from the human CYP3A4 gene located between the initiation of transcription site of the gene and a position located 13,000 nucleotides upstream from the site. The invention also relates to the use of these animals for determining the effect of a compound, particularly, but not exclusively, a xenobiotic or steriod, on the regulation of expression of the CYP3A4 gene in a human.

Abstract: A shaker screen including a composite frame, a removable grid attached to the composite frame, and at least one filtering element attached to the removable grid is disclosed. A method including forming a composite frame, forming a removable grid, attaching at least one filtering element to the removable grid, and attaching the removable grid to the composite frame is disclosed. Additionally, a method for rebuilding a shaker screen, the method including removing a first screen assembly from a composite frame, the screen assembly having a removable grid and at least one filtering element, and attaching a second screen assembly to the composite frame is disclosed.