Abstract: A device and method for precisely positioning a probe tip relative to a target lesion in a bodily protuberance is provided. The protuberance to be probed is secured between a first and a second radiolucent platform. The platforms are in parallel and spaced relation and the second platform comprises a plurality of passages for insertion of a probe. Radiopaque markers on the second platform aid in locating the lesion in a radiograph of the target taken along a first path through the second platform, target and first platform. Utilizing the radiograph, a probe guide comprising a plurality of passages is positioned immediate the lesion to enable the positioning of a probe coincident the lesion along the first path. A radiopaque scale is positioned coplanar the probe guide to indicate distance along the first path enabling the creation of a second radiograph indicating the depth of the lesion relative to the probe guide and the radiopaque scale.