Patents by Inventor Grayson B. Lipford

Grayson B. Lipford has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TOLEROGENIC SYNTHETIC NANOCARRIERS
    Publication number: 20240156955
    Abstract: This invention relates, at least in part, to compositions comprising synthetic nanocarriers and immunosuppressants that result in immune suppressive effects. Such compositions can further comprise antigen and provide antigen-specific tolerogenic immune responses.
    Type: Application
    Filed: June 6, 2023
    Publication date: May 16, 2024
    Applicant: Selecta Biosciences, Inc.
    Inventors: Christopher Fraser, Grayson B. Lipford, Christopher J. Roy, Roberto A. Maldonado
  • Tolerogenic synthetic nanocarriers
    Patent number: 11717569
    Abstract: This invention relates, at least in part, to compositions comprising synthetic nanocarriers and immunosuppressants that result in immune suppressive effects. Such compositions can further comprise antigen and provide antigen-specific tolerogenic immune responses.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: August 8, 2023
    Assignee: Selecta Biosciences, Inc.
    Inventors: Christopher Fraser, Grayson B. Lipford, Christopher J. Roy, Roberto A. Maldonado
  • NANOCARRIERS POSSESSING COMPONENTS WITH DIFFERENT RATES OF RELEASE
    Publication number: 20200390881
    Abstract: This invention relates to compositions, and related methods, of synthetic nanocarriers that comprise immunomodulatory agents and antigens that are differentially released from the synthetic nanocarriers.
    Type: Application
    Filed: January 27, 2020
    Publication date: December 17, 2020
    Applicant: Selecta Biosciences, Inc.
    Inventors: Grayson B. Lipford, Charles Zepp, Yun Gao, Mark J. Keegan, Sam Baldwin, Fen-ni Fu, Lloyd Johnston
  • Immune system modulators
    Patent number: 10117875
    Abstract: The present invention relates to a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same; and a method for treating or preventing autoimmunity disease using the same.
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: November 6, 2018
    Assignee: JANUS BIOTHERAPEUTICS, INC.
    Inventors: Grayson B. Lipford, Charles M. Zepp
  • IMMUNOMODULATORY AGENT-POLYMERIC COMPOUNDS
    Publication number: 20180256709
    Abstract: This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.
    Type: Application
    Filed: February 5, 2018
    Publication date: September 13, 2018
    Applicant: Selecta Biosciences, Inc.
    Inventors: Charles Zepp, Grayson B. Lipford, Yun Gao, Lloyd Johnston, Fen-ni Fu, Mark J. Keegan, Sam Baldwin
  • DOSE SELECTION OF ADJUVANTED SYNTHETIC NANOCARRIERS
    Publication number: 20180043023
    Abstract: Disclosed are synthetic nanocarrier compositions with coupled adjuvant compositions as well as related methods.
    Type: Application
    Filed: August 23, 2017
    Publication date: February 15, 2018
    Applicant: Selecta Biosciences, Inc.
    Inventors: Petr Ilyinskii, Grayson B. Lipford, Charles Zepp
  • Immunomodulatory agent-polymeric compounds
    Patent number: 9884112
    Abstract: This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: February 6, 2018
    Assignee: Selecta Biosciences, Inc.
    Inventors: Charles Zepp, Grayson B. Lipford, Yun Gao, Lloyd Johnston, Fen-ni Fu, Mark J. Keegan, Sam Baldwin
  • Imidazole quinoline-based immune system modulators
    Patent number: 9873694
    Abstract: The present invention relates to a compound of Formula I: or an enantiomer, diastereomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same; and a method for treating or preventing autoimmunity disease using the same.
    Type: Grant
    Filed: October 3, 2012
    Date of Patent: January 23, 2018
    Assignee: JANUS BIOTHERAPEUTICS, INC.
    Inventors: Grayson B. Lipford, Charles M. Zepp
  • IMMUNONANOTHERAPEUTICS PROVIDING A TH1-BIASED RESPONSE
    Publication number: 20170349433
    Abstract: Disclosed are synthetic nanocarrier compositions, and related methods, for treating diseases in which generating a Th1-biased immune response is desirable.
    Type: Application
    Filed: June 22, 2017
    Publication date: December 7, 2017
    Applicant: Selecta Biosciences, Inc.
    Inventors: Grayson B. Lipford, Robert L. Bratzler
  • NOVEL N2, N4, N7, 6-TETRASUBSTITUTED PTERIDINE-2,4,7-TRIAMINE AND 2, 4, 6, 7-TETRASUBSTITUTED PTERIDINE COMPOUNDS AND METHODS OF SYNTHESIS AND USE THEREOF
    Publication number: 20170275287
    Abstract: Compounds as immune system modulators bearing a pteridine core are described. A pharmaceutical composition comprising the same, methods of making the same, and a method for treating or preventing autoimmunity disease using the same are described.
    Type: Application
    Filed: August 21, 2015
    Publication date: September 28, 2017
    Applicant: Janus Biotherapeutics, Inc.
    Inventors: Grayson B. LIPFORD, Charles M. ZEPP
  • Dose selection of adjuvanted synthetic nanocarriers
    Patent number: 9764031
    Abstract: Disclosed are synthetic nanocarrier compositions with coupled adjuvant compositions as well as related methods.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: September 19, 2017
    Assignee: Selecta Biosciences, Inc.
    Inventors: Petr Ilyinskii, Grayson B. Lipford, Charles Zepp
  • NOVEL IMMUNE SYSTEM MODULATORS
    Publication number: 20170224699
    Abstract: The present invention relates to a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same; and a method for treating or preventing autoimmunity disease using the same.
    Type: Application
    Filed: April 3, 2017
    Publication date: August 10, 2017
    Inventors: Grayson B. LIPFORD, Charles M. ZEPP
  • Immune system modulators
    Patent number: 9637489
    Abstract: The present invention relates to a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same; and a method for treating or preventing autoimmunity disease using the same.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: May 2, 2017
    Assignee: JANUS BIOTHERAPEUTICS, INC.
    Inventors: Grayson B. Lipford, Charles M. Zepp
  • Immunostimulatory G, U-containing oligoribonucleotides
    Patent number: 9428536
    Abstract: Compositions and methods relating to immunostimulatory RNA oligomers are provided. The immunostimulatory RNA molecules are believed to represent natural ligands of one or more Toll-like receptors, including Toll-like receptor 7 (TLR7) and Toll-like receptor 8 (TLR8). The compositions and methods are useful for stimulating immune activation. Methods useful for screening candidate immunostimulatory compounds are also provided.
    Type: Grant
    Filed: January 21, 2014
    Date of Patent: August 30, 2016
    Assignee: Zoetis Belgium SA
    Inventors: Grayson B. Lipford, Stefan Bauer, Hermann Wagner
  • TOLEROGENIC SYNTHETIC NANOCARRIERS
    Publication number: 20160243253
    Abstract: This invention relates, at least in part, to compositions comprising synthetic nanocarriers and immunosuppressants that result in immune suppressive effects. Such compositions can further comprise antigen and provide antigen-specific tolerogenic immune responses.
    Type: Application
    Filed: February 22, 2016
    Publication date: August 25, 2016
    Inventors: Christopher Fraser, Grayson B. Lipford, Christopher J. Roy, Roberto A. Maldonado
  • Immune system modulators
    Patent number: 9359361
    Abstract: The present invention relates to a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same; and a method for treating or preventing autoimmunity disease using the same.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: June 7, 2016
    Assignee: JANUS BIOTHERAPEUTICS, INC.
    Inventors: Grayson B. Lipford, Charles M. Zepp
  • Immune system modulators
    Patent number: 9353115
    Abstract: The present invention relates to a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same; and a method for treating or preventing autoimmunity disease using the same.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: May 31, 2016
    Assignee: JANUS BIOTHERAPEUTICS, INC.
    Inventors: Grayson B. Lipford, Charles M. Zepp
  • NOVEL IMMUNE SYSTEM MODULATORS
    Publication number: 20160074403
    Abstract: The present invention relates to a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same; and a method for treating or preventing autoimmunity disease using the same.
    Type: Application
    Filed: September 4, 2015
    Publication date: March 17, 2016
    Inventors: Grayson B. LIPFORD, Charles M. ZEPP
  • Tolerogenic synthetic nanocarriers
    Patent number: 9265815
    Abstract: This invention relates, at least in part, to compositions comprising synthetic nanocarriers and immunosuppressants that result in immune suppressive effects. Such compositions can further comprise antigen and provide antigen-specific tolerogenic immune responses.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: February 23, 2016
    Assignee: Selecta Biosciences, Inc.
    Inventors: Christopher Fraser, Grayson B. Lipford, Christopher J. Roy, Roberto A. Maldonado
  • IMMUNOMODULATORY AGENT-POLYMERIC COMPOUNDS
    Publication number: 20150328300
    Abstract: This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.
    Type: Application
    Filed: March 13, 2015
    Publication date: November 19, 2015
    Applicant: Selecta Biosciences, Inc.
    Inventors: Charles Zepp, Grayson B. Lipford, Yun Gao, Lloyd Johnston, Fen-ni Fu, Mark J. Keegan, Sam Baldwin