Abstract: A biosensor (102) for determining the presence or amount of a substance in a sample and methods of use of the biosensor (102) are provided. The biosensor (102) for receiving a user sample to be analyzed includes a mixture for electrochemical reaction with an analyte. The mixture includes an enzyme, a mediator and an oxidizable species as an internal reference.

Abstract: An electrochemical sensor strip has a base and a first electrode and a second electrode on the base. An oxidoreductase enzyme and a mediator are on the first electrode, and a soluble redox species is on the second electrode. The soluble redox species may be an organotransition metal complex, a transition metal coordination complex, an electroactive organic molecule, or mixtures thereof.

Abstract: An electrochemical test sensor includes a lid and a base. The base has a length and a width. The length of the base is greater than the width of the base. The base includes at least a working electrode, a counter electrode and at least three test-sensor contacts for electrically connecting to a meter. The at least three test-sensor contacts are spaced along the length of the base from each other. The base and the lid assist in forming a fluid chamber for receiving the fluid sample. The electrochemical test sensor further includes a reagent to assist in determining the concentration of the analyte in the fluid sample.

Abstract: A sensor system, device, and methods for determining the concentration of an analyte in a sample is described. Gated amperometric pulse sequences including multiple duty cycles of sequential excitations and relaxations may provide a shorter analysis time and/or improve the accuracy and/or precision of the analysis. The disclosed gated amperometric pulse sequences may reduce analysis errors arising from the hematocrit effect, variance in cap-gap volumes, non-steady-state conditions, mediator background, under-fill, temperature changes in the sample, and a single set of calibration constants.

Abstract: A sensor system, device, and methods for determining the concentration of an analyte in a sample is described. Gated amperometric pulse sequences including multiple duty cycles of sequential excitations and relaxations may provide a shorter analysis time and/or improve the accuracy and/or precision of the analysis. The disclosed gated amperometric pulse sequences may reduce analysis errors arising from the hematocrit effect, variance in cap-gap volumes, non-steady-state conditions, mediator background, under-fill, temperature changes in the sample, and a single set of calibration constants.

Abstract: A method of forming an electrochemical test sensor includes providing a base. Electrochemically-active material is placed on the base. Dielectric material is applied over the electrochemically-active material. A first selected area of the dielectric material is laser-ablated to expose the electrochemically-active material. A second selected area of the dielectric material and the electrochemically-active material are laser-ablated to expose the base. The first selected area is different from the second selected area. A second layer is applied to assist in forming a channel in the test sensor. The channel assists in allowing a fluid sample to contact a reagent located therein. The dielectric material is located between the base and the second layer.

Abstract: A method of forming an electrochemical test sensor includes providing a base. Electrochemically-active material is placed on the base. Dielectric material is applied over the electrochemically-active material. A first selected area of the dielectric material is laser-ablated to expose the electrochemically-active material. A second selected area of the dielectric material and the electrochemically-active material are laser-ablated to expose the base. The first selected area is different from the second selected area. A second layer is applied to assist in forming a channel in the test sensor. The channel assists in allowing a fluid sample to contact a reagent located therein. The dielectric material is located between the base and the second layer.

Abstract: An electrochemical test sensor configured to determine an analyte concentration of a fluid sample comprises a base including a first end, a second opposing end, a first side and a second side bridging the first and second opposing ends. The test sensor further comprises a plurality of electrodes formed on the base at or near the first end. The plurality of electrodes includes a working electrode and a counter electrode. The sensor further comprises a first test-sensor contact formed on the base at or near the second opposing end and coupled to the working electrode by a first conductive lead. The sensor further comprises a second test-sensor contact formed on the base at or near the second opposing end and coupled to the counter electrode by a second conductive lead. The positions of the first and second test-sensor contacts correspond with calibration information assigned to the test sensor.

Abstract: An electrochemical sensor strip has a base and a first electrode and a second electrode on the base. An oxidoreductase enzyme and a mediator are on the first electrode, and a soluble redox species is on the second electrode. The soluble redox species may be an organotransition metal complex, a transition metal coordination complex, an electroactive organic molecule, or mixtures thereof.

Abstract: Testing of the performance of an electrochemical meter used to measure the presence of an analyte in a biological sample, particularly glucose in whole blood, includes introducing a control solution containing a predetermined amount of the analyte and a predetermined amount of an internal reference compound. The internal reference compound is selected such that it is oxidized at a potential greater than that used to oxidize the analyte, thereby making it possible to distinguish the control solution from a biological sample.

Abstract: An electrochemical sensor strip has a base and a first electrode and a second electrode on the base. An oxidoreductase enzyme and a mediator are on the first electrode, and a soluble redox species is on the second electrode. The soluble redox species may be an organotransition metal complex, a transition metal coordination complex, an electroactive organic molecule, or mixtures thereof.

Abstract: Testing of the performance of an electrochemical meter used to measure the presence of an analyte in a biological sample, particularly glucose in whole blood, includes introducing a control solution containing a predetermined amount of the analyte and a predetermined amount of an internal reference compound. The internal reference compound is selected such that it is oxidized at a potential greater than that used to oxidize the analyte, thereby making it possible to distinguish the control solution from a biological sample.

Abstract: A method of forming an electrochemical test sensor includes providing a base. Electrochemically-active material is placed on the base. Dielectric material is applied over the electrochemically-active material. A first selected area of the dielectric material is laser-ablated to expose the electrochemically-active material. A second selected area of the dielectric material and the electrochemically-active material are laser-ablated to expose the base. The first selected area is different from the second selected area. A second layer is applied to assist in forming a channel in the test sensor. The channel assists in allowing a fluid sample to contact a reagent located therein. The dielectric material is located between the base and the second layer.

Abstract: An electrochemical test sensor includes a lid and a base. The base has a length and a width. The length of the base is greater than the width of the base. The base includes at least a working electrode, a counter electrode and at least three test-sensor contacts for electrically connecting to a meter. The at least three test-sensor contacts are spaced along the length of the base from each other. The base and the lid assist in forming a fluid chamber for receiving the fluid sample. The electrochemical test sensor further includes a reagent to assist in determining the concentration of the analyte in the fluid sample.

Abstract: An electrochemical test sensor configured to determine an analyte concentration of a fluid sample comprises a base including a first end, a second opposing end, a first side and a second side bridging the first and second opposing ends. The test sensor further comprises a plurality of electrodes formed on the base at or near the first end. The plurality of electrodes includes a working electrode and a counter electrode. The sensor further comprises a first test-sensor contact formed on the base at or near the second opposing end and coupled to the working electrode by a first conductive lead. The sensor further comprises a second test-sensor contact formed on the base at or near the second opposing end and coupled to the counter electrode by a second conductive lead. The positions of the first and second test-sensor contacts correspond with calibration information assigned to the test sensor.

Abstract: Testing of the performance of an electrochemical meter used to measure the presence of an analyte in a biological sample, particularly glucose in whole blood, includes introducing a control solution containing a predetermined amount of the analyte and a predetermined amount of an internal reference compound. The internal reference compound is selected such that it is oxidized at a potential greater than that used to oxidize the analyte, thereby making it possible to distinguish the control solution from a biological sample.

Abstract: A sensor system, device, and methods for determining the concentration of an analyte in a sample is described. Gated amperometric pulse sequences including multiple duty cycles of sequential excitations and relaxations may provide a shorter analysis time and/or improve the accuracy and/or precision of the analysis. The disclosed gated amperometric pulse sequences may reduce analysis errors arising from the hematocrit effect, variance in cap-gap volumes, non-steady-state conditions, mediator background, under-fill, temperature changes in the sample, and a single set of calibration constants.