Patents by Inventor Gregory A. Lazar

Gregory A. Lazar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Optimized Fc Variants
    Publication number: 20120258092
    Abstract: The present invention relates to optimized CD20 antibodies having Fc variants, methods for their generation, and method for their application, such as methods of enhancing macrophage activation, particularly for therapeutic purposes.
    Type: Application
    Filed: December 23, 2011
    Publication date: October 11, 2012
    Applicant: Xencor, Inc.
    Inventors: Bassil I. Dahiyat, Gregory A. Lazar, Omid Vafa
  • NOVEL IMMUNOGLOBULIN INSERTIONS, DELETIONS, AND SUBSTITUTIONS
    Publication number: 20120225058
    Abstract: An Fc variant of a parent Fc polypeptide, wherein said Fc variant exhibits altered binding to one or more Fc?Rs, wherein said Fc variant comprises at least one amino acid insertion in the Fc region of said parent Fc polypeptide.
    Type: Application
    Filed: December 23, 2011
    Publication date: September 6, 2012
    Applicant: Xencor, Inc.
    Inventors: Gregory A. Lazar, Bassil I. Dahiyat, Wei Dang, Sher Bahadur Karki, Omid Vafa
  • Fc VARIANTS THAT EXTEND ANTIBODY HALF-LIFE
    Publication number: 20120128663
    Abstract: The invention relates generally to compositions and methods for altering the serum half-life in vivo of an antibody.
    Type: Application
    Filed: October 12, 2011
    Publication date: May 24, 2012
    Applicant: Xencor, Inc.
    Inventor: Gregory A. Lazar
  • ANTIBODIES WITH MODIFIED ISOELECTRIC POINTS
    Publication number: 20120028304
    Abstract: The invention relates generally to compositions and methods for altering the isoelectric point of an antibody, and in some cases, resulting in improved plasma pharmacokinetics, e.g. increased serum half-life in vivo.
    Type: Application
    Filed: July 29, 2011
    Publication date: February 2, 2012
    Applicant: XENCOR, INC.
    Inventors: Bassil I. Dahiyat, Gregory A. Lazar, Matthew J. Bernett
  • Immunoglobulin insertions, deletions and substitutions
    Patent number: 8101720
    Abstract: An Fc variant of a parent Fc polypeptide, wherein said Fc variant exhibits altered binding to one or more Fc?Rs, wherein said Fc variant comprises at least one amino acid insertion in the Fc region of said parent Fc polypeptide.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: January 24, 2012
    Assignee: Xencor, Inc.
    Inventors: Gregory A. Lazar, Bassil I. Dahiyat, Wei Dang, Sher Bahadur Karki, Omid Vafa
  • NOVEL CTLA4-IG IMMUNOADHESINS
    Publication number: 20110287032
    Abstract: The present application relates to CTLA4-Ig immunoadhesins that target CD80 and CD86, and their use, particularly for therapeutic purposes.
    Type: Application
    Filed: February 22, 2011
    Publication date: November 24, 2011
    Applicant: XENCOR, INC.
    Inventors: Gregory A. Lazar, Matthew J. Bernett
  • ANTIBODY VARIANTS WITH ENHANCED COMPLEMENT ACTIVITY
    Publication number: 20110236375
    Abstract: The present invention relates to novel Fc variants that comprise at least one novel amino acid residue which may provide for enhanced effector function. More specifically, this invention provides Fc variants that have modified binding affinity to one or more Fc receptor or ligand (e.g., Fc gamma R, C1q). Additionally, the Fc variants have altered complement dependent cytotoxicity (CDC) activity and/or antibody-dependent cell-mediated cytotoxicity (ADCC). The invention further provides methods and protocols for the application of said Fc variants, particularly for therapeutic purposes.
    Type: Application
    Filed: January 19, 2011
    Publication date: September 29, 2011
    Applicant: XENCOR, INC.
    Inventors: Gregory A. Lazar, Sher Bahadur Karki, Gregory L. Moore
  • COMPOSITIONS AND METHODS FOR SIMULTANEOUS BIVALENT AND MONOVALENT CO-ENGAGEMENT OF ANTIGENS
    Publication number: 20110054151
    Abstract: Immunoglobulin compositions that simultaneously co-engage antigens, where one of the antigens is bound bivalently and the other antigen is bound monovalently. The novel immunoglobulins described preferably utilize heterodimeric Fc regions.
    Type: Application
    Filed: September 2, 2010
    Publication date: March 3, 2011
    Applicant: Xencor, Inc.
    Inventors: Gregory A. Lazar, Gregory L. Moore
  • Optimized Fc variants
    Publication number: 20090053211
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: May 5, 2005
    Publication date: February 26, 2009
    Applicant: Xencor, Inc.
    Inventors: Gregory Lazar, Wei Dang, John Desjarlais, Sher Karki, Omid Vafa, Robert Hayes, Jost Vielmetter
  • OPTIMIZED IGF-1R ANTIBODIES AND METHODS OF USING THE SAME
    Publication number: 20080152649
    Abstract: The present invention describes antibodies that target IGF-1R, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification improves the sequence of said antibody and/or alters the effector function of said antibody. Also disclosed are methods of using the antibodies of the invention.
    Type: Application
    Filed: February 7, 2008
    Publication date: June 26, 2008
    Applicant: Xencor, Inc.
    Inventors: Aaron K. Chamberlain, Wei Dang, Gregory A. Lazar
  • Fc Variants with Increased Affinity for FcyRIIC
    Publication number: 20080057056
    Abstract: The present invention relates to Fc variants having increased affinity for Fc?RIIc, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: August 20, 2007
    Publication date: March 6, 2008
    Applicant: Xencor, Inc.
    Inventors: Gregory Lazar, Wei Dang, John Desjarlais, Sher Karki, Omid Vafa, Robert Hayes
  • Fc Variants with Increased Affinity for FcyRIIc
    Publication number: 20080051563
    Abstract: The present invention relates to Fc variants having increased affinity for Fc?RIIc, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: August 20, 2007
    Publication date: February 28, 2008
    Applicant: Xencor, Inc.
    Inventors: Gregory Lazar, Wei Dang, John Desjarlais, Sher Karki, Omid Vafa, Robert Hayes
  • Fc Variants Having Decreased Affinity for FcyRl
    Publication number: 20070286859
    Abstract: The present invention relates to Fc variants having decreased affinity for Fc?RI, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: June 21, 2007
    Publication date: December 13, 2007
    Applicant: Xencor, Inc.
    Inventors: Gregory Lazar, Wei Dang, John Desjarlais, Sher Karki, Omid Vafa, Robert Hayes
  • Fc Variants With Optimized Fc Receptor Binding Properties
    Publication number: 20070275460
    Abstract: The present invention relates to Fc variants with optimized Fc receptor binding properties, methods for their generation, Fc polypeptides comprising Fc variants with optimized Fc receptor binding properties, and methods for using Fc variants with optimized Fc receptor binding properties.
    Type: Application
    Filed: October 3, 2006
    Publication date: November 29, 2007
    Applicant: Xencor.Inc.
    Inventors: John Desjarlais, Sher Karki, Gregory Lazar, John Richards, Gregory Moore, David Carmichael
  • Fc Variants with Increased Affinity for FcyRlla
    Publication number: 20070248603
    Abstract: The present invention relates to Fc variants having increased affinity for Fc?RIIa, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: June 21, 2007
    Publication date: October 25, 2007
    Applicant: Xencor, Inc.
    Inventors: Gregory Lazar, Wei Dang, John Desjarlais, Sher Karki, Omid Vafa, Robert Hayes
  • Fc Variants Having Increased Affinity for FcyRllc
    Publication number: 20070248602
    Abstract: The present invention relates to Fc variants having increased affinity for Fc?RIIc, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: June 19, 2007
    Publication date: October 25, 2007
    Applicant: Xencor, Inc.
    Inventors: Gregory Lazar, Wei Dang, John Desjarlais, Sher Karki, Omid Vafa, Robert Hayes
  • Fc Variants Having Decreased Affinity for FcyRlla
    Publication number: 20070243188
    Abstract: The present invention relates to Fc variants having decreased affinity for Fc?RIIa, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: June 21, 2007
    Publication date: October 18, 2007
    Applicant: Xencor, Inc.
    Inventors: Gregory Lazar, Wei Dang, John Desjarlais, Sher Karki, Omid Vafa, Robert Hayes
  • Fc Variants Having Decreased Affinity for FcyRllla
    Publication number: 20070237767
    Abstract: The present invention relates to Fc variants having decreased affinity for Fc?RIIIa, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: June 21, 2007
    Publication date: October 11, 2007
    Applicant: Xencor, Inc.
    Inventors: Gregory Lazar, Wei Dang, John Desjarlais, Sher Karki, Omid Vafa, Robert Hayes
  • Fc Variants Having Increased Affinity for FcyRl
    Publication number: 20070237765
    Abstract: The present invention relates to Fc variants having Increased affinity for Fc?RI, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: June 19, 2007
    Publication date: October 11, 2007
    Applicant: Xencor, Inc.
    Inventors: Gregory Lazar, Wei Dang, John Desjarlais, Sher Karki, Omid Vafa, Robert Hayes
  • Fc Variants Having Decreased Affinity for FcyRIIc
    Publication number: 20070238665
    Abstract: The present invention relates to Fc variants having decreased affinity for Fc?RIIc, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: June 19, 2007
    Publication date: October 11, 2007
    Applicant: Xencor, Inc.
    Inventors: Gregory Lazar, Wei Dang, John Desjarlais, Sher Karki, Omid Vafa, Robert Hayes