Patents by Inventor Gregory Allen Penner
Gregory Allen Penner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11859187Abstract: An aptamer composition is disclosed which has one or more oligonucleotides that include at least one of deoxyribonucleotides, ribonucleotides, derivatives of deoxyribonucleotides, derivatives of ribonucleotides, or mixtures thereof. The aptamer composition has a binding affinity for one or more cellular membrane glycoproteins selected from the group consisting of: intercellular adhesion molecule 1 (ICAM-1), low-density lipoprotein receptor (LDLR) family members, and cadherin-related family member 3 (CDHR3), preferably intercellular adhesion molecule 1 (ICAM-1), and is configured to reduce the binding of one or more human rhinoviruses to the intercellular adhesion molecule 1 (ICAM-1).Type: GrantFiled: June 24, 2021Date of Patent: January 2, 2024Assignee: The Procter & Gamble CompanyInventors: Juan Esteban Velasquez, Spencer Christopher Rupard, Amy Violet Trejo, Adam Michael Pitz, Kelly Lee Schmeichel, Erin Nicole Swigart, Gregory Allen Penner
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Patent number: 11806419Abstract: Nucleic acid aptamers having a high binding affinity and specificity for malodorous molecules and the use of such aptamers to reduce the intensity of the undesirable smells in personal care compositions.Type: GrantFiled: April 16, 2020Date of Patent: November 7, 2023Assignee: The Procter & Gamble CompanyInventors: Juan Esteban Velasquez, Amy Violet Trejo, Gregory Allen Penner, Stevan David Jones
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Publication number: 20230340495Abstract: An aptamer composition is disclosed which has one or more oligonucleotides that include at least one of deoxyribonucleotides, ribonucleotides, derivatives of deoxyribonucleotides, derivatives of ribonucleotides, or mixtures thereof. The aptamer composition has a binding affinity for one or more cellular membrane glycoproteins selected from the group consisting of: intercellular adhesion molecule 1 (ICAM-1), low-density lipoprotein receptor (LDLR) family members, and cadherin-related family member 3 (CDHR3), preferably intercellular adhesion molecule 1 (ICAM-1), and is configured to reduce the binding of one or more human rhinoviruses to the intercellular adhesion molecule 1 (ICAM-1).Type: ApplicationFiled: December 14, 2022Publication date: October 26, 2023Inventors: Juan Esteban VELASQUEZ, Spencer Christopher RUPARD, Amy Violet TREJO, Adam Michael PITZ, Kelly Lee SCHMEICHEL, Erin Nicole SWIGART, Gregory Allen PENNER, HILDA ANDAMICHE NAMANJA-MAGLIANO, Matthew Scott Wagner
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Publication number: 20230313201Abstract: An aptamer composition is disclosed which has one or more oligonucleotides that include at least one of deoxyribonucleotides, ribonucleotides, derivatives of deoxyribonucleotides, derivatives of ribonucleotides, or mixtures thereof. The aptamer composition has a binding affinity for one or more cellular membrane glycoproteins selected from the group consisting of: intercellular adhesion molecule 1 (ICAM-1), low-density lipoprotein receptor (LDLR) family members, and cadherin-related family member 3 (CDHR3), preferably intercellular adhesion molecule 1 (ICAM-1), and is configured to reduce the binding of one or more human rhinoviruses to the intercellular adhesion molecule 1 (ICAM-1).Type: ApplicationFiled: December 14, 2022Publication date: October 5, 2023Inventors: Juan Esteban VELASQUEZ, Spencer Christopher RUPARD, Amy Violet TREJO, Adam Michael PITZ, Kelly Lee SCHMEICHEL, Erin Nicole SWIGART, Gregory Allen PENNER, HILDA ANDAMICHE NAMANJA-MAGLIANO, Matthew Scott Wagner
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Publication number: 20230287433Abstract: An aptamer composition is disclosed which has one or more oligonucleotides that include at least one of deoxyribonucleotides, ribonucleotides, derivatives of deoxyribonucleotides, derivatives of ribonucleotides, or mixtures thereof. The aptamer composition has a binding affinity for one or more cellular membrane glycoproteins selected from the group consisting of: intercellular adhesion molecule 1 (ICAM-1), low-density lipoprotein receptor (LDLR) family members, and cadherin-related family member 3 (CDHR3), preferably intercellular adhesion molecule 1 (ICAM-1), and is configured to reduce the binding of one or more human rhinoviruses to the intercellular adhesion molecule 1 (ICAM-1).Type: ApplicationFiled: December 14, 2022Publication date: September 14, 2023Inventors: Juan Esteban VELASQUEZ, Spencer Christopher RUPARD, Amy Violet TREJO, Adam Michael PITZ, Kelly Lee SCHMEICHEL, Erin Nicole SWIGART, Gregory Allen PENNER, HILDA ANDAMICHE NAMANJA-MAGLIANO, Matthew Scott Wagner
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Publication number: 20230287434Abstract: An aptamer composition is disclosed which has one or more oligonucleotides that include at least one of deoxyribonucleotides, ribonucleotides, derivatives of deoxyribonucleotides, derivatives of ribonucleotides, or mixtures thereof. The aptamer composition has a binding affinity for one or more cellular membrane glycoproteins selected from the group consisting of: intercellular adhesion molecule 1 (ICAM-1), low-density lipoprotein receptor (LDLR) family members, and cadherin-related family member 3 (CDHR3), preferably intercellular adhesion molecule 1 (ICAM-1), and is configured to reduce the binding of one or more human rhinoviruses to the intercellular adhesion molecule 1 (ICAM-1).Type: ApplicationFiled: December 14, 2022Publication date: September 14, 2023Inventors: Juan Esteban VELASQUEZ, Spencer Christopher RUPARD, Amy Violet TREJO, Adam Michael PITZ, Kelly Lee SCHMEICHEL, Erin Nicole SWIGART, Gregory Allen PENNER, HILDA ANDAMICHE NAMANJA-MAGLIANO, Matthew Scott Wagner
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Patent number: 11505799Abstract: Provided herein are aptamers for binding lipoproteins, systems for binding lipoproteins, and methods of detecting lipoproteins in a sample. The aptamers are useful for detecting the levels of lipoproteins in a biological sample and selectively detecting LDL particles in the presence of HDL particles. The aptamers can also be used as therapeutic agents against various diseases.Type: GrantFiled: July 6, 2018Date of Patent: November 22, 2022Assignee: InnaMed, Inc.Inventors: Eshwar Inapuri, Anup Singh, Gregory Allen Penner
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Patent number: 11384357Abstract: The present invention is directed to an aptamer composition comprising at least one oligonucleotide consisting of: deoxyribonucleotides, ribonucleotides, derivatives of deoxyribonucleotides, derivatives of ribonucleotides, and mixtures thereof; wherein said aptamer composition has a binding affinity for one or more fungi species from the genus Malassezia.Type: GrantFiled: February 8, 2019Date of Patent: July 12, 2022Assignee: The Procter and Gamble CompanyInventors: Juan Esteban Velasquez, Amy Violet Trejo, Laurie Ellen Breyfogle, James Patrick Henry, Douglas Joseph Dobrozsi, Gregory Allen Penner
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Publication number: 20210403919Abstract: An aptamer composition is disclosed which has one or more oligonucleotides that include at least one of deoxyribonucleotides, ribonucleotides, derivatives of deoxyribonucleotides, derivatives of ribonucleotides, or mixtures thereof. The aptamer composition has a binding affinity for one or more cellular membrane glycoproteins selected from the group consisting of: intercellular adhesion molecule 1 (ICAM-1), low-density lipoprotein receptor (LDLR) family members, and cadherin-related family member 3 (CDHR3), preferably intercellular adhesion molecule 1 (ICAM-1), and is configured to reduce the binding of one or more human rhinoviruses to the intercellular adhesion molecule 1 (ICAM-1).Type: ApplicationFiled: June 24, 2021Publication date: December 30, 2021Inventors: Juan Esteban Velasquez, Spencer Christopher Rupard, Amy Violet Trejo, Adam Michael Pitz, Kelly Lee Schmeichel, Erin Nicole Swigart, Gregory Allen Penner
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Publication number: 20200330353Abstract: Nucleic acid aptamers having a high binding affinity and specificity for malodorous molecules and the use of such aptamers to reduce the intensity of the undesirable smells in personal care compositions.Type: ApplicationFiled: April 16, 2020Publication date: October 22, 2020Inventors: Juan Esteban Velasquez, Amy Violet Trejo, Gregory Allen Penner, Stevan David Jones
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Patent number: 10676748Abstract: Consumer product compositions comprise a surfactant and a nucleic acid aptamer. The nucleic acid aptamer comprises at least one oligonucleotide comprising: deoxyribonucleotides, ribonucleotides, derivatives of deoxyribonucleotides, derivatives of ribonucleotides, or mixtures thereof. The nucleic acid aptamer has a binding affinity for an epitope of a surface being treated with the consumer product composition.Type: GrantFiled: August 9, 2018Date of Patent: June 9, 2020Assignee: The Procter & Gamble CompanyInventors: Juan Esteban Velasquez, Amy Violet Trejo, Paul Albert Sagel, Gregory Allen Penner
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Publication number: 20200131515Abstract: Provided herein are aptamers for binding lipoproteins, systems for binding lipoproteins, and methods of detecting lipoproteins in a sample. The aptamers are useful for detecting the levels of lipoproteins in a biological sample and selectively detecting LDL particles in the presence of HDL particles. The aptamers can also be used as therapeutic agents against various diseases.Type: ApplicationFiled: July 6, 2018Publication date: April 30, 2020Inventors: Eshwar INAPURI, Anup SINGH, Gregory Allen PENNER
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Publication number: 20200002703Abstract: The present invention is directed to an aptamer composition comprising at least one oligonucleotide consisting of: deoxyribonucleotides, ribonucleotides, derivatives of deoxyribonucleotides, derivatives of ribonucleotides, and mixtures thereof; wherein said aptamer composition has a binding affinity for one or more fungi species from the genus Malassezia.Type: ApplicationFiled: February 8, 2019Publication date: January 2, 2020Inventors: Juan Esteban Velasquez, Amy Violet Trejo, Laurie Ellen Breyfogle, James Patrick Henry, Douglas Joseph Dobrozsi, Gregory Allen Penner
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Publication number: 20200000697Abstract: The present invention is directed to an aptamer composition comprising at least one oligonucleotide consisting of: deoxyribonucleotides, ribonucleotides, derivatives of deoxyribonucleotides, derivatives of ribonucleotides, and mixtures thereof; wherein said aptamer composition has a binding affinity for a material selected from the group consisting of: undamaged hair, damaged hair, hair cuticle, hair epicuticle, hair exocuticle, hair endocuticle, hair cortex, hair keratins, hair F-layer, hair lipids, 18-methyleicosanoic acid, and mixtures thereof.Type: ApplicationFiled: February 8, 2019Publication date: January 2, 2020Inventors: Juan Esteban Velasquez, Amy Violet Trejo, Jennifer Mary Marsh, Gregory Allen Penner
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Publication number: 20190048349Abstract: An aptamer composition is disclosed which has one or more oligonucleotides that include at least one of deoxyribonucleotides, ribonucleotides, derivatives of deoxyribonucleotides, derivatives of ribonucleotides, or mixtures thereof. The aptamer composition has a binding affinity for a material that is at least one of tooth, enamel, dentin, carbonated calcium-deficient hydroxyapatite, or mixtures thereof.Type: ApplicationFiled: August 9, 2018Publication date: February 14, 2019Inventors: Juan Esteban Velasquez, Amy Violet Trejo, Paul Albert Sagel, Gregory Allen Penner
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Publication number: 20190048348Abstract: Consumer product compositions comprise a surfactant and a nucleic acid aptamer. The nucleic acid aptamer comprises at least one oligonucleotide comprising: deoxyribonucleotides, ribonucleotides, derivatives of deoxyribonucleotides, derivatives of ribonucleotides, or mixtures thereof. The nucleic acid aptamer has a binding affinity for an epitope of a surface being treated with the consumer product composition.Type: ApplicationFiled: August 9, 2018Publication date: February 14, 2019Inventors: Juan Esteban Velasquez, Amy Violet Trejo, Paul Albert Sagel, Gregory Allen Penner
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Publication number: 20120225494Abstract: The present invention relates to DNA ligands capable of binding to aflatoxin and zearalenone. The invention relates also to methods for determining the presence and concentration of aflatoxin and zearalenone in samples such as agricultural and food products, and to methods for removing or reducing the level of aflatoxin and zearalenone in samples such as agricultural and food products. The invention further relates to methods for identifying DNA ligands capable of binding to aflatoxin and zearalenone. The invention further relates to new DNA sequences.Type: ApplicationFiled: August 20, 2010Publication date: September 6, 2012Inventors: Linda Chryseis Le, Jorge Andres Cruz-Aguado, Gregory Allen Penner
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Publication number: 20120190015Abstract: The present invention relates to methods and an apparatus for determining the presence and concentration of an analyte in a sample and the binding of the analyte to a nucleic acid ligand that include measuring the fluorescence emitted by a rare earth element, i.e., terbium, in the presence of the analyte and the nucleic acid ligand. Specific embodiments include the use of terbium and nucleic acid ligands that specifically bind the mycotoxin ochratoxin. A, to detect and quantify ochratoxin A in, for example, food samples such as grain, wine, or beer. The detection of thrombin using terbium and a thrombin-specific nucleic acid ligand is also disclosed. The present invention also relates to a composition comprising a rare earth element as a cation that facilitates the binding of an analyte to a nucleic acid ligand of the analyte.Type: ApplicationFiled: July 23, 2010Publication date: July 26, 2012Inventors: Jorge Andres Cruz-Aguado, Gregory Allen Penner
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Publication number: 20110306508Abstract: The presence of mycotoxins in agricultural products necessitates large scale testing of a wide range of sample material to ensure the safety of food and feed. The mycotoxin ochratoxin A represents an enablement for all mycotoxins as the level of sensitivity necessary for regulatory requirements for this compound at the part per billion level are as low or lower than any other mycotoxin. This invention describes the identification of a set of DNA ligands with sufficiently high binding affinity and specificity for ochratoxin A to enable an improvement over existing methods for the separation, concentration and quantitative determination of ochratoxin A in sample material.Type: ApplicationFiled: January 9, 2009Publication date: December 15, 2011Inventors: Gregory Allen Penner, Jorge Andres Cruz-Aguado