Patents by Inventor Gregory Biesecker

Gregory Biesecker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High Affinity Nucleic Acid Ligands of Complement System Proteins
    Publication number: 20110196021
    Abstract: Methods are described for the identification and preparation of high-affinity Nucleic Acid Ligands to Complement System Proteins. Methods are described for the identification and preparation of high affinity Nucleic Acid Ligands to Complement System Proteins C1q, C3 and C5. Included in the invention are specific RNA ligands to C1q, C3 and C5 identified by the SELEX method.
    Type: Application
    Filed: January 19, 2011
    Publication date: August 11, 2011
    Applicant: GILEAD SCIENCES, INC.
    Inventors: Gregory Biesecker, Larry Gold
  • High affinity nucleic acid ligands of complement system proteins
    Patent number: 7964572
    Abstract: Methods are described for the identification and preparation of high-affinity Nucleic Acid Ligands to Complement System Proteins. Methods are described for the identification and preparation of high affinity Nucleic Acid Ligands to Complement System Proteins C1q, C3 and C5. Included in the invention are specific RNA ligands to C1q, C3 and C5 identified by the SELEX method.
    Type: Grant
    Filed: November 28, 2005
    Date of Patent: June 21, 2011
    Assignee: Gilead Sciences, Inc.
    Inventors: Gregory Biesecker, Larry Gold
  • Systematic evolution of ligands by exponential enrichment: blended SELEX
    Patent number: 7176295
    Abstract: A method is described for generating blended nucleic acid ligands containing non-nucleic acid functional units. Specifically, a SELEX identified RNA ligand to the integrin gpIIbIIIa is conjugated to the peptide Gly-Arg-Gly-Asp-Thr-Pro (SEQ ID NO:1). This blended RNA ligand inhibits the biological activity of gpIIbIIIa with high specificity. Also described is a single-stranded DNA ligand to elastase coupled to N-methoxysuccinyl-Ala-Ala-Pro-Val-chloromethyl ketone (SEQ ID NO:2). This elastase blended nucleic acid ligand inhibits the biological activity of elastase.
    Type: Grant
    Filed: October 2, 2002
    Date of Patent: February 13, 2007
    Assignee: Gilead Sciences, Inc.
    Inventors: Gregory Biesecker, Sumeda Jayasena, Larry Gold, Drew Smith, Gary P. Kirschenheuter
  • High affinity nucleic acid ligands of complement system proteins
    Publication number: 20060079477
    Abstract: Methods are described for the identification and preparation of high-affinity Nucleic Acid Ligands to Complement System Proteins. Methods are described for the identification and preparation of high affinity Nucleic Acid Ligands to Complement System Proteins C1q, C3 and C5. Included in the invention are specific RNA ligands to C1q, C3 and C5 identified by the SELEX method.
    Type: Application
    Filed: November 28, 2005
    Publication date: April 13, 2006
    Applicant: GILEAD SCIENCES, INC.
    Inventors: Gregory Biesecker, Larry Gold
  • High affinity nucleic acid ligands of complement system proteins
    Publication number: 20030191084
    Abstract: Methods are described for the identification and preparation of high-affinity Nucleic Acid Ligands to Complement System Proteins. Methods are described for the identification and preparation of high affinity Nucleic Acid Ligands to Complement System Proteins C1q, C3 and C5. Included in the invention are specific RNA ligands to C1q, C3 and C5 identified by the SELEX method.
    Type: Application
    Filed: May 8, 2003
    Publication date: October 9, 2003
    Applicant: GILEAD SCIENCES, INC.
    Inventors: Gregory Biesecker, Larry Gold
  • High affinity nucleic acid ligands of complement system proteins
    Patent number: 6566343
    Abstract: Methods are described for the identification and preparation of high-affinity Nucleic Acid Ligands to Complement System Proteins. Methods are described for the identification and preparation of high affinity Nucleic Acid Ligands to Complement System Proteins C1q, C3 and C5. Included in the invention are specific RNA ligands to C1q, C3 and C5 identified by the SELEX method.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: May 20, 2003
    Assignee: Gilead Sciences, Inc.
    Inventors: Gregory Biesecker, Larry Gold
  • High affinity nucleic acid ligands of complement system proteins
    Publication number: 20030078221
    Abstract: Methods are described for the identification and preparation of high-affinity Nucleic Acid Ligands to Complement System Proteins. Methods are described for the identification and preparation of high affinity Nucleic Acid Ligands to Complement System Proteins C1q, C3 and C5. Included in the invention are specific RNA ligands to C1q, C3 and C5 identified by the SELEX method.
    Type: Application
    Filed: January 3, 2002
    Publication date: April 24, 2003
    Applicant: Gilead Sciences, Inc.
    Inventors: Gregory Biesecker, Larry Gold
  • High affinity nucleic acid ligands of complement system proteins
    Patent number: 6395888
    Abstract: Methods are described for the identification and preparation of high-affinity Nucleic Acid Ligands to Complement System Proteins. Methods are described for the identification and preparation of high affinity Nucleic Acid Ligands to Complement System Proteins C1q, C3 and C5. Included in the invention are specific RNA ligands to C1q, C3 and C5 identified by the SELEX method.
    Type: Grant
    Filed: September 29, 1998
    Date of Patent: May 28, 2002
    Assignee: Gilead Sciences, Inc.
    Inventors: Gregory Biesecker, Larry Gold
  • High affinity nucleic acid ligands of complement system proteins
    Patent number: 6140490
    Abstract: Methods are described for the identification and preparation of high-affinity Nucleic Acid Ligands to Complement System Proteins. Methods are described for the identification and preparation of high affinity Nucleic Acid Ligands to Complement System Proteins C1q, C3 and C5. Included in the invention arc specific RNA ligands to C1q, C3 and C5 identified by the SELEX method.
    Type: Grant
    Filed: February 12, 1998
    Date of Patent: October 31, 2000
    Assignee: NeXstar Pharmaceuticals, Inc.
    Inventors: Gregory Biesecker, Larry Gold