Patents by Inventor Gregory C. Loney
Gregory C. Loney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220186208Abstract: Disclosed herein are methods and devices for preparing a sample of nucleic acid molecules from a biological sample. The methods and devices may perform similarly to or better than standard sample preparation methods. The nucleic acid molecules prepared using the methods and devices provided herein may be utilized for downstream applications, including polymerase chain reaction (PCR).Type: ApplicationFiled: October 22, 2021Publication date: June 16, 2022Inventors: David D. SWENSON, Gregory C. LONEY, Valeria REVILLA, Adrienne C. LAM, Helen HUANG, Colin KELLY, Victor BRIONES, Brian CIOPYK, Boris ANDREYEV, Adam DE LA ZERDA, Keith MORAVICK, Jesus CHING, Jennifer ALBRECHT, Ryan CENA, Edward BIBA, Jonathan HONG
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Patent number: 11193119Abstract: Disclosed herein are methods and devices for preparing a sample of nucleic acid molecules from a biological sample. The methods and devices may perform similarly to or better than standard sample preparation methods. The nucleic acid molecules prepared using the methods and devices provided herein may be utilized for downstream applications, including polymerase chain reaction (PCR).Type: GrantFiled: November 9, 2018Date of Patent: December 7, 2021Assignee: Visby Medical, Inc.Inventors: David D. Swenson, Gregory C. Loney, Valeria Revilla, Adrienne C. Lam, Helen Huang, Colin Kelly, Victor Briones, Brian Ciopyk, Boris Andreyev, Adam De La Zerda, Keith Moravick, Jesus Ching, Jennifer Albrecht, Ryan Cena, Edward Biba, Jonathan Hong
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Patent number: 10960399Abstract: Cartridge-based thermocyclers can include cartridges that are configured to move a fluid between distinct chambers. In some cases, the cartridge-based thermocyclers can be used for thermocycling a sample fluid comprising a deoxyribonucleic acid (DNA) target to perform polymerase chain reaction (PCR). Individual chambers can be heated, cooled, and/or compressed to mix fluid within the chamber or to propel fluid in the chamber into another chamber. The cartridges can have a laminate construction. The cartridges can be configured to enable multiplexed thermocycling and/or detection.Type: GrantFiled: December 20, 2018Date of Patent: March 30, 2021Assignee: Visby Medical, Inc.Inventors: Hamilton R. Tang, Adam De La Zerda, Kenneth I. Li, Kevin M. Limtao, Alan D. Baldwin, Gregory C. Loney
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Publication number: 20210069718Abstract: Cartridge-based thermocyclers can include cartridges that are configured to move a fluid between distinct chambers. In some cases, the cartridge-based thermocyclers can be used for thermocycling a sample fluid comprising a deoxyribonucleic acid (DNA) target to perform polymerase chain reaction (PCR). Individual chambers can be heated, cooled, and/or compressed to mix fluid within the chamber or to propel fluid in the chamber into another chamber. The cartridges can have a laminate construction. The cartridges can be configured to enable multiplexed thermocycling and/or detection.Type: ApplicationFiled: October 30, 2020Publication date: March 11, 2021Applicant: Visby Medical, Inc.Inventors: Hamilton R. TANG, Adam DE LA ZERDA, Kenneth I. LI, Kevin M. LIMTAO, Alan D. BALDWIN, Gregory C. LONEY
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Publication number: 20200406257Abstract: A method includes conveying a detection solution containing a target amplicon into a detection module of a molecular diagnostic test device. The detection module includes a detection surface including a series of capture probes to which a first portion of the target amplicon is bound when the detection solution is conveyed. A first reagent formulated to produce a visible signal indicating a presence of the target amplicon is then conveyed into the detection module. The first reagent is bound to a second portion of the target amplicon when the first reagent is conveyed. A second reagent is conveyed into the detection module. The second reagent includes a precipitating substrate formulated to catalyze the production of the visible signal by producing an insoluble colored product when the second reagent is in contact with the first reagent. The method includes viewing the visible signal via a transparent portion of the detection module.Type: ApplicationFiled: September 16, 2020Publication date: December 31, 2020Applicant: Visby Medical, Inc.Inventors: Boris ANDREYEV, Rajinder K. BHATIA, Victor BRIONES, Phoebe CAO, Jesus CHING, Brian CIOPYK, Adam DE LA ZERDA, Jonathan H. HONG, Helen HUANG, Colin KELLY, Adrienne C. LAM, Gregory C. LONEY, Danielle MCSHEERY, Keith E. MORAVICK, Valeria REVILLA, Shaunak ROY, David D. SWENSON
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Publication number: 20200086324Abstract: Disclosed herein are methods and devices for preparing a sample of nucleic acid molecules from a biological sample. The methods and devices may perform similarly to or better than standard sample preparation methods. The nucleic acid molecules prepared using the methods and devices provided herein may be utilized for downstream applications, including polymerase chain reaction (PCR).Type: ApplicationFiled: December 27, 2018Publication date: March 19, 2020Inventors: David D. Swenson, Adam De La Zerda, Gregory C. Loney, Valeria Revilla, Victor Briones, Boris Andreyev, Adrienne C. Lam, Brian Ciopyk, Helen Huang, Keith Moravick, Colin Kelly, Jesus Ching, Jennifer Albrecht, Ryan Cena, Edward Biba, Jonathan Hong
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Publication number: 20190232293Abstract: Cartridge-based thermocyclers can include cartridges that are configured to move a fluid between distinct chambers. In some cases, the cartridge-based thermocyclers can be used for thermocycling a sample fluid comprising a deoxyribonucleic acid (DNA) target to perform polymerase chain reaction (PCR). Individual chambers can be heated, cooled, and/or compressed to mix fluid within the chamber or to propel fluid in the chamber into another chamber. The cartridges can have a laminate construction. The cartridges can be configured to enable multiplexed thermocycling and/or detection.Type: ApplicationFiled: December 20, 2018Publication date: August 1, 2019Inventors: Hamilton R. TANG, Adam DE LA ZERDA, Kenneth I. LI, Kevin M. LIMTAO, Alan D. BALDWIN, Gregory C. LONEY
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Publication number: 20190136226Abstract: Disclosed herein are methods and devices for preparing a sample of nucleic acid molecules from a biological sample. The methods and devices may perform similarly to or better than standard sample preparation methods. The nucleic acid molecules prepared using the methods and devices provided herein may be utilized for downstream applications, including polymerase chain reaction (PCR).Type: ApplicationFiled: November 9, 2018Publication date: May 9, 2019Inventors: David D. SWENSON, Gregory C. LONEY, Valeria REVILLA, Adrienne C. LAM, Helen HUANG, Colin KELLY, Victor BRIONES, Brian CIOPYK, Boris ANDREYEV, Adam DE LA ZERDA, Keith MORAVICK, Jesus CHING, Jennifer ALBRECHT, Ryan CENA, Edward BIBA, Jonathan HONG
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Patent number: 10195610Abstract: Cartridge-based thermocyclers can include cartridges that are configured to move a fluid between distinct chambers. In some cases, the cartridge-based thermocyclers can be used for thermocycling a sample fluid comprising a deoxyribonucleic acid (DNA) target to perform polymerase chain reaction (PCR). Individual chambers can be heated, cooled, and/or compressed to mix fluid within the chamber or to propel fluid in the chamber into another chamber. The cartridges can have a laminate construction. The cartridges can be configured to enable multiplexed thermocycling and/or detection.Type: GrantFiled: March 9, 2015Date of Patent: February 5, 2019Assignee: Click Diagnostics, Inc.Inventors: Hamilton R. Tang, Adam De La Zerda, Kenneth I. Li, Kevin M. Limtao, Alan D. Baldwin, Gregory C. Loney
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Patent number: 10061107Abstract: Systems and techniques for an optical scanning microscope and/or other appropriate imaging system includes components for scanning and collecting focused images of a tissue sample and/or other object disposed on a slide. The focusing system described herein provides for determining best focus for each snapshot as a snapshot is captured, which may be referred to as “on-the-fly focusing.” The devices and techniques provided herein lead to significant reductions in the time required for forming a digital image of an area in a pathology slide and provide for the creation of high quality digital images of a specimen at high throughput.Type: GrantFiled: February 11, 2015Date of Patent: August 28, 2018Assignee: Ventana Medical Systems, Inc.Inventors: Gregory C. Loney, Glenn Stark, Chris Todd, Bikash Sabata
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Publication number: 20170247745Abstract: The present disclosure provides systems and methods for the optical detection of a plurality of labeled substrates in an assay. The various aspects of the optical detection systems enable the simultaneous detection of the plurality of labeled substrates. These systems are particularly useful in the detection of nucleic acids during an amplifications reaction.Type: ApplicationFiled: September 9, 2015Publication date: August 31, 2017Inventors: Kimberly M. SHULTZ, Alan D. BALDWIN, Kate L. BECHTEL, Adam DE LA ZERDA, Jesus CHING, Gregory C. LONEY
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Publication number: 20170173588Abstract: Cartridge-based thermocyclers can include cartridges that are configured to move a fluid between distinct chambers. In some cases, the cartridge-based thermocyclers can be used for thermocycling a sample fluid comprising a deoxyribonucleic acid (DNA) target to perform polymerase chain reaction (PCR). Individual chambers can be heated, cooled, and/or compressed to mix fluid within the chamber or to propel fluid in the chamber into another chamber. The cartridges can have a laminate construction. The cartridges can be configured to enable multiplexed thermocycling and/or detection.Type: ApplicationFiled: March 9, 2015Publication date: June 22, 2017Inventors: Hamilton R. TANG, Adam DE LA ZERDA, Kenneth I. LI, Kevin M. LIMTAO, Alan D. BALDWIN, Gregory C. LONEY
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Patent number: 9575301Abstract: Systems and techniques for an optical scanning microscope and/or other appropriate imaging system includes components for scanning and collecting focused images of a tissue sample and/or other object disposed on a slide. The focusing system described herein provides for determining best focus for each snapshot as a snapshot is captured, which may be referred to as “on-the-fly focusing.” The devices and techniques provided herein lead to significant reductions in the time required for forming a digital image of an area in a pathology slide and provide for the creation of high quality digital images of a specimen at high throughput.Type: GrantFiled: February 11, 2015Date of Patent: February 21, 2017Assignee: Ventana Medical Systems, Inc.Inventors: Gregory C. Loney, Glenn Stark, Chris Todd, Bikash Sabata
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Publication number: 20150153555Abstract: Systems and techniques for an optical scanning microscope and/or other appropriate imaging system includes components for scanning and collecting focused images of a tissue sample and/or other object disposed on a slide. The focusing system described herein provides for determining best focus for each snapshot as a snapshot is captured, which may be referred to as “on-the-fly focusing.” The devices and techniques provided herein lead to significant reductions in the time required for forming a digital image of an area in a pathology slide and provide for the creation of high quality digital images of a specimen at high throughput.Type: ApplicationFiled: February 11, 2015Publication date: June 4, 2015Inventors: Gregory C. Loney, Glenn Stark, Chris Todd, Bikash Sabata
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Publication number: 20150153552Abstract: Systems and techniques for an optical scanning microscope and/or other appropriate imaging system includes components for scanning and collecting focused images of a tissue sample and/or other object disposed on a slide. The focusing system described herein provides for determining best focus for each snapshot as a snapshot is captured, which may be referred to as “on-the-fly focusing.” The devices and techniques provided herein lead to significant reductions in the time required for forming a digital image of an area in a pathology slide and provide for the creation of high quality digital images of a specimen at high throughput.Type: ApplicationFiled: February 11, 2015Publication date: June 4, 2015Inventors: Gregory C. Loney, Glenn Stark, Chris Todd, Bikash Sabata
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Publication number: 20150153556Abstract: Systems and techniques for an optical scanning microscope and/or other appropriate imaging system includes components for scanning and collecting focused images of a tissue sample and/or other object disposed on a slide. The focusing system described herein provides for determining best focus for each snapshot as a snapshot is captured, which may be referred to as “on-the-fly focusing.” The devices and techniques provided herein lead to significant reductions in the time required for forming a digital image of an area in a pathology slide and provide for the creation of high quality digital images of a specimen at high throughput.Type: ApplicationFiled: February 11, 2015Publication date: June 4, 2015Inventors: Gregory C. Loney, Glenn Stark, Chris Todd, Bikash Sabata
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Patent number: 9036255Abstract: Systems and techniques for an optical scanning microscope and/or other appropriate imaging system includes components for scanning and collecting focused images of a tissue sample and/or other object disposed on a slide. The focusing system described herein provides for determining best focus for each snapshot as a snapshot is captured, which may be referred to as “on-the-fly focusing.” The devices and techniques provided herein lead to significant reductions in the time required for forming a digital image of an area in a pathology slide and provide for the creation of high quality digital images of a specimen at high throughput.Type: GrantFiled: April 11, 2012Date of Patent: May 19, 2015Assignee: Ventana Medical Systems, Inc.Inventors: Gregory C. Loney, Glenn Stark, Chris Todd, Bikash Sabata
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Patent number: 9001422Abstract: In an automated process of handling slides, such as in an imaging system, a slide hander must be able to get a hold of, lift up, and move slides, with tissues samples thereon, to multiple locations quickly and efficiently. To perform this function, the arm of the slide handler needs to be free to move from one location to the next and to advantageously respond in the event of encountering any unexpected or misplaced objects and/or other obstacles without jamming, being damaged and/or causing damage to a slide. A system described herein provides for the use of a slide handler having a crash head assembly with a spring-loaded flexible joint that may disengage if an unexpected obstacle is encountered and spring back to its proper location once the obstacle is cleared. Additionally, because the crash head assembly can flex, it is less likely to break or chip the glass slides.Type: GrantFiled: February 28, 2013Date of Patent: April 7, 2015Assignee: Ventana Medical Systems, Inc.Inventors: Michael T. Taylor, Gregory C. Loney
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Publication number: 20140240824Abstract: In an automated process of handling slides, such as in an imaging system, a slide hander must be able to get a hold of, lift up, and move slides, with tissues samples thereon, to multiple locations quickly and efficiently. To perform this function, the arm of the slide handler needs to be free to move from one location to the next and to advantageously respond in the event of encountering any unexpected or misplaced objects and/or other obstacles without jamming, being damaged and/or causing damage to a slide. A system described herein provides for the use of a slide handler having a crash head assembly with a spring-loaded flexible joint that may disengage if an unexpected obstacle is encountered and spring back to its proper location once the obstacle is cleared. Additionally, because the crash head assembly can flex, it is less likely to break or chip the glass slides.Type: ApplicationFiled: February 28, 2013Publication date: August 28, 2014Applicant: Ventana Medical Systems, Inc.Inventors: Michael T. TAYLOR, Gregory C. LONEY
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Publication number: 20140204196Abstract: Systems and techniques for an optical scanning microscope and/or other appropriate imaging system includes components for scanning and collecting focused images of a tissue sample and/or other object disposed on a slide. The focusing system described herein provides for determining best focus for each snapshot as a snapshot is captured, which may be referred to as “on-the-fly focusing.” Best focus may be determined using an error function generated according to movement of a dither focusing lens. The devices and techniques provided herein lead to significant reductions in the time required for forming a digital image of an area in a pathology slide and provide for the creation of high quality digital images of a specimen at high throughput.Type: ApplicationFiled: August 21, 2012Publication date: July 24, 2014Applicant: VENTANA MEDICAL SYSTEMS, INC.Inventors: Gregory C. Loney, Glenn Stark