Abstract: Among the various aspects of the present disclosure is the provision of methods for producing radioisotopes and improving the specific activity of radioisotopes (e.g., Cu-64 chloride). As described herein, the method includes matching of the target material and the proton beam strike area, resulting in improved specific activity while reducing the amount of target material used.

Abstract: Among the various aspects of the present disclosure is the provision of methods for producing radioisotopes and improving the specific activity of radioisotopes (e.g., Cu-64 chloride). As described herein, the method includes matching of the target material and the proton beam strike area or the proton beam strike shape, resulting in improved specific activity while reducing the amount of target material used.

Abstract: Among the various aspects of the present disclosure is the provision of systems for producing radioisotopes and improving the specific activity of radioisotopes (e.g., Cu-64 chloride). As described herein, the system includes a target material area or target material shape that matches the proton beam strike area or proton beam strike shape, resulting in optimal thickness with less target material required.

Abstract: A novel method for separating an irradiated 60Cu or 61Cu or 64Cu respectively from a composition containing 60Ni or 61Ni or 64Ni respectively therein comprises dissolving the irradiated 60Cu or 61Cu or 64Cu in a solvent acid to form an acidic solubilized composition, feeding the acidic solubilized composition onto an ion exchange column and removing an eluent comprising 60Ni or 61Ni or 64Ni ions. In an aspect the eluent is further processed for 60Ni or 61Ni or 64Ni recovery and recycling to prepare future targets. In an aspect 60Cu or 61Cu or 64Cu respectively is temporarily trapped into the ion exchange column resin and held for subsequent recovery by addition of 0.5 N HCl to elute out the 60Cu or 61Cu or 64Cu for further use or labeling. An enhanced process for labeling compounds with highly purified 60Cu, 61Cu or 64Cu comprises loading 60Cu, 61Cu and 64Cu elute onto a concentrating cartridge, collecting the 0.