Abstract: Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions.

Abstract: Disclosed is a surgical fixation device to mount on bone. This device does not utilize screws and achieves stability via applying force to the inner wall of the bore and is therefore faster, easier to use, and less user dependent. The device facilitates fast, easy anchoring system for use with other devices that require rigid fixation to bone. The device provides for intermittent mounting of tools, equipment, and/or accessories to a cylindrical bore in bone for use in surgical applications without compromising surrounding bine structure such as done by the use of bone screws. Rigid fixation to bone is a common requirement for surgical procedures for placement of tools, monitoring systems, positional systems, or used as fiducial markers. The present fixation device removably mounts on bone without the disadvantages associated with bone screws and other fixation devices.