Abstract: Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions.

Abstract: A data modeling and analytics platform augments and annotates content captured from a user's online interactions and other documents. The data modeling and analytics platform is performed within a machine learning and artificial intelligence-based processing environment that enables observability, explainability, and data analytics for dynamic information discovery over time within a user library that includes files representing the online interactions and documents containing information of user interest.

Abstract: A thin brick panel assembly for forming a brick facing on a building includes a backing member formed from of a single sheet of material which is adapted to properly retain individual thin brick tiles, and support clips utilized in supporting the completed brick facing. The backing member has a uniform cross-section throughout its entire length, and provides channels which allow the thin brick tiles to lay uniformly across each row. Support clips secure the completed brick facing to an underlying support structure of the building.

Abstract: A thin brick panel assembly for forming a brick facing on a building structure. The brick panel assembly includes a backing member formed from a single sheet of material, which is adapted to properly retain individual thin brick tiles. The backing member has a generally uniform cross-section throughout its entire length, providing channels which allow the thin brick tiles to lay uniformly across each row. The channels are defined by retaining bars which hold the thin brick tiles in place. The retaining bars include mortar lock notches, which are adapted to provide a dovetail connection between the mortar and the backing board, as well as a path for moisture and water to escape from the brick panel assembly.

Abstract: A thin brick panel assembly for forming a brick facing on a building includes a backing member formed from of a single sheet of material which is adapted to properly retain individual thin brick tiles, and support clips utilized in supporting the completed brick facing. The backing member has a uniform cross-section throughout its entire length, and provides channels which allow the thin brick tiles to lay uniformly across each row. Support clips secure the completed brick facing to an underlying support structure of the building.