Patents by Inventor Gregory Kaler

Gregory Kaler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • APPARATUS FOR MEASURING EFFECT OF TEST COMPOUNDS ON BIOLOGICAL OBJECTS
    Publication number: 20090186374
    Abstract: An apparatus and method for real-time measurement of an effect of different concentrations of a test compound or series of test compounds on living cells, in which a flow of cell suspension is combined with a flow of the test compound and a cellular response of the living cells is repeatedly measured by a detector along a length of a detection zone where the cell suspension-test compound mixture is situated. The apparatus may be used in automated screening of libraries of compounds, and is capable of real-time variation of concentrations of test compounds and generation of three-dimensional dose/response/time profiles within a short timespan.
    Type: Application
    Filed: February 21, 2008
    Publication date: July 23, 2009
    Applicant: Etogen Scientific
    Inventors: Alex Okun, Gregory Kaler, Ilya Okun
  • Cell flow apparatus and method for real-time measurements of patient cellular responses
    Patent number: 6958221
    Abstract: The present invention is directed to a method for determining the effect of each of a plurality of test agents on cells from a subject, and a method to profile patient cell responses to test agents.
    Type: Grant
    Filed: December 23, 2002
    Date of Patent: October 25, 2005
    Assignee: Caliper Life Sciences, Inc.
    Inventors: Pandi Veerapandian, Gregory Kaler
  • Cell flow apparatus and method for real-time measurements of patient cellular responses
    Publication number: 20030129669
    Abstract: The present invention is directed to a method for determining the effect of each of a plurality of test agents on cells from a subject, and a method to profile patient cell responses to test agents.
    Type: Application
    Filed: December 23, 2002
    Publication date: July 10, 2003
    Inventors: Pandi Veerapandian, Gregory Kaler
  • Fluorescent dyes
    Publication number: 20030100762
    Abstract: Compounds of the formula (I) are provided, wherein n is 1 or 2, Q1 and Q2 are each individually selected from the group consisting of O and S, X is H or halogen, and R1, R2, R3 and R4 are each individually selected from the group consisting of hydrogen and uncharged groups having from 1 to about 20 carbon atoms. Methods of making such compounds are also described. Such compounds are useful as fluorescent dyes.
    Type: Application
    Filed: August 23, 2002
    Publication date: May 29, 2003
    Inventors: Gregory Kaler, Clinton A. Threlfall, Channa Basava, Ilya Okun
  • Cell flow apparatus and method for real-time measurements of patient cellular responses
    Patent number: 6558916
    Abstract: The present invention is directed to a method for determining the effect of each of a plurality of test agents on cells from a subject, and a method to profile patient cell responses to test agents.
    Type: Grant
    Filed: February 7, 2001
    Date of Patent: May 6, 2003
    Assignee: Axiom Biotechnologies, Inc.
    Inventors: Pandi Veerapandian, Gregory Kaler
  • Cell flow apparatus and method for real-time measurements of patient cellular responses
    Publication number: 20020086340
    Abstract: The present invention is directed to a method for determining the effect of each of a plurality of test agents on cells from a subject, and a method to profile patient cell responses to test agents.
    Type: Application
    Filed: February 7, 2001
    Publication date: July 4, 2002
    Inventors: Pandi Veerapandian, Gregory Kaler
  • Methods of registering trans-membrane electric potentials
    Patent number: 6287758
    Abstract: Sensitive methods for identifying compounds having biological activity comprising combining living cells with two fluorescent membrane permeable ionic dyes having the same charge sign, the first of which has an emission spectrum which overlaps the excitation spectrum of the second fluorescent membrane penetrative dye. The fluorescence is then induced by illuminating the dyes at a wavelength corresponding to the excitation spectrum of the first fluorescent dye and emission is then registered at a wavelength corresponding to the emission spectrum of the second fluorescent dye (FRET). The change in the FRET is indicative of a modulation of cell membrane potential by the biologically active compounds.
    Type: Grant
    Filed: March 23, 2000
    Date of Patent: September 11, 2001
    Assignee: Axiom Biotechnologies, Inc.
    Inventors: Ilya Okun, Alex Okun, Gregory Kaler