Abstract: Methods for monitoring subject compliance with a prescribed treatment regimen are disclosed. In an embodiment, the method comprises measuring a drug level in oral fluid of a subject and normalizing the measured drug level as a function of one or more parameters associated with the subject. Embodiments of the methods Use patient derived parameters together with the prescribed dose to affect a transformed and normalized value that can be compared to a transformed and normalized standard distribution derived from a body of collected oral fluid test results.

Abstract: The present disclosure provides methods for monitoring subject (e.g., patient) adherence to quetiapine therapy, for example as a component of treating a subject for a mental health disorder such as schizophrenia, bipolar disorder or major depressive disorder.

Abstract: Methods for helping to monitor subject adherence with a prescribed antipsychotic drug treatment regimen are disclosed.

Abstract: Methods for helping to monitor subject adherence with a prescribed antipsychotic drug treatment regimen are disclosed.

Abstract: The present disclosure provides methods for monitoring subject (e.g., patient) adherence to lurasidone therapy, for example as a component of treating a subject for a mental health disorder such as schizophrenia.

Abstract: The present disclosure provides methods for monitoring subject (e.g., patient) adherence to lurasidone therapy, for example as a component of treating a subject for a mental health disorder such as schizophrenia.

Abstract: The present disclosure provides methods for monitoring subject (e.g., patient) adherence to Haldol therapy, for example as a component of treating a subject for a mental health disorder such as schizophrenia.

Abstract: Methods for monitoring subject compliance with a prescribed treatment regimen are disclosed. In an embodiment, the method comprises measuring a drug or metabolite level in urine of a subject and normalizing the measured drug or inverse of the metabolite level as a function of one or more parameters associated with the subject followed by transformation of the normalized data using the natural log of the normalized data. Embodiments of the methods use patient derived parameters together with the prescribed dose to affect a normalized and transformed value that can be compared to a normalized and transformed standard distribution derived from a body of collected urine fluid test results.

Abstract: The present disclosure provides methods of hydrolyzing a drug-glucuronide conjugate, and methods of determining a drug concentration comprising hydrolyzing a drug-glucuronide conjugate in the presence of a water miscible organic solvent that can simultaneously prevent bacterial growth in the enzyme and prevent analyte adsorption.

Abstract: The present disclosure provides methods for monitoring subject (e.g., patient) adherence to quetiapine therapy, for example as a component of treating a subject for a mental health disorder such as schizophrenia, bipolar disorder or major depressive disorder.

Abstract: Methods for monitoring subject compliance with a prescribed treatment regimen are disclosed. In an embodiment, the method comprises measuring a drug and a metabolite level in fluid of a subject and transforming the ratio of the measured drug levels and comparing the subsequent Drug Ratio with a likewise transformed Data Set of drug/metabolite ratios. Using the transformed ratio of parent drug to metabolite eliminates the need for further adjustments using patient specific parameters and other transforming/normalizing quantities.

Abstract: Methods for helping to monitor subject adherence with a prescribed antipsychotic drug treatment regimen are disclosed.

Abstract: Methods for helping to monitor subject adherence with a prescribed antipsychotic drug treatment regimen are disclosed.

Abstract: The present disclosure provides methods for monitoring subject (e.g., patient) adherence to lurasidone therapy, for example as a component of treating a subject for a mental health disorder such as schizophrenia.

Abstract: Methods for helping to monitor subject adherence with a prescribed antipsychotic drug treatment regimen are disclosed.

Abstract: A polymorph of brimonidine pamoate having the formula exhibits characteristics disclosed herein. The polymorph is included in a composition, device, or implant for use in the treatment or control of elevated intraocular pressure or in the neuroprotection of components of a neurological tissue to prevent progressive degeneration of such components. In particular, such a composition, device, or implant can be used to provide neuroprotection to cells and components of the optic nerve system.

Abstract: A polymorph of brimonidine pamoate having the formula exhibits characteristics disclosed herein. The polymorph is included in a composition, device, or implant for use in the treatment or control of elevated intraocular pressure or in the neuroprotection of components of a neurological tissue to prevent progressive degeneration of such components. In particular, such a composition, device, or implant can be used to provide neuroprotection to cells and components of the optic nerve system.

Abstract: A brimonidine pamoate polymorph exhibits characteristics disclosed herein, wherein the brimonidine pamoate has the following formula The polymorph is included in a composition, device, or implant for use in the treatment or control of elevated intraocular pressure or in the neuroprotection of components of a neurological tissue to prevent progressive degeneration of such components. In particular, such a composition, device, or implant can be used to provide neuroprotection to cells and components of the optic nerve system.

Abstract: The invention is in the field of computer implemented systems and methods for generating a profile of an investor's risk tolerance, providing automated investment allocation advice based on the risk tolerance of the investor, generating at least one list of investments for the portfolio of the investor, allowing for review of the at least one list of investments and information relating to historic and/or hypothetical performance and a description of asset selection methodology, performing automated electronic execution of transactions pertaining the investments, maintenance and monitoring of investment portfolios, and rebalancing of investment portfolios.

Abstract: A brimonidine pamoate polymorph exhibits characteristics disclosed herein. The polymorph is included in a composition, device, or implant for use in the treatment or control of elevated intraocular pressure or in the neuroprotection of components of a neurological tissue to prevent progressive degeneration of such components. In particular, such a composition, device, or implant can be used to provide neuroprotection to cells and components of the optic nerve system.