Patents by Inventor Gregory L. Sabatino

Gregory L. Sabatino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR TREATING COLLAGEN-MEDIATED DISEASES
    Publication number: 20230158127
    Abstract: A drug product comprising a combination of highly purified collagenase I and collagenase II from Clostridium histolyticum is disclosed. The drug product includes collagenase I and collagenase II in a ratio of about 1 to 1, with a purity of greater than at least 95%. The invention further disclosed improved fermentation and purification processes for preparing the said drug product.
    Type: Application
    Filed: September 14, 2022
    Publication date: May 25, 2023
    Inventors: Gregory L. Sabatino, Benjamin J. Del Tito, JR., Phillip J. Bassett, Hazel A. Tharia, Antony G. Hitchcock, Bo Yu, Thomas L. Wegman
  • COMPOSITIONS AND METHODS FOR TREATING COLLAGEN-MEDIATED DISEASES
    Publication number: 20210106659
    Abstract: A drug product comprising a combination of highly purified collagenase I and collagenase II from Clostridium histolyticum is disclosed. The drug product includes collagenase I and collagenase II in a ratio of about 1 to 1, with a purity of greater than at least 95%. The invention further disclosed improved fermentation and purification processes for preparing the said drug product.
    Type: Application
    Filed: October 2, 2020
    Publication date: April 15, 2021
    Inventors: Gregory L. Sabatino, Benjamin J. Del Tito, JR., Phillip J. Bassett, Hazel A. Tharia, Antony G. Hitchcock, Bo Yu, Thomas L. Wegman
  • COMPOSITIONS AND METHODS FOR TREATING COLLAGEN-MEDIATED DISEASES
    Publication number: 20170087229
    Abstract: A drug product comprising a combination of highly purified collagenase I and collagenase II from Clostridium histolyticum is disclosed. The drug product includes collagenase I and collagenase II in a ratio of about 1 to 1, with a purity of greater than at least 95%. The invention further disclosed improved fermentation and purification processes for preparing the said drug product.
    Type: Application
    Filed: May 20, 2016
    Publication date: March 30, 2017
    Inventors: Gregory L. Sabatino, Benjamin J. Del Tito, JR., Phillip J. Bassett, Hazel A. Tharia, Antony G. Hitchcock, Bo Yu, Thomas L. Wegman
  • COMPOSITIONS AND METHODS FOR TREATING COLLAGEN-MEDIATED DISEASES
    Publication number: 20160000889
    Abstract: A drug product comprising a combination of highly purified collagenase I and collagenase II from Clostridium histolyticum is disclosed. The drug product includes collagenase I and collagenase II in a ratio of about 1 to 1, with a purity of greater than at least 95%. The invention further disclosed improved fermentation and purification processes for preparing the said drug product.
    Type: Application
    Filed: February 4, 2015
    Publication date: January 7, 2016
    Inventors: Gregory L. Sabatino, Benjamin J. Del Tito, JR., Phillip J. Bassett, Hazel A. Tharia, Antony G. Hitchcock, Bo Yu, Thomas L. Wegman
  • COMPOSITIONS AND METHODS FOR TREATING COLLAGEN-MEDIATED DISEASES
    Publication number: 20140004094
    Abstract: A drug product comprising a combination of highly purified collagenase I and collagenase II from Clostridium histolyticum is disclosed. The drug product includes collagenase I and collagenase II in a ratio of about 1 to 1, with a purity of greater than at least 95%. The invention further disclosed improved fermentation and purification processes for preparing the said drug product.
    Type: Application
    Filed: December 13, 2012
    Publication date: January 2, 2014
    Inventors: Gregory L. Sabatino, Benjamin J. Del Tito, JR., Phillip J. Bassett, Hazel A. Tharia, Antony G. Hitchcock, Bo Yu, Thomas L. Wegman
  • COMPOSITIONS AND METHODS FOR TREATING COLLAGEN-MEDIATED DISEASES
    Publication number: 20110243920
    Abstract: A drug product comprising a combination of highly purified collagenase I and collagenase II from Colostridium histolyticum is disclosed. The drug product includes collagenase I and collagenase II in a ratio of about 1 to 1, with a purity of greater than at least 95%. The invention further disclosed improved fermentation and purification processes for preparing the said drug product.
    Type: Application
    Filed: April 12, 2011
    Publication date: October 6, 2011
    Inventors: Gregory L. Sabatino, Benjamin J. Del Tito, JR., Phillip J. Bassett, Hazel A. Tharia, Antony G. Hitchcock
  • Compositions and Methods for Treating Collagen-Mediated Diseases
    Publication number: 20110243908
    Abstract: A drug product comprising a combination of highly purified collagenase I and collagenase II from Colostridium histolyticum is disclosed. The drug product includes collagenase I and collagenase II in a ratio of about 1 to 1, with a purity of greater than at least 95%. The invention further disclosed improved fermentation and purification processes for preparing the said drug product.
    Type: Application
    Filed: April 12, 2011
    Publication date: October 6, 2011
    Inventors: Gregory L. Sabatino, Benjamin J. Del Tito, JR., Phillip J. Bassett, Hazel A. Tharia, Antony G. Hitchcock
  • Compositions and Methods for Treating Collagen-Mediated Diseases
    Publication number: 20110243919
    Abstract: A drug product comprising a combination of highly purified collagenase I and collagenase II from Colostridium histolyticum is disclosed. The drug product includes collagenase I and collagenase II in a ratio of about 1 to 1, with a purity of greater than at least 95%. The invention further disclosed improved fermentation and purification processes for preparing the said drug product.
    Type: Application
    Filed: April 12, 2011
    Publication date: October 6, 2011
    Inventors: Gregory L. Sabatino, Benjamin J. Del Tito, JR., Phillip J. Bassett, Hazel A. Tharia, Antony G. Hitchcock
  • Compositions and Methods for Treating Collagen-Mediated Diseases
    Publication number: 20110243909
    Abstract: A drug product comprising a combination of highly purified collagenase I and collagenase II from Colostridium histolyticum is disclosed. The drug product includes collagenase I and collagenase II in a ratio of about 1 to 1, with a purity of greater than at least 95%. The invention further disclosed improved fermentation and purification processes for preparing the said drug product.
    Type: Application
    Filed: April 12, 2011
    Publication date: October 6, 2011
    Inventors: Gregory L. Sabatino, Benjamin J. Del Tito, JR., Phillip J. Bassett, Hazel A. Tharia, Antony G. Hitchcock
  • Compositions and Methods for Treating Collagen-Mediated Diseases
    Publication number: 20110189163
    Abstract: A drug product comprising a combination of highly purified collagenase I and collagenase II from Colostridium histolyticum is disclosed. The drug product includes collagenase I and collagenase II in a ratio of about 1 to 1, with a purity of greater than at least 95%. The invention further disclosed improved fermentation and purification processes for preparing the said drug product.
    Type: Application
    Filed: April 12, 2011
    Publication date: August 4, 2011
    Inventors: Gregory L. Sabatino, Benjamin J. Del Tito, JR., Phillip J. Bassett, Hazel A. Tharia, Antony G. Hitchcock
  • Compositions and Methods for Treating Collagen-Mediated Diseases
    Publication number: 20110189153
    Abstract: A drug product comprising a combination of highly purified collagenase I and collagenase II from Colostridium histolyticum is disclosed. The drug product includes collagenase I and collagenase II in a ratio of about 1 to 1, with a purity of greater than at least 95%. The invention further disclosed improved fermentation and purification processes for preparing the said drug product.
    Type: Application
    Filed: April 12, 2011
    Publication date: August 4, 2011
    Inventors: Gregory L. Sabatino, Benjamin J. Del Tito, Phillip J. Bassett, Hazel A. Tharia, Antony G. Hitchcock
  • COMPOSITIONS AND METHODS FOR TREATING COLLAGEN-MEDIATED DISEASES
    Publication number: 20110158972
    Abstract: A drug product comprising a combination of highly purified collagenase I and collagenase II from Clostridium histolyticum is disclosed. The drug product includes collagenase I and collagenase II in a ratio of about 1 to 1, with a purity of greater than at least 95%. The invention further disclosed improved fermentation and purification processes for preparing the said drug product.
    Type: Application
    Filed: August 30, 2010
    Publication date: June 30, 2011
    Inventors: Gregory L. Sabatino, Benjamin J. Del Tito, JR., Phillip J. Bassett, Hazel A. Tharia, Antony G. Hitchcock
  • COMPOSITIONS AND METHODS FOR TREATING COLLAGEN-MEDIATED DISEASES
    Publication number: 20100330065
    Abstract: A drug product comprising a combination of highly purified collagenase I and collagenase II from Colostridium histolyticum is disclosed. The drug product includes collagenase I and collagenase II in a ratio of about 1 to 1, with a purity of greater than at least 95%. The invention further disclosed improved fermentation and purification processes for preparing the said drug product.
    Type: Application
    Filed: July 16, 2010
    Publication date: December 30, 2010
    Inventors: Gregory L. SABATINO, Benjamin J. Del Tito, JR., Phillip J. Bassett, Hazel A. Tharia, Antony G. Hitchcock, Bo Yu, Thomas L. Wegman
  • Compositions and methods for treating collagen-mediated diseases
    Patent number: 7811560
    Abstract: A drug product comprising a combination of highly purified collagenase I and collagenase II from Colostridium histolyticum is disclosed. The drug product includes collagenase I and collagenase II in a ratio of about 1 to 1, with a purity of greater than at least 95%. The invention further disclosed improved fermentation and purification processes for preparing the said drug product.
    Type: Grant
    Filed: January 29, 2007
    Date of Patent: October 12, 2010
    Assignee: Auxilium US Holdings, LLC
    Inventors: Gregory L. Sabatino, Benjamin J. Del Tito, Jr., Phillip J. Bassett, Hazel A. Tharia, Antony G. Hitchcock
  • COMPOSITIONS AND METHODS FOR TREATING COLLAGEN-MEDIATED DISEASES
    Publication number: 20100233151
    Abstract: A drug product comprising a combination of highly purified collagenase I and collagenase II from Colostridium histolyticum is disclosed. The drug product includes collagenase I and collagenase II in a ratio of about 1 to 1, with a purity of greater than at least 95%. The invention further disclosed improved fermentation and purification processes for preparing the said drug product.
    Type: Application
    Filed: April 13, 2010
    Publication date: September 16, 2010
    Inventors: Gregory L. SABATINO, Benjamin J. Del Tito, JR., Phillip J. Bassett, Hazel A. Tharia, Antony G. Hitchcock, Bo Yu, Thomas L. Wegman
  • PRODUCTION OF RECOMBINANT COLLAGENASES COLG AND COLH IN ESCHERICHIA COLI
    Publication number: 20080233614
    Abstract: The present invention provides codon-optimized genes designed to help maximize heterologous protein expression level. The present invention provides codon-optimized recombinant colG and colH collagenase sequences.
    Type: Application
    Filed: February 11, 2008
    Publication date: September 25, 2008
    Inventors: Rocky M. Cranenburgh, Gregory L. Sabatino, Benjamin J. Del Tito