Abstract: An automatic recoiler for converting a firearm into a simulator includes a sealed cylinder with a piston. A piston rod extends from the piston through the rebound chamber and out of the cylinder. A gas block at the end of the rebound chamber has a pressure relieve valve for allowing fluid to enter and exit. The cylinder includes an inlet port in communication with the compression chamber. The piston rod has an end face sized to contact a front surface of the slide for recoiling the slide backward. A power source moves the piston thereby extending the piston rod from the cylinder. A controller controls the power source thereby controlling the extension of the piston rod from the cylinder. Whereby, when a user presses the trigger, the controller controls the power source to move the piston thereby extending the piston rod from the cylinder and recoiling the slide backward.

Abstract: An automatic recoiler for converting a firearm into a simulator includes a sealed cylinder with a piston. A piston rod extends from the piston through the rebound chamber and out of the cylinder. A gas block at the end of the rebound chamber has a pressure relieve valve for allowing fluid to enter and exit. The cylinder includes an inlet port in communication with the compression chamber. The piston rod has an end face sized to contact a front surface of the slide for recoiling the slide backward. A power source moves the piston thereby extending the piston rod from the cylinder. A controller controls the power source thereby controlling the extension of the piston rod from the cylinder. Whereby, when a user presses the trigger, the controller controls the power source to move the piston thereby extending the piston rod from the cylinder and recoiling the slide backward.

Abstract: The present invention concerns methods for stimulating the growth and repair of bone and cartilage using synthetic triterpenoids and tricyclic-bis-enones. Examples of suitable triterpenoids include CDDO, CDDO-Me, CDDO-Im, and CDDO-Ethylamide. Examples of tricyclic-bis-enones include TBE-31 and TBE-34.

Abstract: The present invention concerns methods for stimulating the growth and repair of bone and cartilage using synthetic triterpenoids and tricyclic-bis-enones. Examples of suitable triterpenoids include CDDO, CDDO-Me, CDDO-Im, and CDDO-Ethylamide. Examples of tricyclic-bis-enones include TBE-31 and TBE-34.

Abstract: Compounds of the formula wherein X in each of formulas (1) and (2) represents a substituted or unsubstituted alkylene, alkenylene, or alkynylene linker of 2-6C; Y is of the formula or a stereoisomer thereof, wherein R1 is substituted or unsubstituted alkyl; each R2 is independently H, hydroxy, alkoxy (1-6C) or lower alkyl (1-4C); R3 is H, hydroxy, or alkoxy (1-6C); or Y is of the formula wherein each n is 1, Z is N, K comprises a substituted or unsubstituted aromatic carbocyclic or heterocyclic ring system which may optionally be spaced from the linkage position shown in formula (7) by a linker of 1-2C, or in formula (7), Z may be spaced from the carbon bonded to X by ?CR6— wherein R6 is H or linear, branded or cyclic alkyl (1-6C), R5 is H or linear, branched or cyclic alkyl, and R? represents a cation, H or a substituted or unsubstituted alkyl group of 1-6C, promote bone formation and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyro

Abstract: A therapeutically effective amount of an antibody for a compound selected from the group consisting of PTHrp, TGF?, IL-1?, IL-1?, IL-6, Lymphotoxin, TNF, PGE; 1,25 dihydroxy vitamin D3 and an antigenic fragment thereof used in the treatment of cancer metastasis to bone and cancer cell growth in bone as well as osteolysis and symptomatic sequelae thereof. An antibody immunoreactive with parathyroid hormone-related protein (PTHrp) is particularly preferred. Antibodies with human characteristics are included in the invention for application of the invention method to human subjects. Also, the antibody can be administered in an injectable is formulation in combination with a therapeutically effective amount of a bisphosphonate or pyrophosphate having the general structure formula wherein X is a linking moiety allowing for the interconnection of the phosphonate groups, and pharmaceutically acceptable salts, hydrates and partial hydrates thereof.

Abstract: Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or “linker” defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 Å, are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.