Abstract: Methods for delivery of a biologic agent to the dermis or superficial muscles by topical application of the agent are provided. The methods comprise, in one embodiment, treating or conditioning a skin area to disrupt the stratum corneum in the skin area to define a treated skin area and applying a formulation comprising a biologic agent to the treated skin area.

Abstract: Formulations, methods, and kits comprising at least one Clostridium toxin derivative and at least one chemical depolarizing agent suitable for inducing local, partial or complete muscle paralysis or muscle denervation in a subject are described.

Abstract: Methods for delivery of a biologic agent to the dermis or superficial muscles by topical application of the agent are provided. The methods comprise, in one embodiment, treating or conditioning a skin area to disrupt the stratum corneum in the skin area to define a treated skin area and applying a formulation comprising a biologic agent to the treated skin area.

Abstract: The present invention relates to a set of tools and accessories used for properly positioning a stemmed humeral component, and/or a humeral stem provisional, within a canal in the humerus. The set of tools and accessories includes one or more fin clamps that are configured to be temporarily attached to a fin on the humeral component or the provisional; a ruler that is configured to be attached to the arm of the fin clamp, a fixation pin and pin driver configured to be used with the other tools for marking a position on the humerus; and one or more sleeves that are configured to slide over the stem of the humeral stem provisional to maintain it in the desired position.

Abstract: The present invention relates to a set of tools and accessories used for properly positioning a stemmed humeral component, and/or a humeral stem provisional, within a canal in the humerus. The set of tools and accessories includes one or more fin clamps that are configured to be temporarily attached to a fin on the humeral component or the provisional; a ruler that is configured to be attached to the arm of the fin clamp, a fixation pin and pin driver configured to be used with the other tools for marking a position on the humerus; and one or more sleeves that are configured to slide over the stem of the humeral stem provisional to maintain it in the desired position.

Abstract: The present invention relates to a set of tools and accessories used for properly positioning a stemmed humeral component, and/or a humeral stem provisional, within a canal in the humerus. The set of tools and accessories includes one or more fin clamps that are configured to be temporarily attached to a fin on the humeral component or the provisional; a ruler that is configured to be attached to the arm of the fin clamp, a fixation pin and pin driver configured to be used with the other tools for marking a position on the humerus; and one or more sleeves that are configured to slide over the stem of the humeral stem provisional to maintain it in the desired position.

Abstract: A method and apparatus for facilitating shoulder arthroplasty by providing a reference to establish version of the glenoid. In one form of the invention, a guide for positioning a guide pin to facilitate implantation of a glenoid prosthesis is provided. To properly position the guide pin, the guide is first oriented with respect to the scapula. A portion of the guide is positioned over the approximate center of the glenoid surface and another portion of the guide is positioned against the anterior surface of the scapula. After the guide is properly positioned, the guide pin is inserted through an aperture in the guide and anchored in the glenoid. Thereafter, the guide pin can serve as an alignment guide for other devices used to modify the glenoid surface. For example, a reamer having a cannulated central shaft can be placed over the guide pin and utilized to resurface the glenoid.

Abstract: A method and apparatus for facilitating shoulder arthroplasty by providing a reference to establish version of the glenoid. In one form of the invention, a guide for positioning a guide pin to facilitate implantation of a glenoid prosthesis is provided. To properly position the guide pin, the guide is first oriented with respect to the scapula. A portion of the guide is positioned over the approximate center of the glenoid surface and another portion of the guide is positioned against the anterior surface of the scapula. After the guide is properly positioned, the guide pin is inserted through an aperture in the guide and anchored in the glenoid. Thereafter, the guide pin can serve as an alignment guide for other devices used to modify the glenoid surface. For example, a reamer having a cannulated central shaft can be placed over the guide pin and utilized to resurface the glenoid.

Abstract: The present invention relates to a set of tools and accessories used for properly positioning a stemmed humeral component, and/or a humeral stem provisional, within a canal in the humerus. The set of tools and accessories includes one or more fin clamps that are configured to be temporarily attached to a fin on the humeral component or the provisional; a ruler that is configured to be attached to the arm of the fin clamp, a fixation pin and pin driver configured to be used with the other tools for marking a position on the humerus; and one or more sleeves that are configured to slide over the stem of the humeral stem provisional to maintain it in the desired position.