Abstract: Disclosed herein are surfactant free lyophilized formulations of antibody-drug conjugates (ADCs), such as anti-tissue factor ADCs, and reconstituted formulations, processes and uses thereof. The formulations are particularly suitable for an anti-TF ADC based on an auristatin derivative or other similarly hydrophobic drug. Typically, the excipients of the formulations comprise or consist of histidine, sucrose, trehalose, mannitol and glycine.

Abstract: The subject matter of this specification can be embodied in, among other things, a sensor that includes a first axial sensor housing portion having a first cross-sectional area, a second axial sensor housing portion arranged adjacent to the first axial sensor housing portion along the sensor axis and having a second cross-sectional area larger than the first cross-sectional area, and a face extending from the interior surface of the first axial sensor housing portion to the interior surface of the second axial sensor housing portion, a first buffer rod within the first axial sensor housing portion and having a first axial end and a second axial end, a second buffer rod within the second axial sensor housing portion and abutting the face, and having a third axial end and a fourth axial end, and an acoustic transceiver element acoustically mated to the second axial end and the third axial end.

Abstract: The subject matter of this specification can be embodied in, among other things, a fluid flow conditioning apparatus that includes a linear fluid conduit having a first tubular body defining a major axis and extending from a conduit inlet to a conduit outlet arranged opposite the conduit inlet, and configured with a predetermined flow geometry to define a linear fluid flow path along the major axis, a fluid inlet non-parallel to the linear fluid flow path, a first fluid flow conditioner configured to receive fluid flow, condition fluid flow, and redirect conditioned fluid flow along the linear fluid flow path along the major axis, a second fluid flow conditioner configured to receive fluid flow from the linear fluid flow path along the major axis, redirect fluid flow away from the linear fluid flow path, and condition fluid flow.

Abstract: The subject matter of this specification can be embodied in, among other things, a sensor that includes a first axial sensor housing portion having a first cross-sectional area, a second axial sensor housing portion arranged adjacent to the first axial sensor housing portion along the sensor axis and having a second cross-sectional area larger than the first cross-sectional area, and a face extending from the interior surface of the first axial sensor housing portion to the interior surface of the second axial sensor housing portion, a first buffer rod within the first axial sensor housing portion and having a first axial end and a second axial end, a second buffer rod within the second axial sensor housing portion and abutting the face, and having a third axial end and a fourth axial end, and an acoustic transceiver element acoustically mated to the second axial end and the third axial end.

Abstract: A system for dynamically adjusting insurance cover and an insurance premium associated with a policy of a client includes at least one computer and a processor. The system calculates a first cover amount by assessing a financial need which would result from occurrence of an insured event during a first period. A first premium is based on the first cover amount. The system then uses adjusted policy data, at least some of which it automatically generates, applicable to a second period of the policy, to calculate a second cover amount by assessing a financial need which would result from occurrence of an insured event during the second period. A second premium is based on the second cover amount. In this way, the system dynamically updates and calculates a premium for each period of the policy based on the financial need of the client in that particular period.

Abstract: A system for determining a reduced insurance premium includes at least one computer and a processor. The system receives a no-lapse discount request relating to a no-lapse period implemented in respect of a policy of a client. The system receives and/or accesses policy data which includes client data and non-client data relevant to the policy. A processor calculates a premium which covers a cost of risk and a cost of expenses associated with the policy and allows for a predefined profit allocation. The processor calculates the premium based on the policy data and on the assumption that the policy will not be cancelled or allowed to lapse during the no-lapse period. The cost of expenses and the predefined profit allocation for the policy are kept unchanged relative to another policy of the same type issued by the insurer, but in respect of which a no-lapse period does not apply.

Abstract: A system for determining a protection level and optimal insurance cover for a client includes at least one computer and a processor. The system receives current cover data for at least one current insurance policy associated with the client or input data in respect of a possible insurance policy for the client. The system generates benchmark cover data associated with proposed insurance cover for the client. A processor compares the current cover data, or the input data, with the benchmark cover data in order to determine a protection level of the client. Protection level data is generated. The protection level data may include a maximum protection level obtainable by the client if a premium indicated by the client as affordable is insufficient for the client to obtain a benchmark cover amount or benchmark cover level.

Abstract: An airframe 1 or part thereof comprises a set of modular cells 10, including a first cell 10A comprising a set of profiles 100 including: a first structural profile 100A, having a first length L1 and enclosing a first volume V1 providing a first passageway P1; and a second profile 100B, having a second length L2 and enclosing a second volume V2, wherein the first passageway P1 is arranged to receive the second profile 100B therein.

Abstract: A method of producing at least part of a structural frame of a vehicle, the method comprising: providing a support structure (300), the support structure (300) comprising: a plurality of elongate members (301); and one or more retaining members (208) configured to retain the elongate members (301); mounting a plurality of first structural components (206) to the support structure (300) by coupling the first structural components (206) to the elongate members (301) such that each first structural component (206) occupies a different respective position along the elongate members (301); and attaching a plurality of second structural components (204) to the first structural components (206), thereby coupling together the first structural components (206) to form the at least part of the structural frame of a vehicle.

Abstract: The subject matter of this specification can be embodied in, among other things, a position sensor system that includes a fluid effector that includes a housing having an inner surface defining a cavity, and a moveable body having a first face and a second face opposite the first face and configured to contact the inner surface and subdivide the cavity to define a first chamber and a second chamber, an acoustic transmitter system configured to emit a first emitted waveform toward the first face, and emit a second emitted waveform toward the second face, and an acoustic receiver system configured to detect a first reflected waveform based on a first reflection of the first emitted waveform based on the moveable body, and detect a second reflected waveform based on a second reflection of the second emitted waveform based on the moveable body.

Abstract: The subject matter of this specification can be embodied in, among other things, a method of sensing that includes measuring an acoustic impedance of a fluid, measuring a first time of flight in a first direction through the fluid, measuring a second time of flight in a second direction through the fluid, determining a mass fluid flow rate based on the measured acoustic impedance, the measured first time of flight, and the measured second time of flight, and providing the determined mass fluid flow rate.

Abstract: An airframe or a part thereof 3, for example a skin assembly or a profile such as a structural profile, comprises: a wall W having an aperture A therethrough, wherein the wall W provides a frame F surrounding, at least in part, the aperture A; a panel P conforming with the aperture A; and wherein the airframe or the part 3 thereof is configurable in: a first configuration, wherein the panel P and the frame F are mutually spaced apart; and a second configuration, wherein the panel P is received in the frame F and wherein the frame F resists movement of the panel P in two or three mutually orthogonal directions.

Abstract: An airframe 1 or part thereof comprises a set of modular cells 10, including a first cell 10A comprising a set of profiles 100 including: a first structural profile 100A, having a first length L1 and enclosing a first volume V1 providing a first passageway P1; and a second profile 100B, having a second length L2 and enclosing a second volume V2, wherein the first passageway P1 is arranged to receive the second profile 100B therein.

Abstract: A packer for application to an aircraft airframe, the packer comprising: a sheet of material having a first surface and a second surface opposite to the first surface; and a plurality of voids defined through the sheet of material from the first surface to the second surface, thereby to provide that the sheet of material is flexible. The sheet of material may define a frame and a plurality of struts extending from one side of the frame to an opposite side of the frame. The frame and the struts may define, at least in part, the voids.

Abstract: The subject matter of this specification can be embodied in, among other things, a sensor that includes a first axial sensor housing portion having a first cross-sectional area, a second axial sensor housing portion arranged adjacent to the first axial sensor housing portion along the sensor axis and having a second cross-sectional area larger than the first cross-sectional area, and a face extending from the interior surface of the first axial sensor housing portion to the interior surface of the second axial sensor housing portion, a first buffer rod within the first axial sensor housing portion and having a first axial end and a second axial end, a second buffer rod within the second axial sensor housing portion and abutting the face, and having a third axial end and a fourth axial end, and an acoustic transceiver element acoustically mated to the second axial end and the third axial end.

Abstract: The subject matter of this specification can be embodied in, among other things, a position sensor system that includes a sensor housing defining a first cavity having a first face, a fluid effector including an actuator housing having an inner surface defining a second cavity, and a moveable body having a second face and configured for reciprocal movement within the second cavity, an acoustic transmitter system configured to emit a first emitted acoustic waveform toward the first face, and emit a second emitted acoustic waveform toward the second face, and an acoustic receiver system configured to detect a first reflected acoustic waveform based on a first reflection of the first emitted acoustic waveform based on the first face, and detect a second reflected acoustic waveform based on a second reflection of the second emitted acoustic waveform based on the second face.

Abstract: A method of producing at least part of a structural frame of a vehicle, the method comprising: providing a support structure (300), the support structure (300) comprising: a plurality of elongate members (301); and one or more retaining members (208) configured to retain the elongate members (301); mounting a plurality of first structural components (206) to the support structure (300) by coupling the first structural components (206) to the elongate members (301) such that each first structural component (206) occupies a different respective position along the elongate members (301); and attaching a plurality of second structural components (204) to the first structural components (206), thereby coupling together the first structural components (206) to form the at least part of the structural frame of a vehicle.

Abstract: The subject matter of this specification can be embodied in, among other things, a fluid flow measurement apparatus includes an inlet configured to flow a dynamic fluid flow, an outlet configured to flow the dynamic fluid flow, a first fluid conduit fluidically connected between the inlet and the outlet, configured with a first predetermined geometry, and configured to flow a first portion of the dynamic fluid flow, a second fluid conduit fluidically connected between the inlet and the outlet, configured with a second predetermined geometry, and configured to flow a second portion of the dynamic fluid flow, and a first flow meter configured to measure the second portion of the dynamic fluid flow.

Abstract: A plug assembly in which the insulator part can be moved from an unfolded state to a folded state. The insulator may be utilised in the unfolded state for assembly of a wiring loom and then folded into the folded state for insertion into a connector body.

Abstract: The subject matter of this specification can be embodied in, among other things, a fluid flow conditioning apparatus that includes a linear fluid conduit having a first tubular body defining a major axis and extending from a conduit inlet to a conduit outlet arranged opposite the conduit inlet, and configured with a predetermined flow geometry to define a linear fluid flow path along the major axis, a fluid inlet non-parallel to the linear fluid flow path, a first fluid flow conditioner configured to receive fluid flow, condition fluid flow, and redirect conditioned fluid flow along the linear fluid flow path along the major axis, a second fluid flow conditioner configured to receive fluid flow from the linear fluid flow path along the major axis, redirect fluid flow away from the linear fluid flow path, and condition fluid flow.