Abstract: The present invention provides topical dermal compositions including the compositions of the invention are useful for treating a variety of conditions associated with excess sebum production, such as, for example, acne.

Abstract: The present invention provides topical dermal compositions useful for treating a variety of conditions associated with excess sebum production, such as for example acne.

Abstract: Orally deliverable pharmaceutical compositions are provided comprising a drug of tow water solubility suspended in an aqueous liquid vehicle comprising a wetting agent, a thixotropic thickening agent, and an inorganic suspending agent. The compositions are thixotropic, substantially deflocculated, and substantially physically stable.

Abstract: The invention provides therapies for treating human papillomavirus.

Abstract: A pharmaceutical composition for application to an area of skin of a subject for local and/or systemic treatment of a COX-2 mediated disorder comprises a backing sheet that is flexibly conformable to the area of skin, the backing sheet having opposing surfaces that are respectively distal and proximal to the skin when applied; and a coating on the proximal surface of the backing sheet that comprises (a) an adhesive and (b) a water-soluble active agent selected from selective COX-2 inhibitory drugs, prodrugs and salts thereof, the active agent being in a therapeutically effective total amount and dispersed in a matrix that comprises zero to less than an active agent solubilizing effective amount in total of one or more solvents other than the adhesive.

Abstract: A pharmaceutical composition for application to an area of skin of a subject for local and/or systemic treatment of a COX-2 mediated disorder comprises a backing sheet that is flexibly conformable to the area of skin, the backing sheet having opposing surfaces that are respectively distal and proximal to the skin when applied; and a coating on the proximal surface of the backing sheet that comprises (a) an adhesive and (b) an active agent comprising valdecoxib or a prodrug thereof or a salt thereof, the active agent being in a therapeutically effective total amount and dispersed in a matrix that comprises zero to less than an active agent solubilizing effective amount in total of one or more solvents other than the adhesive.

Abstract: A dermally deliverable pharmaceutical composition comprises at least one selective cyclooxygenase-2 (COX-2) inhibitory drug or prodrug thereof solubilized in a pharmaceutically acceptable carrier that comprises a low molecular weight monohydric alcohol, and exhibits a skin permeation rate of the therapeutic agent at least equal to that exhibited by a reference solution of the therapeutic agent in 70% aqueous ethanol. A method of effecting targeted delivery of a selective COX-2 inhibitory drug to a site of pain and/or inflammation in a subject comprises topically administering such a composition to skin of the subject, preferably at a locus overlying or adjacent to the site of pain and/or inflammation. A method of effecting systemic treatment of a subject having a COX-2 mediated disorder comprises transdermally administering such a composition, preferably by contacting the composition with an area of skin of the subject not greater than about 400 cm2.

Abstract: A pharmaceutical composition suitable for oral administration is provided, the composition comprising an aqueous medium having suspended therein a solid substance of low water solubility in particulate form, and further comprising a suspending agent and at least one pharmaceutically acceptable water-soluble or swellable nonsurfactant polymer, the total amount of all such polymers present being ineffective to (a) increase viscosity of the composition to a degree that significantly impairs pourability, or (b) significantly increase rate of sedimentation or phase separation, of the composition. The composition has improved mouth feel.

Abstract: Orally deliverable pharmaceutical compositions are provided comprising a drug of low water solubility suspended in an aqueous liquid vehicle comprising a wetting agent, a thixotropic thickening agent, and an inorganic suspending agent. The compositions are thixotropic, substantially deflocculated, and substantially physically stable.