Abstract: Provided are tetrahydroisoquinoline derivatives, the preparation and use thereof. More specifically, provided are the tetrahydroisoquinoline derivatives or a pharmaceutically acceptable salt, ester, stereoisomer, tautomer, polymorph, solvate, isotopically labeled compound, metabolite or prodrug thereof. Further provided are a preparation process of the compound, the intermediates, a pharmaceutical composition comprising the compound and the use thereof in the treatment or prevention of a thromboembolic disorder.

Abstract: Provided are tetrahydroisoquinoline derivatives, the preparation and use thereof. More specifically, provided are the tetrahydroisoquinoline derivatives or a pharmaceutically acceptable salt, ester, stereoisomer, tautomer, polymorph, solvate, isotopically labeled compound, metabolite or prodrug thereof. Further provided are a preparation process of the compound, the intermediates, a pharmaceutical composition comprising the compound and the use thereof in the treatment or prevention of a thromboembolic disorder.

Abstract: A reverse rotary sprinkler drilling pipe system with anti-sticking function and its application method. This system comprises the front and rear drilling pipes which are arranged in sequence, a water spraying device, a rotary device. The rear drilling pipe is connected with an external drilling rig. The front and rear drilling pipes are respectively arranged with through holes in an inner axial direction. The water spraying device comprises a first cylinder and a connecting body, and symmetrical multiple groups of water spraying holes are arranged on the inner sidewall of the first cylinder. A limit block is arranged in the upper part of the inner sidewall. The connecting body is disposed with water conveyance hole which is connected with the through hole and the inner part of the first cylinder.

Abstract: A reverse rotary sprinkler drilling pipe system with anti-sticking function and its application method. This system comprises the front and rear drilling pipes which are arranged in sequence, a water spraying device, a rotary device. The rear drilling pipe is connected with an external drilling rig. The front and rear drilling pipes are respectively arranged with through holes in an inner axial direction. The water spraying device comprises a first cylinder and a connecting body, and symmetrical multiple groups of water spraying holes are arranged on the inner sidewall of the first cylinder. A limit block is arranged in the upper part of the inner sidewall. The connecting body is disposed with water conveyance hole which is connected with the through hole and the inner part of the first cylinder.

Abstract: In one general aspect, a control circuit for a power converter can include a feedback terminal configured to be coupled to a non-isolated feedback of the power converter when a feedback of the power converter is the non-isolated feedback, or configured to be coupled to a ground when the feedback of the power converter is an isolated feedback. The control circuit can include a detection circuit, coupled to the feedback terminal. The detection circuit can be configured to trigger a feedback voltage at the feedback terminal within an initial setting of the power converter. The feedback voltage can be high in response to the feedback terminal being coupled to the feedback of the power converter, and the feedback voltage can be low in response to the feedback terminal being coupled to the ground of the power converter.

Abstract: In a general aspect, a control circuit for a power converter can include an option selector circuit that is coupled with a detection pin. The option selector can, based on a voltage applied to the detection pin being greater than or less than a threshold voltage, respectively generate a first enable signal or generate a second enable signal. The control circuit can also include a first mode controller coupled with the option selector and the detection pin. The first mode controller can be configured to, in response to receiving the first enable signal, operate the power converter in a first mode of operation. The control circuit can further include a second mode controller coupled with the option selector and the detection pin. The second mode controller can being configured to, in response to receiving the second enable signal, operate the power converter in a second mode of operation.

Abstract: In a general aspect, a control circuit for a power converter can include an option selector circuit that is coupled with a detection pin. The option selector can, based on a voltage applied to the detection pin being greater than or less than a threshold voltage, respectively generate a first enable signal or generate a second enable signal. The control circuit can also include a first mode controller coupled with the option selector and the detection pin. The first mode controller can be configured to, in response to receiving the first enable signal, operate the power converter in a first mode of operation. The control circuit can further include a second mode controller coupled with the option selector and the detection pin. The second mode controller can being configured to, in response to receiving the second enable signal, operate the power converter in a second mode of operation.

Abstract: In one general aspect, a control circuit for a power converter can include a feedback terminal configured to be coupled to a non-isolated feedback of the power converter when a feedback of the power converter is the non-isolated feedback, or configured to be coupled to a ground when the feedback of the power converter is an isolated feedback. The control circuit can include a detection circuit, coupled to the feedback terminal. The detection circuit can be configured to trigger a feedback voltage at the feedback terminal within an initial setting of the power converter. The feedback voltage can be high in response to the feedback terminal being coupled to the feedback of the power converter, and the feedback voltage can be low in response to the feedback terminal being coupled to the ground of the power converter.

Abstract: A digital PFC circuit with improved power factor is described. The digital PFC circuit uses a compensation current generating unit and a reference current adjust unit to eliminate the effect of a current flowing through an input capacitor to the input current, so that the input current and the input line voltage of the digital PFC circuit are controlled to be in-phase.

Abstract: A PFC circuit having a switching circuit and a control circuit, the control circuit controls an operation mode of the switching circuit based on an input current and a switching frequency of the switching circuit, when the switching circuit works under a continuous current mode, the switching circuit is turned ON when the input current is less than an OFF current reference signal, and when the switching circuit works under a first discontinuous mode or a second discontinuous mode, the switching circuit is turned ON after a turn ON delay time period when the input current is less than the OFF current reference signal.

Abstract: A digital PFC circuit with improved power factor is described. The digital PFC circuit uses a compensation current generating unit and a reference current adjust unit to eliminate the effect of a current flowing through an input capacitor to the input current, so that the input current and the input line voltage of the digital PFC circuit are controlled to be in-phase.

Abstract: A PFC circuit having a switching circuit and a control circuit, the control circuit controls an operation mode of the switching circuit based on an input current and a switching frequency of the switching circuit, when the switching circuit works under a continuous current mode, the switching circuit is turned ON when the input current is less than an OFF current reference signal, and when the switching circuit works under a first discontinuous mode or a second discontinuous mode, the switching circuit is turned ON after a turn ON delay time period when the input current is less than the OFF current reference signal.

Abstract: A power supply includes a drive signal generator to generate a drive signal to control a switching of power switch. A feedback circuit is coupled to receive a feedback signal representative of the output to generate a control signal. An oscillator circuit is coupled to generate an oscillating signal in response to the control signal, from which the drive signal is generated in response. A frequency of the oscillating signal increases from a first frequency to a second frequency with respect to the control signal for a first range of control signal values, remains substantially equal to the second frequency for a second range of control signal values, and decreases from the second frequency to a third frequency with respect to the control signal for a third range of control signal values. The first range is less than the second range, which is less than the third range.

Abstract: This relates to sampling a feedback signal representative of an output of a power converter. The sampling is performed using a buffer sampling circuit having three sample and hold stages coupled in series to sense and store the feedback signal. The first stage is coupled to sample and hold the feedback signal on a capacitor. If the output diode is conducting, the sampled signal is transferred to the second stage. If the output diode is conducting, the first stage will sample the feedback signal and the sampled signal will be transferred to be sampled and held by the second stage. When the output diode stops conducting, the sampled voltage held by the second stage is transferred to the third stage. The third stage stores the sampled voltage on a capacitor. As such, the controller may sample the feedback signal near the end of the output diode conduction time.

Abstract: A power converter control circuit includes a ramp signal circuit, a blanking circuit, and a pulse driver circuit. The ramp signal circuit provides a ramp signal in response to a power converter feedback signal and an enable signal. The blanking circuit provides a blanking signal in response to the ramp signal and a clock signal. The blanking signal is provided when both the ramp signal is increasing in value and the enable signal indicates a light load operating condition. The pulse driver circuit provides a power switch control pulse in accordance with the clock signal and in the absence of the blanking signal.

Abstract: A timing circuit of a controller generates a clock signal having a switching period for use by a pulse width modulation (PWM) circuit to control a switch of a power supply. The switching period of the clock signal is based on a charging time plus a discharging time of a capacitor included in the timing circuit. A first current source charges the capacitor while the timing circuit is in a normal charging mode. A second current source charges the capacitor while the timing circuit is in an alternative charging mode that is when the on time of the switch exceeds a threshold time. The current provided by the second current source is less than the current provided by the first current source such that the switching period of the clock signal is increased in response to the timing circuit entering the alternative charging mode.

Abstract: This relates to sampling a feedback signal representative of an output of a power converter. The sampling is performed using a buffer sampling circuit having three sample and hold stages coupled in series to sense and store the feedback signal. The first stage is coupled to sample and hold the feedback signal on a capacitor. If the output diode is conducting, the sampled signal is transferred to the second stage. If the output diode is conducting, the first stage will sample the feedback signal and the sampled signal will be transferred to be sampled and held by the second stage. When the output diode stops conducting, the sampled voltage held by the second stage is transferred to the third stage. The third stage stores the sampled voltage on a capacitor. As such, the controller may sample the feedback signal near the end of the output diode conduction time.

Abstract: A timing circuit of a controller generates a clock signal having a switching period for use by a pulse width modulation (PWM) circuit to control a switch of a power supply. The switching period of the clock signal is based on a charging time plus a discharging time of a capacitor included in the timing circuit. A first current source charges the capacitor while the timing circuit is in a normal charging mode. A second current source charges the capacitor while the timing circuit is in an alternative charging mode that is when the on time of the switch exceeds a threshold time. The current provided by the second current source is less than the current provided by the first current source such that the switching period of the clock signal is increased in response to the timing circuit entering the alternative charging mode.

Abstract: A power converter control circuit includes a ramp signal circuit, a blanking circuit, and a pulse driver circuit. The ramp signal circuit provides a ramp signal in response to a power converter feedback signal and an enable signal. The blanking circuit provides a blanking signal in response to the ramp signal and a clock signal. The blanking signal is provided when both the ramp signal is increasing in value and the enable signal indicates a light load operating condition. The pulse driver circuit provides a power switch control pulse in accordance with the clock signal and in the absence of the blanking signal.

Abstract: A power converter controller is disclosed. An example controller includes a drive signal generator coupled to generate a drive signal to control a switching of a power switch to control a transfer of energy from an input of a power supply to an output of the power supply. A feedback circuit is coupled to receive a feedback signal representative of the output of the power supply. The feedback circuit coupled to generate a control signal in response to the feedback signal. An oscillator circuit is coupled to generate an oscillating signal in response to the control signal. The drive signal generator is coupled to generate the drive signal in response to the oscillating signal. A frequency of the oscillating signal increases from a first frequency to a second frequency with respect to the control signal for a first range of control signal values. The frequency of the oscillating signal remains substantially equal to the second frequency for a second range of control signal values.