Abstract: The present disclosure belongs to technical field of indoor positioning, and discloses a method and system for wide-area acoustic indoor positioning based on RF enhancement, comprising: design of an acoustic signal, using Blackman window function to control the amplitude of acoustic signal entering and leaving channel; a mixed multiple access transmission of the acoustic signal, combining three multiple access schemes of time, space and frequency, assisting a small amount of BLE signals, and constructing a wide-area coverage capability of the acoustic positioning signal; acoustic measurement based on RF enhancement, including TOA estimation of an acoustic signal and area identification based on low-power Bluetooth RSS; robust fusion positioning of an inertial sensor and multi-source measurement, including pedestrian walking speed estimation, multi-source heterogeneous measurement, acoustic measurement compensation and correction, measurement quality evaluation and control.