Patents by Inventor Guenter Eisbrenner

Guenter Eisbrenner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Optimizing temperature shifting in high cell density fermentations
    Publication number: 20030108997
    Abstract: The invention relates to a fermentation method for improving the expression of a heterologous protein in E. coli cells which requires a slow temperature shift downward during the expression phase, beginning at 35° C. with the temperature being lowered in small increments (from 0.2 to 0.8° C.) at 10 to 30 minutes intervals, until the temperature reaches 26° C. The temperature shift begins 20 to 60 minutes following induction of the expression phase.
    Type: Application
    Filed: September 17, 2002
    Publication date: June 12, 2003
    Inventors: Klaus Di. Mahr, Guenter Eisbrenner, Herbert Maerkl