Patents by Inventor Gui-Dong Zhu

Gui-Dong Zhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE
    Publication number: 20080269234
    Abstract: Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.
    Type: Application
    Filed: June 12, 2008
    Publication date: October 30, 2008
    Applicant: ABBOTT LABORATORIES
    Inventors: Virajkumar B. Gandhi, Vincent L. Giranda, Jianchun Gong, Thomas D. Penning, Gui-Dong Zhu
  • INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE
    Publication number: 20080161280
    Abstract: Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.
    Type: Application
    Filed: December 27, 2007
    Publication date: July 3, 2008
    Applicant: Abbott Laboratories
    Inventors: Virajkumar B. Gandhi, Vincent L. Giranda, Jianchun Gong, Thomas D. Penning, Gui-Dong Zhu
  • POLY(ADP-RIBOSE)POLYMERASE INHIBITORS
    Publication number: 20080108659
    Abstract: Compounds which inhibit the activity of poly(ADP-ribose)polymerase, compositions containing the compounds and methods of treating diseases using the compounds is disclosed.
    Type: Application
    Filed: October 4, 2007
    Publication date: May 8, 2008
    Inventors: Virajkumar Gandhi, Vincent Giranda, Thomas Penning, Gui-Dong Zhu
  • SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS
    Publication number: 20070270476
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
    Type: Application
    Filed: July 30, 2007
    Publication date: November 22, 2007
    Inventors: Thomas Penning, Sheela Thomas, Gui-Dong Zhu, Jianchun Gong, Vincent Giranda, Viraj Gandhi
  • SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS
    Publication number: 20070259937
    Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.
    Type: Application
    Filed: May 2, 2007
    Publication date: November 8, 2007
    Inventors: Vincent L. Giranda, Thomas D. Penning, Virajkamar B. Gandhi, Sheela A. Thomas, Gui-Dong Zhu, Jianchun Gong
  • PYRAZOLOQUINOLONES ARE POTENT PARP INHIBITORS
    Publication number: 20070249597
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
    Type: Application
    Filed: February 15, 2007
    Publication date: October 25, 2007
    Inventors: THOMAS PENNING, Gui-Dong Zhu, Virajkumar Gandhi, Jianchun Gong, Vincent Giranda
  • 1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS
    Publication number: 20070179136
    Abstract: Compound having formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds having formula (I), methods of treatment comprising compounds having formula (I), and methods of inhibiting the PARP enzyme comprising compounds having formula (I).
    Type: Application
    Filed: September 29, 2006
    Publication date: August 2, 2007
    Inventors: Thomas Penning, Sheela Thomas, Gui-Dong Zhu, Virajkumar Gandhi, Jianchun Gong, Vincent Giranda
  • SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS
    Publication number: 20070112047
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
    Type: Application
    Filed: November 15, 2006
    Publication date: May 17, 2007
    Inventors: Thomas Penning, Sheela Thomas, Gui-Dong Zhu, Jianchun Gong, Vincent Giranda, Viraj Gandhi
  • 2-Substituted-1 H-benzimidazile-4-carboxamides are PARP inhibitors
    Publication number: 20060229351
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), method of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compound of Formula (I).
    Type: Application
    Filed: April 11, 2006
    Publication date: October 12, 2006
    Inventors: Gui-Dong Zhu, Virajkumar Gandhi, Jianchun Gong, Thomas Penning, Vincent Giranda, Sheela Thomas
  • 1H-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent PARP inhibitors
    Publication number: 20060229289
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
    Type: Application
    Filed: April 11, 2006
    Publication date: October 12, 2006
    Inventors: Gui-Dong Zhu, Jianchun Gong, Virajkumar Gandhi, Thomas Penning, Vincent Giranda
  • Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
    Publication number: 20050250768
    Abstract: The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
    Type: Application
    Filed: August 20, 2004
    Publication date: November 10, 2005
    Inventors: James Link, Gang Liu, ZhongHua Pei, Tom Geldern, Martin Winn, Zhili Xin, Steven Boyd, Gui-Dong Zhu, Jennifer Freeman, Indrani Gunawardana, Michael Staeger, Hwan-Soo Jae, John Lynch, Sheldon Wang
  • Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
    Patent number: 6878700
    Abstract: The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immunune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
    Type: Grant
    Filed: March 31, 2000
    Date of Patent: April 12, 2005
    Assignee: Abbott Laboratories
    Inventors: James Link, Gang Liu, ZhongHua Pei, Tom von Geldern, Martin Winn, Zhili Xin, Steven A. Boyd, Gui-Dong Zhu, Jennifer C. Freeman, Indrani W. Gunawardana, Michael A. Staeger, Hwan-Soo Jae, John K. Lynch, Sheldon Wang
  • Kinase inhibitors
    Patent number: 6831175
    Abstract: Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.
    Type: Grant
    Filed: December 12, 2002
    Date of Patent: December 14, 2004
    Assignee: Abbott Laboratories
    Inventors: Qun Li, Keith W. Woods, Gui-Dong Zhu, John P. Fischer, Jianchun Gong, Tongmei Li, Virajkumar Gandhi, Sheela A. Thomas, Garrick K. Packard, Xiaohong Song, Jason N. Abrams, Robert B. Diebold, Jürgen Dinges, Charles W. Hutchins, Vincent S. Stoll, Saul H. Rosenberg, Vincent L. Giranda
  • Cell adhesion-inhibiting antiinflammatory compounds
    Publication number: 20030220365
    Abstract: Compounds having Formula I 1
    Type: Application
    Filed: March 12, 2003
    Publication date: November 27, 2003
    Inventors: Andrew O. Stewart, Steven A. Boyd, David L. Arendsen, Pramila Bhatia, Kevin R. Condroski, Jennifer C. Freeman, Indrani W. Gunawardana, Gui-Dong Zhu, Kraig Lartey, Catherine M. McCarty, Nicholas A. Mort, Meena V. Patel, Michael A. Staeger, David M. Stout
  • Kinase inhibitors
    Publication number: 20030199511
    Abstract: Compounds having the formula 1
    Type: Application
    Filed: December 12, 2002
    Publication date: October 23, 2003
    Inventors: Qun Li, Keith W. Woods, Gui-Dong Zhu, John P. Fischer, Jianchun Gong, Tongmei Li, Virajkumar Gandhi, Sheela A. Thomas, Garrick K. Packard, Xiaohong Song, Jason N. Abrams, Robert B. Diebold, Jurgen Dinges, Charles W. Hutchins, Vincent S. Stoll, Saul H. Rosenberg, Vincent L. Giranda
  • Kinase inhibitors
    Publication number: 20030187026
    Abstract: Compounds having the formula 1
    Type: Application
    Filed: November 18, 2002
    Publication date: October 2, 2003
    Inventors: Qun Li, Keith W. Woods, Gui-Dong Zhu, John P. Fischer, Jianchun Gong, Tongmei Li, Virajkumar Gandhi, Sheela A. Thomas, Garrick K. Packard, Xiaohong Song, Jason N. Abrams, Robert Diebold, Jurgen Dinges, Charles Hutchins, Vincent S. Stoll, Saul H. Rosenberg, Vincent L. Giranda
  • Cell adhesion-inhibiting antiinflammatory compounds
    Patent number: 6579882
    Abstract: Compounds having Formula I are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of inhibiting/treating inflammatory diseases in a mammal.
    Type: Grant
    Filed: March 6, 2001
    Date of Patent: June 17, 2003
    Assignee: Abbott Laboratories
    Inventors: Andrew O. Stewart, Steven A. Boyd, David L. Arendsen, Pramila Bhatia, Kevin R. Condroski, Jennifer C. Freeman, Indrani W. Gunawardana, Gui-Dong Zhu, Kraig Lartey, Catherine M. McCarty, Nicholas A. Mort, Meena V. Patel, Michael A. Staeger, David M. Stout
  • Cell adhesion-inhibiting antiinflammatory compounds
    Publication number: 20010020030
    Abstract: Compounds having Formula I 1
    Type: Application
    Filed: March 6, 2001
    Publication date: September 6, 2001
    Inventors: Andrew O. Stewart, Steven A. Boyd, David L. Arendsen, Pramila Bhatia, Kevin R. Condroski, Jennifer C. Freeman, Indrani W. Gunawardana, Gui-Dong Zhu, Kraig Lartey, Catherine M. McCarty, Nicholas A. Mort, Meena V. Patel, Michael A. Staeger, David M. Stout
  • Cell adhesion-inhibiting antiinflammatory compounds
    Patent number: 6232320
    Abstract: Compounds having Formula I are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of inhibiting/treating inflammatory diseases in a mammal.
    Type: Grant
    Filed: June 3, 1999
    Date of Patent: May 15, 2001
    Assignee: Abbott Laboratories
    Inventors: Andrew O. Stewart, Steven A. Boyd, David L. Arendsen, Pramila Bhatia, Kevin R. Condroski, Jennifer C. Freeman, Indrani W. Gunawardana, Gui-Dong Zhu, Kraig Lartey, Catherine M. McCarty, Nicholas A. Mort, Meena V. Patel, Michael A. Staeger, David M. Stout