Patents by Inventor Guido Marcucci

Guido Marcucci has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BORONIC ACID ESTERS AND PHARMACEUTICAL FORMULATIONS THEREOF
    Publication number: 20160347791
    Abstract: Provided herein are boronic acid esters of boronic acid therapeutic agents, such as bortezomib. The boronic acid esters can be used to prepare liposomal formulations of boronic acid therapeutic agents with improved properties, such as enhanced stability. This disclosure, in one aspect, relates to compositions and methods of making and using the compositions.
    Type: Application
    Filed: February 3, 2015
    Publication date: December 1, 2016
    Inventors: Michael Caligiuri, Robert Lee, Guido Marcucci
  • METHODS FOR SUPPRESSING CANCER-RELATED CACHEXIA
    Publication number: 20150150832
    Abstract: Methods of suppressing cachexia in a mammal with cancer comprising administering HDAC inhibitors are provided. Aspects include methods of administering an HDAC class 1 and 2b inhibitor in an amount effective to substantially maintain the mammal's weight compared to a mammal that does receive the HDAC class 1 and 2b inhibitor.
    Type: Application
    Filed: November 19, 2014
    Publication date: June 4, 2015
    Inventors: Ching-Shih Chen, Tanios Bekaii-Saab, Denis Guttridge, Guido Marcucci, Samuel Kulp, Yu-Chou Tseng
  • Therapeutic agents for the treatment of leukemia
    Patent number: 8633161
    Abstract: The invention provides for methods of treating a mammal who has a BCR/ABL-mediated leukemia, including chronic myelogenous leukemia (CML), particularly the blast crisis stage of CML, Philadelphia-positive acute lymphoblastic leukemia (Ph?-ALL), and refractory leukemias. The invention also provides for compounds for the treatment of these leukemias and methods of identifying anti-leukemic agents.
    Type: Grant
    Filed: March 24, 2006
    Date of Patent: January 21, 2014
    Assignee: The Ohio State University Research Foundation
    Inventors: Danilo Perrotti, Paolo Neviani, Ramasamy Santhanam, John C. Byrd, Guido Marcucci, Natarajan Muthusamy, Ching-Shih Chen
  • Hybridization Quantitation Method for Modified Micro-RNA and -DNA Based Oligonucleotides
    Publication number: 20110027798
    Abstract: Described herein is a method for the qualitative and/or quantitative determination of an analyte in a test sample which includes base pairing at least one oligonucleotide to a capture template having an overhang; and, hybridizing with a detection probe.
    Type: Application
    Filed: March 31, 2009
    Publication date: February 3, 2011
    Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Kenneth K. Chan, Zhongfa Liu, Zhiliang Xie, Guido Marcucci, John C. Byrd, Natarajan Muthusamy, Ramiro Garzon, Shujun Lui
  • THERAPEUTIC AGENTS FOR THE TREATMENT OF LEUKEMIA
    Publication number: 20100256072
    Abstract: The invention provides for methods of treating a mammal who has a BCR/ABL-mediated leukemia, including chronic myelogenous leukemia (CML), particularly the blast crisis stage of CML, Philadelphia-positive acute lymphoblastic leukemia (Ph?-ALL), and refractory leukemias. The invention also provides for compounds for the treatment of these leukemias and methods of identifying anti-leukemic agents.
    Type: Application
    Filed: March 24, 2006
    Publication date: October 7, 2010
    Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Danilo Perrotti, Paolo Neviani, Ramasamy Santhanam, John C. Byrd, Guido Marcucci, Natarajan Muthusamy, Ching-Shih Chen