Patents by Inventor Guifu Dai

Guifu Dai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Andrographolide derivatives and method of using the same for treatment or prevention of fibrosis
    Patent number: 11369584
    Abstract: A method of treatment or prevention of fibrosis of human tissue or organ. The method includes administering a patient in need thereof a compound of formula (I).
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: June 28, 2022
    Assignee: ZHENGZHOU UNIVERSITY
    Inventors: Guifu Dai, Haiwei Xu, Zhenzhen Guan, Yake Wang, Di Wu, Pengpeng Shen, Ning Shang, Fengjuan Wu, Jin Zhao, Xiaopei Zhang
  • Andrographolide compound and method for treatment or prevention of fibrotic disease using the same
    Patent number: 11279695
    Abstract: A compound represented by formula I or II.
    Type: Grant
    Filed: September 2, 2020
    Date of Patent: March 22, 2022
    Assignee: ZHENGZHOU UNIVERSITY
    Inventors: Guifu Dai, Di Wu, Haiwei Xu, Jiazhen Zhu, Zibo Fu, Zhenzhen Guan, Xiaopei Zhang, Ning Shang, Shuqiu Zhang, Guangming Yan
  • ANDROGRAPHOLIDE COMPOUND AND METHOD FOR TREATMENT OR PREVENTION OF FIBROTIC DISEASE USING THE SAME
    Publication number: 20210047307
    Abstract: A compound represented by formula I or II.
    Type: Application
    Filed: September 2, 2020
    Publication date: February 18, 2021
    Inventors: Guifu DAI, Di WU, Haiwei XU, Jiazhen ZHU, Zibo FU, Zhenzhen GUAN, Xiaopei ZHANG, Ning SHANG, Shuqiu ZHANG, Guangming YAN
  • ANDROGRAPHOLIDE DERIVATIVES AND METHOD OF USING THE SAME FOR TREATMENT OR PREVENTION OF FIBROSIS
    Publication number: 20200030280
    Abstract: A method of treatment or prevention of fibrosis of human tissue or organ. The method includes administering a patient in need thereof a compound of formula (I).
    Type: Application
    Filed: September 30, 2019
    Publication date: January 30, 2020
    Inventors: Guifu DAI, Haiwei XU, Zhenzhen GUAN, Yake WANG, Di WU, Pengpeng SHEN, Ning SHANG, Fengjuan WU, Jin ZHAO, Xiaopei ZHANG
  • Use of 15-benzylidence-14-deoxy-11, 12 -dehyroandrographolide derivative in manufacture of medicaments for protecting liver and anti-hepatitis C virus
    Patent number: 9636324
    Abstract: Disclosed is use of andrographolide derivative as shown by general formula 1 in manufacture of medicaments for anti-hepatitis C virus, and preventing and treating immunological liver damage caused by virus infection and different chemical liver damage.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: May 2, 2017
    Assignee: Zhengzhou University
    Inventors: Guifu Dai, Jing Zhao, Haiwei Xu, Huanfei Liu, Zhenwei Wu, Di Wu, Jian Wu, Hongmin Liu
  • Use of 15-benzylidence-14-deoxy-11, 12 -dehyroandrographolide derivative in manufacture of medicaments for protecting liver and anti-hepatitis C virus
    Publication number: 20160279096
    Abstract: Disclosed is use of andrographolide derivative as shown by general formula 1 in manufacture of medicaments for anti-hepatitis C virus, and preventing and treating immunological liver damage caused by virus infection and different chemical liver damage.
    Type: Application
    Filed: June 8, 2016
    Publication date: September 29, 2016
    Inventors: Guifu Dai, Jing Zhao, Haiwei Xu, Huanfei Liu, Zhenwei Wu, Di Wu, Jian Wu, Hongmin Liu
  • Use of 15-benzylidene-14-deoxy-11, 12-dehydroandrographolide derivative in manufacture of medicaments for protecting liver and anti-hepatitis C virus
    Patent number: 9388169
    Abstract: Disclosed is use of andrographolide derivative as shown by general formula 1 in manufacture of medicaments for anti-hepatitis C virus, and preventing and treating immunological liver damage caused by virus infection and different chemical liver damage.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: July 12, 2016
    Assignee: Zhengzho University
    Inventors: Guifu Dai, Songlin Zhu, Yanan Wang, Jian Wu, Dan Zhao, Di Wu, Huanfei Liu, Haiwei Xu, Mengjiao Liu, Jing Zhao, Wei Han, Zhenwei Wu, Hang Wang, Hongmin Liu
  • Uses of 15-benzylidene-14-deoxy-11,12-didehydroandrographolide derivatives in the preparation of antineoplastic drugs
    Patent number: 9198894
    Abstract: The present invention relates to the preparation of anti-tumor drugs with andrographolide derivatives, which belongs to the field of pharmaceutical technology, and involves 15-benzylidene substituted derivatives of 14-deoxy-11,12-didehydro-andrographolide and their 3,19-ester derivatives. Proved by the experiments, these compounds significantly inhibited the colony formation and migration ability of various cancer cells, and also inhibited the migration ability of vascular endothelial cells in vitro. The compounds of this invention significantly inhibited the tumor growth, invasion, metastasis and angiogenesis on mouse xenograft models, and inhibited the experimental lung metastasis of B16-F10 malignant melanoma cells. Therefore, this class of compounds could be used as the active ingredients for the preparation of antineoplastic drugs, which are of efficiency and low-toxicity.
    Type: Grant
    Filed: October 19, 2011
    Date of Patent: December 1, 2015
    Assignee: Zhengzhou University
    Inventors: Fengjuan Wu, Guifu Dai, Haiwei Xu, Zhiwen Jiang, Liping Zhu, Lijun Yan, Hongmin Liu, Yanan Wang, Weiyi Li, Ruijing Dong
  • Use of 15-benzylidene-14-deoxy-11, 12-dehydroandrographolide derivative in manufacture of medicaments for protecting liver and anti-hepatitis C virus
    Publication number: 20150051403
    Abstract: Disclosed is use of andrographolide derivative as shown by general formula 1 in manufacture of medicaments for anti-hepatitis C virus, and preventing and treating immunological liver damage caused by virus infection and different chemical liver damage.
    Type: Application
    Filed: February 5, 2013
    Publication date: February 19, 2015
    Applicant: ZHENGZHOU UNIVERSITY
    Inventors: Guifu Dai, Songlin Zhu, Yanan Wang, Jian Wu, Dan Zhao, Di Wu, Huanfei Liu, Haiwei Xu, Mengjiao Liu, Jing Zhao, Wei Han, Zhenwei Wu, Hang Wang, Hongmin Liu
  • USES OF C15-SUBSTITUTED ANDROGRAPHOLIDE DERIVATIVES IN THE PREPARATION OF ANTI-HEPATITIS B VIRUS MEDICAMENT
    Publication number: 20140187627
    Abstract: Disclosed is a use of C15-substituted andrographolide derivatives in preparation of anti-hepatitis B virus medicaments. In the present invention, the HepG2.2.15 cells are used to measure the amount of the hepatitis B virus surface antigen (HBsAg) secretion in the supernatant of the culture; the duck hepatitis B virus (DHBV) is used to infect the model and the DHBV-DNA level in serum is measured, and the pathological change in hepatic tissue is observed. A number of andrographolide derivative compounds are screened, compounds having a good anti-HBV effect are preferred, which has a structure represented by general formula 1 set forth herein. Due to high anti-HBV activity and low toxicity, as well as good protection against hepatic injury, the compounds can be used as the active ingredient for preparing anti-HBV medicaments, thereby providing a new pharmaceutical way for treatment of hepatitis, and broadening the range of clinical medicines.
    Type: Application
    Filed: July 3, 2012
    Publication date: July 3, 2014
    Applicant: ZHENGZHOU UNIVERSITY
    Inventors: Guifu DAI, Haiwei XU, Zhiwen JIANG, Hongmin LIU, Yanan WANG, Kuicheng ZHU, Zhenwei WU, Weiyi LI, Fengjuan WU, Mengjiao LIU, Wei HAN
  • Uses of 15-benzylidene-14-deoxy-11,12-didehydroandrographolide Derivatives in the Preparation of Antineoplastic Drugs
    Publication number: 20130237596
    Abstract: The present invention relates to the preparation of anti-tumor drugs with andrographolide derivatives, which belongs to the field of pharmaceutical technology, and involves 15-benzylidene substituted derivatives of 14-deoxy-11,12-didehydro-andrographolide and their 3,19-ester derivatives. Proved by the experiments, these compounds significantly inhibited the colony formation and migration ability of various cancer cells, and also inhibited the migration ability of vascular endothelial cells in vitro. The compounds of this invention significantly inhibited the tumor growth, invasion, metastasis and angiogenesis on mouse xenograft models, and inhibited the experimental lung metastasis of B16-F10 malignant melanoma cells. Therefore, this class of compounds could be used as the active ingredients for the preparation of antineoplastic drugs, which are of efficiency and low-toxicity.
    Type: Application
    Filed: October 19, 2011
    Publication date: September 12, 2013
    Applicant: ZHENGZHOU UNIVERSITY
    Inventors: Guifu Dai, Haiwei Xu, Liping Zhu, Ruijing Dong, Fengjuan Wu, Yanan Wang, Zhiwen Jiang, Lijun Yan, Weiyi Li, Hongmin Liu