Abstract: Described herein are molded dehydrated placental tissue compositions, and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the molded dehydrated placental tissue compositions are also described herein.

Abstract: Described herein are molded dehydrated placental tissue compositions, and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the molded dehydrated placental tissue compositions are also described herein.

Abstract: Described herein are molded dehydrated placental tissue compositions, and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the molded dehydrated placental tissue compositions are also described herein.

Abstract: Described herein are compositions and methods of using modified placental tissue to achieve endogenous and exogenous therapeutic effects. When applied to an injured or diseased organ or body part, the modified placental tissue elicit stem cell recruitment and/or localization directly to or proximate to the site of application. Also described is a novel vacuum drying device and the use thereof.

Abstract: Described herein are compositions and methods of using modified placental tissue to achieve endogenous and exogenous therapeutic effects. When applied to an injured or diseased organ or body part, the modified placental tissue elicit stem cell recruitment and/or localization directly to or proximate to the site of application. Also described is a novel vacuum drying device and the use thereof.

Abstract: Described herein are compositions and methods of using modified placental tissue to achieve endogenous and exogenous therapeutic effects. When applied to an injured or diseased organ or body part, the modified placental tissue elicit stem cell recruitment and/or localization directly to or proximate to the site of application. Also described is a novel vacuum drying device and the use thereof.

Abstract: Spinal disc and other implants include at least one flexible keel that extends substantially outwardly, typically upwardly or downwardly, beyond the primary body of the implant. Methods of fabricating elastomeric implants using a mold are also described.

Abstract: Methods for forming molded orthopedic implants with at least one mesh substrate having opposing upper and lower primary surfaces. At least a major portion of the mesh substrate lower primary surface is integrally moldably attached to the molded implant body. The methods are carried out so that the mesh substrate has at least one selectively exposed region devoid of molded material that exposes at least a portion of the mesh substrate upper surface to at least a partial thickness of the mesh substrate so as to allow for tissue in-growth in the at least one exposed region of the mesh substrate.

Abstract: Methods and systems for generating custom implants by programmatically analyzing a patient's image data to electronically obtain shapes and dimensions of relevant anatomical features of a target region of the patient; and fabricating a patient-specific replacement implant for the patient using the analyzed patient image data. Related patient-specific spinal implants are also described.

Abstract: Non-articulating semi-rigid spinal implants include upper and lower rigid endplates that define at least one aligned pair of rigid male and female members. The respective female member having an interior facing cavity and the respective male member facing toward the female cavity. At least one elastic member resides in each female member cavity. The device can include an optional housing with at least one bore for each of the at least one aligned pairs of female and male members. The housing bore is sized and configured to snugly encase each respective aligned pair of endplate male and female members while leaving an upper outer surface of the upper endplate and a lower outer surface of the lower endplate exposed.

Abstract: Trials for spinal surgery include: (a) a trial implant portion having a shape corresponding to an implantable spinal disc implant; (b) a shaft connected to the trial implant portion; and (c) at least one axially extending cutting guide slot attached to the shaft at a position that is axially spaced apart from the trial implant portion, the cutting guide slot configured to releasably slidably receive and guide a cutting blade toward vertebral bone. Also described are additional surgical instruments, including, for example, pilot-hole punches, inserters, and methods of cutting keelways.

Abstract: Methods of fabricating elastomeric implants employ a mold with PVA crystals and irrigant added to the mold independent of each other. Related molds are also described.

Abstract: Methods of fabricating elastomeric implants employ a mold with PVA crystals and irrigant added to the mold independent of each other. Related molds are also described.

Abstract: Methods for forming molded orthopaedic implants with at least one mesh substrate having opposing upper and lower primary surfaces. At least a major portion of the mesh substrate lower primary surface is integrally moldably attached to the molded implant body. The methods are carried out so that the mesh substrate has at least one selectively exposed region devoid of molded material that exposes at least a portion of the mesh substrate upper surface to at least a partial thickness of the mesh substrate so as to allow for tissue in-growth in the at least one exposed region of the mesh substrate.

Abstract: Molded orthopaedic implants include at least one mesh substrate having opposing upper and lower primary surfaces. At least a major portion of the mesh substrate lower primary surface is integrally moldably attached to the molded implant body. The mesh substrate has at least one selectively exposed region devoid of molded material that exposes at least a portion of the mesh substrate upper surface to at least a partial thickness of the mesh substrate so as to allow for tissue in-growth in the at least one exposed region of the mesh substrate.

Abstract: Non-articulating semi-rigid spinal implants include upper and lower rigid endplates that define at least one aligned pair of rigid male and female members. The respective female member having an interior facing cavity and the respective male member facing toward the female cavity. At least one elastic member resides in each female member cavity. The device can include an optional housing with at least one bore for each of the at least one aligned pairs of female and male members. The housing bore is sized and configured to snugly encase each respective aligned pair of endplate male and female members while leaving an upper outer surface of the upper endplate and a lower outer surface of the lower endplate exposed.

Abstract: Trials for spinal surgery include: (a) a trial implant portion having a shape corresponding to an implantable spinal disc implant; (b) a shaft connected to the trial implant portion; and (c) at least one axially extending cutting guide slot attached to the shaft at a position that is axially spaced apart from the trial implant portion, the cutting guide slot configured to releasably slidably receive and guide a cutting blade toward vertebral bone. Also described are additional surgical instruments, including, for example, pilot-hole punches, inserters, and methods of cutting keelways.

Abstract: Molded orthopaedic implants include at least one mesh substrate having opposing upper and lower primary surfaces. At least a major portion of the mesh substrate lower primary surface is integrally moldably attached to the molded implant body. The mesh substrate has at least one selectively exposed region devoid of molded material that exposes at least a portion of the mesh substrate upper surface to at least a partial thickness of the mesh substrate so as to allow for tissue in-growth in the at least one exposed region of the mesh substrate.

Abstract: Spinal implant devices include: (a) a spinal implant; and (b) at least on suture extending through a bone tunnel and attached to the spinal implant to fixate the spinal implant in the body.

Abstract: Methods and systems for generating custom implants by programmatically analyzing a patient's image data to electronically obtain shapes and dimensions of relevant anatomical features of a target region of the patient; and fabricating a patient-specific replacement implant for the patient using the analyzed patient image data. Related patient-specific spinal implants are also described.