Patent number: 6350757
Abstract: A compound selected from those of formula (I):
wherein:
represents single or double bond,
R1 represents hydrogen, alkyl, —R6-aryl, —R6-cycloalkyl, —R6-heterocycle, —CO2R7—, —COR8, or —CONHR8, wherein R6, R7, and R8 are as defined in the description,
R2 represents cyano, mono- or di-alkylaminoalkylaminocarbonyl, —CO2R8, —CONHR8, —NR8R9, —NHCO2R7, or —COR8 wherein R7, R8, and R9 are as defined in the description,
R3 and R4 together form (C3-C10)cycloalkyl,
R5 represents hydrogen, alkyl, or arylalkyl,
Ra, Rb, Rc, Rd, which may be identical or different, represent a group as defined in the description,
its isomers, and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful in the treatment of CNS disorders.
Type:
Grant
Filed:
July 21, 2000
Date of Patent:
February 26, 2002
Assignee:
Les Laboratoires Servier
Inventors:
Solo Goldstein, Guillaume Poissonnet, Jean-Gilles Parmentier, Jean-Daniel Brion, Mark Millan, Anne Dekeyne, Jean Boutin
Patent number: 5877190
Abstract: A compound of formula (I): ##STR1## wherein: R.sub.1 represents unsubstituted or substituted cycloalkyl, phenyl, naphthyl, heterocyclic, alkyl or alkenyl,A represents a bond, oxygen, sulphur, a group ##STR2## a group ##STR3## or a group ##STR4## wherein Rc represents hydrogen, alkyl or cycloalkyl, R.sub.2 represents halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, cycloalkyl, formyl, carboxy, alkylcarbonyl, cycloalkylcarbonyl, alkoxycarbonyl, cycloalkyloxycarbonyl, optionally substituted carbamoyl, optionally substituted amino, formylamino, cyano, optionally substituted amidino, hydroxyaminomethyl, amide oxime, hydrazono, or a group selected from: ##STR5## wherein R.sub.21, R.sub.22 and R.sub.23 are as defined in the description, R.sub.
Type:
Grant
Filed:
October 3, 1997
Date of Patent:
March 2, 1999
Assignee:
Adir et Compagnie
Inventors:
Alain Dhainaut, Guillaume Poissonnet, Emmanuel Canft, Michel Lonchampt