Patents by Inventor Guiren Wang
Guiren Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230288239Abstract: The present disclosure provides methods and systems for flight velocimetry employing at least one bleaching laser, at least one detection laser, at least one dichroic mirror, an objective, a detection system, and a nano stage to bleach a dye to form a bleached blot in a flow pathway.Type: ApplicationFiled: May 18, 2023Publication date: September 14, 2023Applicant: University of South CarolinaInventor: Guiren Wang
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Patent number: 11674834Abstract: The present disclosure provides methods and systems for flight velocimetry employing at least one bleaching laser, at least one detection laser, at least one dichroic mirror, an objective, a detection system, and a nano stage to bleach a dye to form a bleached blot in a flow pathway.Type: GrantFiled: September 3, 2019Date of Patent: June 13, 2023Assignee: University of South CarolinaInventor: Guiren Wang
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Publication number: 20200132528Abstract: The present disclosure provides methods and systems for successfully and accurately measuring the flow velocity, velocity fluctuation and velocity profile of flows of fluids with unprecedented resolution.Type: ApplicationFiled: September 3, 2019Publication date: April 30, 2020Applicant: University of South CarolinaInventor: Guiren Wang
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Patent number: 9878090Abstract: A micropump that pumps liquid using electrothermally-induced flow is described, along with a corresponding self-regulating pump and infusion pump. The micropump has applications in microfluidic systems, such as biochips. The self-regulating infusion pump is useful for administration of large and small volumes of liquids such as drugs to patients and can be designed for a wide range of flow rates by combining multiple micropumps in one infusion pump system. The micropump uses electrode sequences on opposing surfaces of a flow chamber that are staggered with respect to each other. The opposing surfaces include staggered electrodes that have the same phase and same electrode sequence. As such electrodes with the same phase are staggered and not eclipsed.Type: GrantFiled: December 16, 2015Date of Patent: January 30, 2018Assignee: CFD Research CorporationInventors: Sivaramakrishnan Krishnamoorthy, Guiren Wang, Jianjun Feng, Yi Wang
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Publication number: 20160235912Abstract: A micropump that pumps liquid using electrothermally-induced flow is described, along with a corresponding self-regulating pump and infusion pump. The micropump has applications in microfluidic systems, such as biochips. The self-regulating infusion pump is useful for administration of large and small volumes of liquids such as drugs to patients and can be designed for a wide range of flow rates by combining multiple micropumps in one infusion pump system. The micropump uses electrode sequences on opposing surfaces of a flow chamber that are staggered with respect to each other. The opposing surfaces include staggered electrodes that have the same phase and same electrode sequence. As such electrodes with the same phase are staggered and not eclipsed.Type: ApplicationFiled: December 16, 2015Publication date: August 18, 2016Inventors: Sivaramakrishnan Krishnamoorthy, Guiren Wang, Jianjun Feng, Yi Wang
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Patent number: 9283597Abstract: A micropump that pumps liquid using electrothermally-induced flow is described, along with a corresponding self-regulating pump and infusion pump. The micropump has applications in microfluidic systems such as biochips. The self-regulating infusion pump is useful for the administration of large and small volumes of liquids such as drugs to patients and can be designed for a wide range of flow rates by combining multiple micropumps in one infusion pump system.Type: GrantFiled: September 6, 2006Date of Patent: March 15, 2016Assignee: CFD Research CorporationInventors: Sivaramakrishnan Krishnamoorthy, Guiren Wang, Jianjun Feng, Yi Wang
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Patent number: 7998328Abstract: Methods and apparatus for the micro-scale, dielectrophoretic separation of particles are provided. Fluid suspensions of particles are sorted and separated by dielectrophoretic separation chambers that have at least two consecutive, electrically coupled planar electrodes separated by a gap in a fluid flow channel. The gap distance as well as applied potential can be used to control the dielectrophoretic forces generated. Using consecutive, electrically coupled electrodes rather than electrically coupled opposing electrodes facilitates higher flow volumes and rates. The methods and apparatus can be used, for example, to sort living, damaged, diseased, and/or dead cells and functionalized or ligand-bound polymer beads for subsequent identification and/or analysis.Type: GrantFiled: June 27, 2005Date of Patent: August 16, 2011Assignee: CFD Research CorporationInventors: Jianjun Feng, Guiren Wang, Sivaramakrishnan Krishnamoorthy, Kapil Pant, Shivshankar Sundaram
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Patent number: 7842006Abstract: The present invention is an ultrasonic thrombectomy catheter that produces physical forces (shear rates) strong enough to emulsify obstructions such as thrombi and emboli without causing damage to arterial walls. This is accomplished by properly arranging piezoelectric transducers within a catheter and a tubular catheter head separated by a gap to generate acoustic streaming that simultaneously emulsifies the obstruction and sweeps resulting debris into a catheter lumen for removal. The open gap may be formed by supporting struts that connect the catheter to the catheter head. The design of the catheter tip allows the fabrication of catheters capable of removing partial or complete blockages from arteries and other vessels having diameters as small as 2 mm.Type: GrantFiled: November 17, 2006Date of Patent: November 30, 2010Assignee: CFD Research CorporationInventors: Guiren Wang, Shivshankar Sundaram, Kapil Pant, Jianjun Feng, Peter Storm
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Patent number: 7428848Abstract: The present invention is an electrostatic collector for low cost, high throughput, high efficiency sampling and concentration of bioaerosols. The device is small enough to be portable and can be contained within or placed on the wall of a typical office or hospital building. The collector comprises one or more collector modules, each having an ionizing electrode, a conical outer electrode, a wet collection electrode, and a liquid collection system. Airflow through a collector module may be partially blocked to enhance the collection of smaller particles and the collection electrode may comprise multiple, programmable electrodes to focus particle deposition onto a smaller area. Particles are collected into a small volume of liquid to facilitate subsequent analysis by an attached analyzer or at a remote site.Type: GrantFiled: August 9, 2005Date of Patent: September 30, 2008Assignee: CFD Research CorporationInventors: Kapil Pant, Guiren Wang, Jianjun Feng, Shankar Sundaram
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Publication number: 20080119780Abstract: The present invention is an ultrasonic thrombectomy catheter that produces physical forces (shear rates) strong enough to emulsify obstructions such as thrombi and emboli without causing damage to arterial walls. This is accomplished by properly arranging piezoelectric transducers within a catheter and a tubular catheter head separated by a gap to generate acoustic streaming that simultaneously emulsifies the obstruction and sweeps resulting debris into a catheter lumen for removal. The open gap may be formed by supporting struts that connect the catheter to the catheter head. The design of the catheter tip allows the fabrication of catheters capable of removing partial or complete blockages from arteries and other vessels having diameters as small as 2 mm.Type: ApplicationFiled: November 17, 2006Publication date: May 22, 2008Applicant: CFD Research CorporationInventors: Guiren Wang, Shivshankar Sundaram, Kapil Pant, Jianjun Feng, Peter Storm
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Patent number: 7283215Abstract: Methods and apparatus for fluid flow velocity and flow rate measurement are provided. Fluid velocity is measured in optical method based on fluorescence photobleaching of a fluorescent dye. The invented method and apparatus requires a calibration relation between flow velocity and fluorescence signal and is easy to use. The invented method and apparatus can measure bulk flow velocity and flow rate inline, two and three components of flow velocity vector. It can also measure flow velocity in near wall region using evanescent wave. Since the invented method and apparatus uses molecular dye and calibration relation between flow velocity and fluorescence signal, it has ultra high spatial and temporal resolution. The invented method can be used not only to apparatuses and devices in conventional size, but also to that in MEMS and NEMS.Type: GrantFiled: March 3, 2006Date of Patent: October 16, 2007Inventors: Guiren Wang, Hong Jiang
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Publication number: 20070206179Abstract: Methods and apparatus for fluid flow velocity and flow rate measurement are provided. Fluid velocity is measured in optical method based on fluorescence photobleaching of a fluorescent dye. The invented method and apparatus requires a calibration relation between flow velocity and fluorescence signal and is easy to use. The invented method and apparatus can measure bulk flow velocity and flow rate inline, two and three components of flow velocity vector. It can also measure flow velocity in near wall region using evanescent wave. Since the invented method and apparatus uses molecular dye and calibration relation between flow velocity and fluorescence signal, it has ultra high spatial and temporal resolution. The invented method can be used not only to apparatuses and devices in conventional size, but also to that in MEMS and NEMS.Type: ApplicationFiled: March 3, 2006Publication date: September 6, 2007Inventors: Guiren Wang, Hong Jiang
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Publication number: 20070110625Abstract: A micropump that pumps liquid using electrothermally-induced flow is described, along with a corresponding self-regulating pump and infusion pump. The micropump has applications in microfluidic systems such as biochips. The self-regulating infusion pump is useful for the administration of large and small volumes of liquids such as drugs to patients and can be designed for a wide range of flow rates by combining multiple micropumps in one infusion pump system.Type: ApplicationFiled: September 6, 2006Publication date: May 17, 2007Inventors: Sivaramakrishnan Krishnamoorthy, Guiren Wang, Jianjun Feng, Yi Wang
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Publication number: 20070034025Abstract: The present invention is an electrostatic collector for low cost, high throughput, high efficiency sampling and concentration of bioaerosols. The device is small enough to be portable and can be contained within or placed on the wall of a typical office or hospital building. The collector comprises one or more collector modules, each having an ionizing electrode, a conical outer electrode, a wet collection electrode, and a liquid collection system. Airflow through a collector module may be partially blocked to enhance the collection of smaller particles and the collection electrode may comprise multiple, programmable electrodes to focus particle deposition onto a smaller area. Particles are collected into a small volume of liquid to facilitate subsequent analysis by an attached analyzer or at a remote site.Type: ApplicationFiled: August 9, 2005Publication date: February 15, 2007Inventors: Kapil Pant, Guiren Wang, Jianjun Feng, Shankar Sundaram
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Publication number: 20060290745Abstract: Methods and apparatus for the micro-scale, dielectrophoretic separation of particles are provided. Fluid suspensions of particles are sorted and separated by dielectrophoretic separation chambers that have at least two consecutive, electrically coupled planar electrodes separated by a gap in a fluid flow channel. The gap distance as well as applied potential can be used to control the dielectrophoretic forces generated. Using consecutive, electrically coupled electrodes rather than electrically coupled opposing electrodes facilitates higher flow volumes and rates. The methods and apparatus can be used, for example, to sort living, damaged, diseased, and/or dead cells and functionalized or ligand-bound polymer beads for subsequent identification and/or analysis.Type: ApplicationFiled: June 27, 2005Publication date: December 28, 2006Inventors: Jianjun Feng, Guiren Wang, Sivaramakrishnan Krishnamoorthy, Kapil Pant, Shivshankar Sundaram
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Publication number: 20020036949Abstract: An apparatus and process for the mixing of two or more fluid streams and creating streamwise vortices. The apparatus comprises of a chamber having a proximal end, a distal end, a corresponding frequency means for forcing the mixing of the two or more fluid streams, an inlet means for receiving the two or more fluid streams at the proximal end and a divider means for separating the two or more fluid streams mounted within the chamber at the proximal end.Type: ApplicationFiled: April 1, 1999Publication date: March 28, 2002Inventors: HEINRICH E FIEDLER, GUIREN WANG