Patents by Inventor Gui-Rong Li

Gui-Rong Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Water-soluble derivatives and prodrugs of acacetin and methods of making and using thereof
    Patent number: 9260461
    Abstract: Water-soluble derivatives and/or prodrugs of acacetin are described herein. The compounds can be used as cardioprotection agents against myocardial infarction induced by ischemia-reperfusion. In one embodiment the compounds are used to treat ischemic cardiac diseases. In the preferred embodiment, the compounds are used to treat and/or prevent myocardial infarction in humans.
    Type: Grant
    Filed: February 3, 2014
    Date of Patent: February 16, 2016
    Assignee: Versitech Limited
    Inventors: Gui-Rong Li, Feng Lin
  • Water-Soluble Derivatives and Prodrugs of Acacetin and Methods of Making and Using Thereof
    Publication number: 20150218193
    Abstract: Water-soluble derivatives and/or prodrugs of acacetin are described herein. The compounds can be used as cardioprotection agents against myocardial infarction induced by ischemia-reperfusion. In one embodiment the compounds are used to treat ischemic cardiac diseases. In the preferred embodiment, the compounds are used to treat and/or prevent myocardial infarction in humans.
    Type: Application
    Filed: February 3, 2014
    Publication date: August 6, 2015
    Applicants: Shanghai Institute of Pharmaceutical Industry, Versitech Limited
    Inventors: Gui-Rong Li, Feng Lin
  • Use of acacetin and related compounds as potassium channel inhibitors
    Patent number: 8461198
    Abstract: This invention provides a method for treating or preventing human atrial arrhythmia (fibrillation) using the leading flavone compound acacetin, and its derivatives and analogues that inhibit the ultra-rapidly-activating delayed rectifier potassium current (IKur or IKsus), transient outward potassium (Ito), and acetylcholine-activated potassium current (IK.Ach).
    Type: Grant
    Filed: September 7, 2010
    Date of Patent: June 11, 2013
    Assignees: Versitech Limited, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    Inventors: Gui-Rong Li, Chu-Pak Lau, Guo-Wei Qin, Hong-Bing Wang
  • Use of Acacetin and Related Compounds as Potassium Channel Inhibitors
    Publication number: 20100331271
    Abstract: This invention provides a method for treating or preventing human atrial arrhythmia (fibrillation) using the leading flavone compound acacetin, and its derivatives and analogues that inhibit the ultra-rapidly-activating delayed rectifier potassium current (IKur or IKsus), transient outward potassium (Ito), and acetylcholine-activated potassium current (IK.ACh).
    Type: Application
    Filed: September 7, 2010
    Publication date: December 30, 2010
    Inventors: Gui-Rong LI, Chu-Pak Lau, Guo-Wei Qin, Hong-Bing Wang
  • Use of acacetin and related compounds as potassium channel inhibitors
    Patent number: 7816400
    Abstract: This invention provides a method for treating or preventing human atrial arrhythmia (fibrillation) using the leading flavone compound acacetin, and its derivatives and analogues that inhibit the ultra-rapidly-activating delayed rectifier potassium current (IKur or IKsus), transient outward potassium (Ito), and acetylcholine-activated potassium current (IK.ACh).
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: October 19, 2010
    Assignees: The University of Hong Kong, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    Inventors: Gui-Rong Li, Chu-Pak Lau, Guo-Wei Qin, Hong-Bing Wang
  • Use of Flavone Compounds as Potassium Channel Inhibitors
    Publication number: 20080214493
    Abstract: This invention provides a method for treating or preventing human atrial arrhythmia (fibrillation) using the leading flavone compound acacetin, and its derivatives and analogues that inhibit the ultra-rapidly-activating delayed rectifier potassium current (IKur or IKsus), transient outward potassium (Ito), and acetylcholine-activated potassium current (IK.ACh).
    Type: Application
    Filed: February 29, 2008
    Publication date: September 4, 2008
    Inventors: Gui-Rong Li, Chu-Pak Lau, Guo-Wei Qin, Hong-Bing Wang