Abstract: Compositions and methods for treating myotonic dystrophy type 1 (DM1) with SluCas9 and SaCas9 are encompassed.

Abstract: Machine learning-based systems and methods for predicting running-related injuries and related training methods are described herein. An example method for training a machine learning model includes receiving a dataset including running-related data, where the running-related data includes a plurality of samples tagged with respective running-related injury labels. The method also includes augmenting the dataset, where the augmented dataset further includes a plurality of synthetic samples tagged with respective running-related injury labels. The method further includes training a machine learning model using the augmented dataset. The trained machine learning model is configured for predicting risk of running-related injury.

Abstract: A device and method for checking the roundness of ball-point type contacts associated with a measuring device and used to engage a threaded surface of a specific thread type to facilitate measurement of critical dimensional parameters of a threaded member. The device consists of a hard, wear resistant, and dimensionally stable material having formed thereon a reference groove and a comparison groove adjacent flat surfaces. The reference groove conforms in profile to the profile of the thread type while the comparison groove is square-shouldered and wider than deep. The depths of the reference and comparison grooves are selected such that a perfectly round ball-point type contact is insertable into each to the exact same depth relative the respective adjacent surfaces. The method requires attachment of the contact to a dial gage capable of measuring the distance to which the contact extends below a reference plane.

Abstract: An apparatus and method empolying a notched precision caliper in conjunction with a transfer tool such as a conventional dial gauge caliper having ball-point type contact surfaces to provide a direct quantitative indication of a threaded member's pitch diameter deviation from the nominal pitch diameter value by a deflection of the dial gauge.