Patents by Inventor Gunnar Garke

Gunnar Garke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing (4S)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide and purification thereof for use as a pharmaceutical active ingredient
    Patent number: 10399977
    Abstract: The present invention relates to a novel and improved process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I) and also the preparation and use of the crystalline polymorph I of (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I).
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: September 3, 2019
    Assignee: Bayer Pharma Aktiengesellschaft
    Inventors: Johannes Platzek, Gunnar Garke, Alfons Grunenberg
  • Process for preparing (4S)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide and purification thereof for use as a pharmaceutical active ingredient
    Publication number: 20190127369
    Abstract: The present invention relates to a novel and improved process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I) and also the preparation and use of the crystalline polymorph I of (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I).
    Type: Application
    Filed: August 27, 2018
    Publication date: May 2, 2019
    Inventors: Johannes Platzek, Gunnar Garke, Alfons Grunenberg
  • Method for the preparation of (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro- 1-6-naphthyridine-3-carbox-amide and the purification thereof for use as an active pharmaceutical ingredient
    Patent number: 10059707
    Abstract: The present invention relates to a novel and improved process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I) and also the preparation and use of the crystalline polymorph I of (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I).
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: August 28, 2018
    Assignee: BAYER PHARMA AG
    Inventors: Johannes Platzek, Gunnar Garke, Alfons Grunenberg
  • METHOD FOR THE PREPARATION OF (4S)-4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1-6-NAPHTHYRIDINE-3-CARBOX-AMIDE AND THE PURIFICATION THEREOF FOR USE AS AN ACTIVE PHARMACEUTICAL INGREDIENT
    Publication number: 20170217957
    Abstract: The present invention relates to a novel and improved process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I) and also the preparation and use of the crystalline polymorph I of (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I).
    Type: Application
    Filed: July 29, 2015
    Publication date: August 3, 2017
    Applicant: Bayer Pharma Aktiengesellschaft
    Inventors: Johannes PLATZEK, Gunnar GARKE, Alfons GRUNENBERG
  • Method for production of F-18 labeled amyloid beta ligands
    Patent number: 9592308
    Abstract: This invention relates to methods, which provide access to [F-18]fluoropegylated (aryl/heteroaryl vinyl)-phenyl methyl amine derivatives.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: March 14, 2017
    Assignee: PIRAMAL IMAGING SA
    Inventors: Mathias Berndt, Matthias Friebe, Fabrice Samson, Rainer Braun, Gunnar Garke, Marianne Patt, Andreas Schildan, Christoph Smuda
  • METHOD FOR PRODUCTION OF F-18 LABELED AMYLOID BETA LIGANDS
    Publication number: 20160184465
    Abstract: This invention relates to methods, which provide access to [F-18]fluoropegylated (aryl/heteroaryl vinyl)-phenyl methyl amine derivatives.
    Type: Application
    Filed: March 7, 2016
    Publication date: June 30, 2016
    Applicant: PIRAMAL IMAGING SA
    Inventors: Mathias BERNDT, Matthias FRIEBE, Fabrice SAMSON, Rainer BRAUN, Gunnar GARKE, Marianne PATT, Andreas SCHILDAN, Christoph SMUDA
  • METHOD FOR PRODUCTION OF F-18 LABELED AMYLOID BETA LIGANDS
    Publication number: 20130209363
    Abstract: This invention relates to methods, which provide access to [F-18]fluoropegylated (aryl/heteroaryl vinyl)-phenyl methyl amine derivatives.
    Type: Application
    Filed: May 30, 2011
    Publication date: August 15, 2013
    Applicant: PIRAMAL IMAGING SA
    Inventors: Mathias Berndt, Matthias Friebe, Fabrice Samson, Rainer Braun, Gunnar Garke, Marianne PATT, Andreas Schildan, Christoph Smuda
  • Progesterone receptor antagonists
    Patent number: 8053426
    Abstract: The present invention relates to progesterone receptor antagonists of general formula I: in which R1 can be a hydrogen atom and R2 a hydroxyl group or R1 and R2 together can be an oxo group.
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: November 8, 2011
    Assignee: Bayer Schering Pharma AG
    Inventors: Ulrike Fuhrmann, Anja Schmidt, Arwed Cleve, Orlin Petrov, Gunnar Garke, Stefan Pruehs, Margarete Brudny-Kloeppel, Antje Rottmann, Rainer Hasselmann, Marcus Schultze-Mosgau, Carsten Moeller
  • Progesterone receptor antagonists
    Patent number: 7951790
    Abstract: The present invention relates to progesterone receptor antagonists of general formula I: in which R1 can be a hydrogen atom and R2 a hydroxyl group or R1 and R2 together can be an oxo group.
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: May 31, 2011
    Assignee: Bayer Schering Pharma AG
    Inventors: Ulrike Fuhrmann, Anja Schmidt, Arwed Cleve, Orlin Petrov, Gunnar Garke, Stefan Pruehs, Margarete Brudny-Kloeppel, Antje Rottmann, Rainer Hasselmann, Marcus Schultze-Mosgau, Carsten Moeller
  • Progesterone receptor antagonists
    Patent number: 7902178
    Abstract: The present invention relates to progesterone receptor antagonists of general formula I: in which R1 can be a hydrogen atom and R2 a hydroxyl group or R1 and R2 together can be an oxo group.
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: March 8, 2011
    Assignee: Bayer Schering Pharma AG
    Inventors: Ulrike Fuhrmann, Anja Schmidt, Arwed Cleve, Orlin Petrov, Gunnar Garke, Stefan Pruehs, Margarete Brudny-Kloeppel, Antje Rottmann, Rainer Hasselmann, Marcus Schultze-Mosgau, Carsten Moeller
  • Progesterone receptor antagonists
    Publication number: 20080200440
    Abstract: The present invention relates to progesterone receptor antagonists of general formula I: in which R1 can be a hydrogen atom and R2 a hydroxyl group or R1 and R2 together can be an oxo group.
    Type: Application
    Filed: November 15, 2007
    Publication date: August 21, 2008
    Inventors: Ulrike Fuhrmann, Anja Schmidt, Arwed Cleve, Orlin Petrov, Gunnar Garke, Stefan Pruehs, Margarete Brudny-Kloeppel, Antje Rottmann, Rainer Hasselmann, Marcus Schultze-Mosgau, Carsten Moeller
  • Method for the preparation of (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-l,4-dihydro-1-6-naphthyridine-3-carbox-amide and the purification thereof for use as an active pharmaceutical ingredient
    Patent number: RE49575
    Abstract: The present invention relates to a novel and improved process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I) and also the preparation and use of the crystalline polymorph I of (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I).
    Type: Grant
    Filed: August 25, 2020
    Date of Patent: July 11, 2023
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Johannes Platzek, Gunnar Garke, Alfons Grunenberg
  • Process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide and purification thereof for use as pharmaceutical active ingredient
    Patent number: RE49860
    Abstract: The present invention relates to a novel and improved process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I) and also the preparation and use of the crystalline polymorph I of (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I).
    Type: Grant
    Filed: November 3, 2020
    Date of Patent: March 5, 2024
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Johannes Platzek, Gunnar Garke, Alfons Grunenberg