Abstract: The present invention relates to bendamustine derivatives and related compounds of formula (VII), (VIII) and (IX), and medical uses thereof in particular in cancer therapy.

Abstract: This disclosure relates to the release of singlet oxygen by thermally activated decomposition of aromatic endoperoxide molecules in material systems [e.g. polymer (nano)particles or polymer films]. Due to the short lifespan and diffusion length of singlet oxygen, the technical problem is that the majority of the decomposition may only take place if the singlet oxygen molecules can reach the target region. For example, either the penetration of the polymer particles into the cancer cells to be killed, or the settlement of bacteria on an implant coated with the polymer film, must be accomplished. It is necessary to allow adaptation of the time progression of the decomposition for the application. The adaptation is performed by chemically and/or physically modifying the functional structures present in the material system, each made of the molecule forming the endoperoxide and at least one adjacent molecule or the cage formed by all adjacent molecules.

Abstract: The present invention relates to bendamustine derivatives and related compounds of formula (VII), (VIII) and (IX), and medical uses thereof in particular in cancer therapy.

Abstract: The present invention relates to diester prodrugs of cilazaprilate which undergo enzymatic cleavage to release the active metabolite cilazaprilate that is used for the treatment of hypertension and congestive heart failure. Furthermore the diester prodrugs of cilazaprilate possess all the properties necessary to be topically administered, preferably via transdermal therapeutic systems.

Abstract: The present invention relates to diester prodrugs of cilazaprilate which undergo enzymatic cleavage to release the active metabolite cilazaprilate that is used for the treatment of hypertension and congestive heart failure. Furthermore the diester prodrugs of cilazaprilate possess all the properties necessary to be topically administered, preferably via transdermal therapeutic systems.

Abstract: The invention relates to the release of singlet oxygen by thermally activated decomposition of aromatic endoperoxide molecules in material systems [e.g. polymer (nano) particles or polymer films]. Due to the short lifespan and diffusion length of singlet oxygen, the technical problem is that the majority of the decomposition may only take place if the singlet oxygen molecules can reach the target region. For example, either the penetration of the polymer particles into the cancer cells to be killed, or the settlement of bacteria on an implant coated with the polymer film, must be accomplished. It is necessary to allow adaptation of the time progression of the decomposition for the application. The adaptation is performed by chemically and/or physically modifying the functional structures present in the material system, each made of the molecule forming the endoperoxide and at least one adjacent molecule or the cage formed by all adjacent molecules.

Abstract: Pyridinium salts of the formula ##STR1## are prepared. The compounds are useful as phase transfer catalysts for the preparation of methacryloyloxyalkylalkoxysilanes and acryloyloxyalkylalkoxysilanes.

Abstract: Pyridinium salts of the formula ##STR1## are prepared. The compounds are useful as phase transfer catalysts for the preparation of methacryloyloxyalkylalkoxysilanes and acryloyloxyalkylalkoxysilanes.

Abstract: A method for making a gas chamber for photometric measuring equipment comprises providing a metal frame with recesses on opposite sides establishing a web and at least one opening in the web and having solder surface areas; providing at least two calcium fluoide panes, said panes each having a rim portion; is improved by providing rim surface portions of the panes about to face the recess-web portion of said metal frame with a plurality of layers, by (i) physical vapor depositing a thin chromium nickel layer, (ii) physical vapor depositing thereon a nickel layer, and (iii) by physical vapor depositing thereon a gold layer; vapor depositing on the web portion around the opening of said recesses a gold layer; providing at least two solder elements of basically ring-shaped configuration respectively to be interposed between the web and the panes, the soldering elements being configured so that between their respective outer contour and walls of the recesses a solder flow space obtains when the solder elements ar

Abstract: A quaternary pyridinium halide is used as the phase transfer catalyst in a process for the preparation of an organosilane containing methacryloyloxy or acryloyloxy groups by reacting an alkali metal methacrylate or alkali metal acrylate with a chloroalkylsilane.

Abstract: The present invention is in the preparation of methacrylic or acryloxyalkylalkoxysilanes by the reaction at a temperature of from 80.degree. and 130.degree. C. of an alkali (meth) acrylate with a halogen alkylalkoxysilane in the presence of a quaternary ammonium salt which has long-chin alkyl moieties, in which the sum of all carbon atoms is between 10 and 40 as a phase-transfer catalyst. In the new procedure no solvents need to be used. The yields are better than 95%.

Abstract: Organosilanes comprising methacryloxy groups or acryloxy groups are stabilized with a mixture consisting of at least one N,N'-di-substituted-p-phenylenediamine and at least one substituted phenol, which yields products with high purity and high yields.

Abstract: Disclosed are casting resins made from acrylic acid esters with a high content of finely dispersed fillers. The casting resins contain a polymeric organosilicon compound having functional and nonfunctional groups. As functional groups, the copolymer contains one or more alkoxysilyl groups and one or more (meth)acryloxysilyl groups. The copolymer furthermore contains by copolymerization at least one nonfunctional comonomer having an ethylenically unsaturated grouping as well as an additional comonomer of the group of the vinyl carboxylic acid esters and (meth)acrylic acid esters, if desired. The addition of these polymeric organosilanes to known casting resins brings about a greater lowering of the viscosity of these resins, which are used, for example, for the manufacture of sanitary appliances.

Abstract: Disclosed are new copolymers which are useful as adhesion mediating agents. The copolymers of the invention are prepared by the copolymerization of vinyl silanes, vinyl esters of alpha-halogen fatty acids and fatty acid vinyl esters, which are then reacted with tertiary amines. The new polymers are soluble in water and in such solutions they can be used as adhesion mediating agents between silicatic and other materials and polymers.

Abstract: The present invention relates to copolymers which can be used as adhesion mediating agents (adhesivers) between polymers and inorganic-oxide material. They are characterized by a reactive alkoxysilyl group and an acrylic or methacrylic acid moiety. Each of these two groups is linked to a fundamental constituent having two chain carbon atoms, this fundamental constituent being constructed on a compound having an ethylenically unsaturated group as monomer. The ratio of the alkoxysilyl groups to the acrylic or methacrylic acid esters in the new copolymers can be established as desired, for example by copolymerizing the copolymers with other compounds having ethylenically unsaturated groups, which do not have the above-named moieties. The present invention also relates to a method of preparing these new copolymers as well as intermediates which occur in the practice of this method, as formerly unknown products.

Abstract: A process for the preparation of Benzaldehydes substituted in the nucleus is disclosed by oxidation of the corresponding benzyl halides. The process is performed in the presence of water using aminoxides of tertiary amines.

Abstract: A method for preparing benzyl alcohols or substituted benzyl alcohols is disclosed by decarbonylation of formic acid esters of benzyl alcohols or ring substituted benzyl alcohols, the decarbonylation being carried out in the presence of a catalyst.

Abstract: There is described an essentially two step process for the preparation of benzylalcohols including those benzylalcohols having substituents on the benzyene ring by reaction of a substituted or unsubstituted benzyl halide with a formate typically an alkali or alkaline earth metal formate to form the corresponding substituted or unsubstituted benzyl formate. In the second step of the process the benzyl formate is contacted with an alcohol whereby the same is converted into the desired benzylalcohol. Both steps can be performed employing catalysts. Described in the specification is the realization of the desired product in exceptionally high yields in a short period of time whereby the process is characterized by high space-time yields.

Abstract: A process for the preparation of a terephthalic, isophthalic or phthalic dialdehyde is described by dehydrogenation of the corresponding xylylene glycol in the vapor phase at 250.degree. to 500.degree. C. The process is carried out in the presence of oxygen, water vapor and a dehydrogenation catalyst, suitably a silver dehydrogenation catalyst.

Abstract: A method of deacetylation of ethylene-vinyl acetate copolymers to produce the corresponding olefinicaly unsaturated, linear polymers. The ethylene-vinyl acetate copolymers are deacetylated under a vacuum of less than about 50 Torr, by splitting acetic acid from the copolymers, and while continuously stirring the copolymers.