Abstract: The present invention provides compounds of formula (I) or (Ia) which are ligands binding to the HDM2 protein, inducing apoptosis and inhibiting proliferation, and having therapeutic utility in cancer therapy and prevention. Compounds of formula (I) or (Ia) can be used as therapeutics for treating stroke, myocardial infarction, ischemia, multi-organ failure, spinal cord injury, Alzheimer's Disease, injury from ischemic events and heart valvular degenerative disease. Moreover, compounds of formula (I) or (Ia) can be used to decrease the side effects from cytotoxic cancer agents, radiation and to treat viral infections.

Abstract: The present invention provides a compound selected from compounds of formula (A) as ligand binding to the HDM2 protein, inducing apoptosis and inhibiting proliferation, and having therapeutic utility in cancer therapy and prevention. Compounds of formula (A) can be used as therapeutics for treating stroke, myocardial infarction, ischemia, multi-organ failure, spinal cord injury, Alzheimer's Disease, injury from ischemic events and heart valvular degenerative disease. Moreover, compounds of formula (A) can be used to decrease the side effects from cytotoxic cancer agents, radiation and to treat viral infections.

Abstract: The present invention provides compounds of formula (I) or (Ia) which are ligands binding to the HDM2 protein, inducing apoptosis and inhibiting proliferation, and having therapeutic utility in cancer therapy and prevention. Compounds of formula (I) or (Ia) can be used as therapeutics for treating stroke, myocardial infarction, ischemia, multi-organ failure, spinal cord injury, Alzheimer's Disease, injury from ischemic events and heart valvular degenerative disease. Moreover, compounds of formula (I) or (Ia) can be used to decrease the side effects from cytotoxic cancer agents, radiation and to treat viral infections.

Abstract: The present invention provides compounds of formula (I) or (Ia) which are ligands binding to the HDM2 protein, inducing apoptosis and inhibiting proliferation, and having therapeutic utility in cancer therapy and prevention. Compounds of formula (I) or (Ia) can be used as therapeutics for treating stroke, myocardial infarction, ischemia, multi-organ failure, spinal cord injury, Alzheimer's Disease, injury from ischemic events and heart valvular degenerative disease. Moreover, compounds of formula (I) or (Ia) can be used to decrease the side effects from cytotoxic cancer agents, radiation and to treat viral infections.

Abstract: The present invention provides compounds of formula (I) or (Ia) which are ligands binding to the HDM2 protein, inducing apoptosis and inhibiting proliferation, and having therapeutic utility in cancer therapy and prevention. Compounds of formula (I) or (Ia) can be used as therapeutics for treating stroke, myocardial infarction, ischemia, multi-organ failure, spinal cord injury, Alzheimer's Disease, injury from ischemic events and heart valvular degenerative disease. Moreover, compounds of formula (I) or (Ia) can be used to decrease the side effects from cytotoxic cancer agents, radiation and to treat viral infections.

Abstract: The present invention provides a compound selected from compounds of formula (A) as ligand binding to the HDM2 protein, inducing apoptosis and inhibiting proliferation, and having therapeutic utility in cancer therapy and prevention. Compounds of formula (A) can be used as therapeutics for treating stroke, myocardial infarction, ischemia, multi-organ failure, spinal cord injury, Alzheimer's Disease, injury from ischemic events and heart valvular degenerative disease. Moreover, compounds of formula (A) can be used to decrease the side effects from cytotoxic cancer agents, radiation and to treat viral infections.

Abstract: The present invention provides a compound selected from compounds of formula I as ligand binding to the HDM2 protein, inducing apoptosis and inhibiting proliferation, and having therapeutic utility in cancer therapy. Compounds of formula (I) can be used as therapeutics for treating stroke, myocardial infarction, ischemia, multi-organ failure, spinal cord injury, Alzheimer's Disease, injury from ischemic events, heart valvular degenerative disease Moreover, compounds of formula (I) can be used to decrease the side effects from cytotoxic cancer agents and to treat viral infections.

Abstract: A coordinate measuring machine with a base frame which is essentially constructed in the mode of a portal or gantry-type structure which concurrently forms a measuring table, and with a cross-carrier which spans over the measuring table and receives a measuring carriage with a spindle, and which supports itself with one arm on a guideway located in front of the measuring table.

Abstract: A coordinate measuring machine has supporting members movable in a plurality of coordinate directions which are each made of welded steel construction. Surfaces of the supporting members are covered by sheet metal shells which are spaced by a small distance away from the supporting members and form an air space thereover. This reduces the adverse influences of temperature induced expansions and contractions.

Abstract: For accurately determining the position of a measuring head 14, a multicoordinate measuring machine has an additional measuring device, which essentially is formed by a scanning head 19 having a measuring probe 20, and inserted in a beam 16. The position of a cross arm 6 in a distance A is determined by means of the measuring probe 20 and is passed on over an amplifier 22 to a computer 25 for control and display purposes. The coordinate measuring machine operates with only one length scale 5. The cross arm 6 is supported at its ends and without play on carriages 11 and 12, which can be moved in the X direction in guiding systems 3 and 4, which are arranged parallel to each other.

Abstract: A portal type coordinate measuring machine includes a column on each side of a measuring table which is movable by a synchronous belt drive connected to each column. A drive motor is centrally mounted on a bridge portion overlying the columns and it drives a horizontal shaft which extends to each column and effects the rotation of a drive pinion which engages a gear belt which extends parallel to each column and is carried by the column. The drive includes a toothed belt or gear belt which is disposed parallel to the guiding ways for the columns and has its ends firmly clamped on the bridge and an active central portion which extends around a drive pinion which is tensioned on respective sides of the drive pinion by tension rolls.

Abstract: A measuring process for evaluation of the machining capability or quality of multi-spindle rotary machining or turning unit utilized for the production of preferably rotationally-symmetrical workpieces which are to be finished on both sides, and for the intermediate and/or final evaluation of workpieces which are finished in that manner. Furthermore, the invention also relates to a measuring installation for the implementation of this measuring process.

Abstract: A coordinate measuring apparatus comprises a frame substantially formed by a rectangular prismatic body and an indexing rotary table which is connected to the front side portion of the prismatic body to form an L-shaped structure. Above the prismatic body, a cantilever arm projects over the rotary table. The cantilever arm is movable at its level, perpendicularly to its longitudinal axis and carries a tail spindle which is equipped with a measuring head. The clear construction of the apparatus which is easy to survey and with its overhead guideways, is an ideal arrangement for applying a linear measuring system.

Abstract: The coordinate measuring machine comprises a basic frame structure including a bearing portion having a steel track with a crossbeam support for traveling on the steel track which carries a spindle sleeve. At least one of the frame structure parts comprises a cast resin concrete with a steel track embedded in the cast part. The composition of the synthetic resin concrete at least in the zones adjacent the steel track is such that the coefficient of thermal expansion of the concrete is substantially equal to that of the steel track.

Abstract: An arrangement for the measuring and correction of the steering geometry of motor vehicles, in particular their alignment and camber angles, through the intermediary of mechanical components associated with each wheel of a wheel pair and which serves for the scanning of the actual value of the wheel angles, whereby the values determined in this manner are converted into electrical signals through the utilization of data pick-ups and are then displayed.