Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: Biguanide compounds of formula where R1 comprises a cubanyl-substituted alkyl and R2 comprises a substituted or unsubstituted alkyl, and their use in the treatment of cancers and viral infections are described.

Abstract: A vacuum interrupter. The vacuum interrupter comprising at least one anode side contact blade, at least one cathode side contact blade, at least one anode side conducting rod, at least one a cathode side conducting rod, a shielding case and an outer magnet, wherein the shielding case covers the at least one anode side contact blade, the c at least one anode side contact blade, the at least one anode side conducting rod and at least one cathode side conducting rod; and the outer magnet covers the shielding case. According to the vacuum interrupter, the outer magnet is arranged to generate a fixed first longitudinal magnetic field in the interelectrode area of the at least one anode side contact blade and the at least one cathode side contact blade, contraction of arcs during current breaking can be alleviated, the arcs are in a diffusion state, and ablation of the contact in the arcing process is reduced, and breaking capacity of a vacuum circuit breaker is guaranteed.

Abstract: A liquid fuel air heater comprises a housing defining a motor housing portion and a grip portion extending from the motor housing portion. An electric motor is positioned in the motor housing portion. A combustion chamber is at least partially positioned within the motor housing portion. A fan is driven by the motor when activated for generating an axial airflow through the combustion chamber. A battery pack containing a plurality of battery cells connected to each other in a series or parallel arrangement is removably coupled to the grip portion of the housing for supplying power to the motor.

Abstract: A class timetable adjustment system with real-time feedback and method thereof are disclosed. A heuristic algorithm and at least one schedule constraint are used to perform calculation to generate an initial class timetable, and a total score is calculated according to a score of the schedule constraint and whether the schedule constraint is satisfied, and a graphical interface including a plurality of block units is generated for displaying the initial class timetable. When one of the block units is dragged, the block unit not allowed to exchange is found, and the found block unit is set with a conflict flag and a conflict description. The system and the method can adjust the total score in real-time, and highlight the block unit with a prompt according to the conflict description, so that to improve the appropriateness and the convenience in scheduling class.

Abstract: A voice coil motor includes a housing having a cavity; a movable assembly received in the cavity; a fixing assembly configured outside of the movable assembly; and a first spring plate and a second spring plate configured at an upper surface and a lower surface of the movable assembly respectively. The fixing assembly comprises at least two magnetic elements connected with the first spring plate and a spacer member configured on the second spring plate to connect the second spring plate to the magnetic elements or the housing. The voice coil motor is served as an actuator of electronic products such as digital cameras, mobile phones, and digital cameras, which has thin thickness, good performance and strong applicability.

Abstract: A filter capable of adjusting frequency and bandwidth for dynamically setting at least one of the filter center frequency and bandwidth includes a first movable member, a second movable member, an upper casing, a lower casing, multiple conductive clamping members, a cavity and a driving module. The first and second movable members have multiple first and second lugs formed on the first and second boards respectively. The upper and lower casings have multiple upper and lower openings corresponsive to the first lugs and the second lugs respectively. The conductive clamping members are corresponsive to the upper openings and the lower openings. The cavity has multiple chambers and multiple connecting portions. The driving module changes the position of the first movable member to determine the filter center frequency and the position of the second movable member to determine the bandwidth.

Abstract: A filter capable of adjusting frequency and bandwidth for dynamically setting at least one of the filter center frequency and bandwidth includes a first movable member, a second movable member, an upper casing, a lower casing, multiple conductive clamping members, a cavity and a driving module. The first and second movable members have multiple first and second lugs formed on the first and second boards respectively. The upper and lower casings have multiple upper and lower openings corresponsive to the first lugs and the second lugs respectively. The conductive clamping members are corresponsive to the upper openings and the lower openings. The cavity has multiple chambers and multiple connecting portions. The driving module changes the position of the first movable member to determine the filter center frequency and the position of the second movable member to determine the bandwidth.

Abstract: A voice coil motor includes a housing having a cavity; a movable assembly received in the cavity; a fixing assembly configured outside of the movable assembly; and a first spring plate and a second spring plate configured at an upper surface and a lower surface of the movable assembly respectively. The fixing assembly comprises at least two magnetic elements connected with the first spring plate and a spacer member configured on the second spring plate to connect the second spring plate to the magnetic elements or the housing. The voice coil motor is served as an actuator of electronic products such as digital cameras, mobile phones, and digital cameras, which has thin thickness, good performance and strong applicability.

Abstract: A method of selectively growing a plurality of semiconductor carbon nanotubes using light irradiation. The method includes disposing a plurality of nanodots, which include a catalyst material, on a substrate; growing a plurality of carbon nanotubes from the plurality of nanodots, and irradiating light onto the nanodot to selectively grow the plurality of semiconductor carbon nanotubes.

Abstract: A toy vehicle comprises a frame, a suspension arm pivotally coupled to the frame and arranged under a portion of the frame, at least one wheel coupled to the suspension arm, and a height switching unit coupled to the frame and the suspension arm and configured to move the portion of the frame between a non-elevated position and an elevated position.

Abstract: A remotely controllable lighting device includes a control circuit, a light source, and an infrared receiver. After any remote controller is set as a designated remote controller, the designated remote controller can be used to control the remotely controllable lighting device. Alternatively, after any remote controller performs a controlled mode enabling operation, the remote controller can be used to control the remotely controllable lighting device. After one remote controller directly emits the infrared signal to the infrared receiver and the control circuit simultaneously performs a stipulated learning operation, the remote controller is set as the designated remote controller. Moreover, before the stipulated learning operation is performed, an action of announcing the stipulated learning operation is not done.

Abstract: A detecting device includes at least one transmitter and plural receivers. After the at least one transmitter emits plural incident light beams to a detection zone, plural reflected light beams reflected from the detection zone are received by the plural receivers. If no object is moved within the detection zone, the plural reflected light beams strike a first part of the plural receivers, so that the plural receivers are in an initial reception configuration. If an object is moved within the detection zone, the plural reflected light beams are disturbed by the object and deflected to a second part of the plural receivers, so that the plural receivers are in a disturbed reception configuration. According to the reception configuration change, a moving direction of the object within the detection zone is determined. Consequently, the detecting range is largely enhanced, and the cost is reduced.

Abstract: A method of selectively growing a plurality of semiconductor carbon nanotubes using light irradiation. The method includes disposing a plurality of nanodots, which include a catalyst material, on a substrate; growing a plurality of carbon nanotubes from the plurality of nanodots, and irradiating light onto the nanodot to selectively grow the plurality of semiconductor carbon nanotubes.

Abstract: A repair device for a PCB includes a clamp portion having a plurality of receptacles defined therein, a connector head having a plurality of contacts configured to connect with the PCB, a plurality of conductive lines arranged side by side, and a lead wire. One end of each of the conductive lines is connected to the clamp portion and exposed to outside of the clamp portion via a corresponding receptacle of the clamp portion, the other end of each of the conductive lines is connected to a corresponding contact of the connector head. Two ends of the lead wire are electrically connected to two of the conductive lines via the corresponding receptacles, thereby switching signal transmission from one of the input terminals of the PCB to another input terminal of the PCB.

Abstract: A simulation method for realizing large batches and different kinds of baseboard management controllers using a single server includes providing a virtual baseboard management controller by a target terminal according to different customized virtual baseboard management controller resources correspondingly. The simulation method includes initializing large batches and different kinds of virtual baseboard controller programs according to a customizable virtual baseboard controller resource. If a client requests to access one baseboard controller or multiple baseboard controllers, which virtual baseboard controller will provide a service is determined according to the information of the accessing request of the client. Then an output result is generated according to the behaviors defined in the customized resource. Finally, the output result is transferred to the client. Therein, the client may connect to the target terminal through Internet or a bus.

Abstract: A position-determining system for determining position and orientation of an object on a work surface parallel to an X-Y plane of a Cartesian coordinate system includes an image-capturing device, a processor and a recognition assistant. The image-capturing device is directed towards the work surface for capturing images of the object and sending the images to the processor. The processor processes the images captured by the image-capturing device. The recognition assistant is attached on the object. The recognition assistant includes a first recognition assistant part and a second recognition assistant part configured to be readily recognizable in an image examined by the processor. Then the processor determines position and orientation of the object via a template matching algorithm.

Abstract: An exemplary multi-window display control system comprises: a read module, a display module, and a display; the method for presenting a multi-window display is also provided, the method comprising: reading the size of a display by a read module; sending the size of the display to a display module; displaying two or more display areas on a display according to a predetermined ratio; and presenting one or more functional units in each of the display area. The multi-window display control system and the method for presenting a multi-window method can provide two or more display areas on an electronic platform simultaneously, as well as provide functional unit windows in the corresponding display areas, which improve the speed and convenience of the operation.

Abstract: A repair device for a PCB includes a clamp portion having a plurality of receptacles defined therein, a connector head having a plurality of contacts configured to connect with the PCB, a plurality of conductive lines arranged side by side, and a lead wire. One end of each of the conductive lines is clamped by the clamp portion and exposed to outside of the clamp portion via a corresponding receptacle of the clamp portion, the other end of each of the conductive lines is connected to a corresponding contact of the connector head. Two ends of the lead wire are electrically connected to two of the conductive lines via the corresponding receptacles, thereby switching signal transmission from one of the input terminal of the PCB to another input terminal of the PCB.

Abstract: A system and method are disclosed for improving hard drive actuator lead attachment. In one embodiment, an actuator board is coupled to an actuator flexible cable by a bonding agent, such as an anisotropic conductive film (ACF). In one embodiment, an actuator flexible cable is coupled to one or more actuator coil leads, such as by solder bump bonding, and the flexible cable/actuator coil coupling is embedded in an actuator frame, such as by polymer injection molding.