Abstract: An auxiliary test paper detection device includes a reagent cap and a test paper cassette. The reagent cap contains a detection reagent, a sealing member is arranged at an opening of the reagent cap. The sealing member can be opened or removed under action of external force. Test paper is arranged in the test paper cassette, a sample absorption section of the test paper is exposed, an observation window is formed in the test paper cassette. A result display area of the test paper corresponds to the observation window. A connecting structure for connecting the test paper cassette and the reagent cap is provided, and when the test paper cassette and the reagent cap are connected through the connecting structure, a closed space is formed in an inner cavity of the reagent cap. The sample absorption section of the test paper extends into the inner cavity of the reagent cap.

Abstract: The disclosure relates an Al—Mg series aluminum alloy sheet, a preparation method and use thereof. The preparation method includes: step S1, melting and casting the alloy raw materials in sequence to obtain an aluminum alloy ingot; step S2, subjecting the aluminum alloy ingot to a two-stage homogenization treatment so as to obtain a homogenized aluminum alloy ingot; and step S3, subjecting the homogenized aluminum alloy ingot to hot rolling, primary cold rolling, intermediate annealing, final cold rolling, and finished product annealing in sequence to obtain the aluminum alloy sheet.

Abstract: The present invention discloses a shed tunnel structure for preventing a falling rock, including a shed tunnel body and a buffer plate for bearing impact of the falling rock, where the shed tunnel body includes a first supporting structure, and the first supporting structure is arranged on a side away from a ramp; one end of the buffer plate is connected to the ramp; a side face of the buffer plate close to the shed tunnel body is in movable contact with the first supporting structure, and the contact position is close to the other end of the buffer plate. The objective of resisting continuous impact of the falling rock can be achieved through the structural design.

Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides compounds of Formula I, pharmaceutical compositions comprising these compounds and methods of using these compounds to prevent or treat FXR-mediated or TGR5-mediated diseases or conditions.

Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts and esters thereof: which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which is associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-1 related disease. The invention also relates to methods of treating an ASK-1 related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-1 associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).

Abstract: Embodiments of this application disclose a backup power supply method and a related device. The method includes: calculating a battery capacity of a battery based on historical power outage alarm information and historical power consumption information of a station in which the battery is located; if a power outage occurs in the station, calculating a state of charge of the battery based on actual power consumption and power outage duration of the station, and the battery capacity; and sending a current target energy saving level of the battery to the station if it is determined, based on the state of charge, that an energy saving level of the battery changes, so that the station uses a power saving policy corresponding to the target energy saving level.

Abstract: Hydrogeological drilling-type detection equipment includes a detection support frame, where the detection support frame is fixedly connected with a detection box body with a through hole, the through hole is communicated with an inside of the detection box body, a drilling box body is arranged inside the through hole, a lifting assembly is arranged inside the detection box body, the drilling box body is slidably connected with the through hole through the lifting assembly, a bottom end of the drilling box body is provided with a multifunctional drilling assembly provided with a blocking assembly, each of four corners of a bottom end of the detection support frame is provided with a moving wheel, the detection support frame is provided with a stable support assembly, the stable support assembly is correspondingly arranged with the moving wheel, and one side of the detection support frame is fixedly connected with an armrest.

Abstract: The present disclosure relates to a magnetic circuit of a loudspeaker and a loudspeaker, which can improve the non-linearity of magnetic permeability, thereby reducing the distortion of the loudspeaker. A magnetic circuit comprises a T-yoke with a base and a columnar portion protruding upward from the base, a magnetic steel arranged on the base, and a front sheet arranged on the magnetic steel, wherein the magnetic steel and the front sheet are arranged around a periphery of the columnar portion, and a short-circuit ring is arranged on an inner side of the magnetic steel and/or the front sheet. A first short-circuit ring is provided between the inner wall of the magnetic steel and the outer wall of the columnar portion, and a second short-circuit ring is provided on the inner wall of the front sheet.

Abstract: A shoulder-angle-adjustable friction stir welding head suitable for a fillet joint includes a stirring head body. A front end of the stirring head body is mounted with a movable shoulder, a stirring pin channel is arranged on the movable shoulder, and the stirring pin channel may allow a stirring pin of the stirring head body to pass through. The present disclosure can respond to welding tasks of the fillet joint of different angles and enlarges an application scope of the friction stir welding head in a manner that the front end of the stirring head body is mounted with the movable shoulder, the stirring pin channel is arranged on the movable shoulder, the stirring pin channel is used for allowing the stirring pin of the stirring head body to pass through, and the angle of the movable shoulder is adjusted.

Abstract: The present invention provides compounds represented by Formula I, or pharmaceutically acceptable salts, stereoisomers, solvates, hydrates or combination thereof, The invention also provides pharmaceutical compositions comprising these compounds and methods of using this compounds for treating FXR-mediated or TGR5-mediated diseases or conditions.

Abstract: Provided are small molecule inhibitors of the KRAS(G12D) mutant oncoprotein having the structural formula: and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions.

Abstract: Clean version of the Abstract A preparation method for growing a germanium sulfide (GeS2) single-crystal thin film on a SiO2 substrate includes: cleaning a surface of a substrate with acetone, ethanol and deionized water, where the substrate is a Si/SiO2 substrate or a SiO2 glass substrate; photoetching the substrate, spin-coating a photoresist, and performing photoetching and dry etching or wet etching to obtain a groove pattern; depositing a germanium (Ge)-crystal layer in the groove pattern of the substrate to obtain a treated substrate; and putting the treated substrate into a chemical vapor deposition (CVD) device for growth, a growth source being high-purity sulfur (S) powder and high-purity Ge powder, thereby obtaining a GeS2 single-crystal thin film on the SiO2 substrate. The preparation method can grow GeS2 single crystals on the SiO2 substrate. The GeS2 single crystals have a high crystalline quality and a small surface roughness.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV) or HMPV. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV or HMPV infection. The invention also relates to methods of treating an RSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: A Near-Field Communication (NFC) antenna and an electronic apparatus include a metal structure on a personal computer (PC), an inductor, a capacitor, and an NFC chip. One end of the metal structure on the PC is coupled to one end of the inductor. The other end of the inductor is coupled to one port of the NFC chip and one end of the capacitor. The other end of the metal structure on the PC is coupled to the other port of the NFC chip and the other end of the capacitor.

Abstract: The present invention relates to a candle which includes a base unit and a candle body which is mounted to the base unit. The candle body includes a wick and a fibre optic running therethrough. The base unit includes a light sensor configured to detect light from the wick, when lit. There is additionally provided a light source configured to operate in dependence on detection of light by the light sensor.

Abstract: An array substrate including a display area having a plurality of subpixels is provided. The plurality of subpixels includes a plurality of first subpixels in a display-bonding sub-area and a plurality of second subpixels in a regular display sub-area. The array substrate includes a plurality of thin film transistors on a first side of the base substrate and respectively in the plurality of subpixels. A respective one of the plurality of first subpixels includes a bonding pad on a second side of a base substrate; a lead line electrically connecting a respective one of a plurality of thin film transistors to the bonding pad; and a via extending through the base substrate. The lead line is unexposed in the array substrate. The lead line extends from the first side to the second side of the base substrate through the via, to connect to the bonding pad.

Abstract: Provided is a display backplate including an array substrate and a plurality of pairs of connection structures on the array substrate, wherein the array substrate includes a plurality of thin-film transistors and a common electrode signal line, wherein at least one of the plurality of thin-film transistors is connected to one of a pair of connection structures and the common electrode signal line is connected to the other of the pair of connection structures; and an area of a first section of the connection structure is negatively correlated with a distance between the first section and a surface of the array substrate, and the first section is parallel to the surface of the array substrate.

Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.