Abstract: The present invention provides high affinity anti-CD40 monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of cancer and other diseases.

Abstract: Provided are modulators of androgen receptor (AR) condensates, methods of modulating or inhibiting AR condensates, and methods of treating diseases and conditions using such modulators or inhibitors of AR condensates.

Abstract: An example apparatus for detecting objects in video frames includes a receiver to receive a plurality of video frames from a video camera. The apparatus also includes a first still image object detector to receive a first frame of the plurality of video frames and calculate localization information and confidence information for each potential object patch in the first frame. The apparatus further includes a second still image object detector to receive an adjacent frame of the plurality of video frames adjacent to the first frame and calculate localization information and confidence information for each potential object patch in the adjacent frame. The apparatus includes a similarity detector trained to detect paired patches between the first frame and the adjacent frame based on a comparison of the detected potential object patches.

Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: According to a method for pushing a notification provided in some embodiments of the present disclosure, a to-be-notified event is obtained; a first notification condition and a second notification condition are determined; a first notification page is displayed on the display when the first notification condition is met, to display, to a user, first association information when the first notification condition is met, for example, event status information, to-be-executed behavior information, and operation association information; and a second notification page is displayed on the display when the second notification condition is met after the first notification page is displayed, to display, to the user, second association information when the second notification condition is met. A plurality of notification pages are pushed for a to-be-notified event, and each notification page is pushed when a notification condition is met as the event develops.

Abstract: A method for manufacturing a fabric with an intelligently-designed digitally-printed pattern with energy saving effect is disclosed. It includes S1: knitting a cotton yarn, a bamboo fiber yarn, and a mulberry silk yarn into a silk-cotton plain knitted single-sided fabric; S2: subjecting the fabric to a double-sided singeing; S3: mercerizing the fabric obtained in step S2; S4: subjecting the mercerized fabric to a neutralizing processing, a bleaching processing, a deoxidating processing, and a whitening processing in sequence; S5: setting the base color of the fabric obtained in step S4; S6: subjecting the fabric obtained in step S5 to a sizing and setting treatment, a pattern design treatment, a digital printing, a steaming treatment, and a water washing treatment; S7: subjecting the fabric obtained in step S6 to a soft setting; S8: subjecting the fabric obtained in step S7 to a decating treatment; and S9: pre-shrinking the fabric obtained in S8.

Abstract: A switch assembly including a switch and an interface physically coupled to the switch and configured to be physically coupled to an electrical component, such as a transformer. The switch assembly also includes an interface having electrical hardware electrically coupled to the switch and configured to be electrically coupled to the component. The switch assembly further includes a surge arrester having an insulation member, a grounding jacket formed over a portion of the insulation member and a conductor extending through the insulation member and being electrically coupled to the hardware and the grounding jacket. The interface further includes a releasable connector that is electrically coupled to the conductor and allows the surge arrester to be disconnected from the interface.

Abstract: A method for manufacturing a fabric with an intelligently-designed digitally-printed pattern with energy saving effect is disclosed.

Abstract: A touch LED component and a touch device, and the touch LED component includes a metal cap, a touch button sheathed on an inner wall of the metal cap, and an LED lamp bead coupled to an inner wall of the touch button, a first through hole formed at the top of the metal cap, an induction pin installed at the bottom of the touch button, and an anode pin and a cathode pin installed on both sides of the bottom of the LED lamp bead respectively. The touch device includes a touch panel, a circuit board, and plural touch LED components. The touch LED component with high integration can be packaged by carrier tapes to facilitate automatic plug-ins and simplify production and assembling processes for mass production. The touch device has the features of simple structure, high reliability, good effect and long life.

Abstract: A model construction system, apparatus, and method are provided. The model construction system includes at least one first source apparatus, at least one second source apparatus, and a model construction apparatus. The model construction apparatus receives a de-identification data set from each first source apparatus, receives a parameter set of a source model from each second source apparatus, generates at least one aligned data set by aligning the de-identification data set according to a predetermined data format, trains an original model to an assisted training model with the aligned data set(s), generates at least one updated parameter set according to the parameter set(s) and an assisted training parameter set, updates the assisted training model with one of the updated parameter set(s), and transmits the updated parameter set(s) to the second source apparatus(es). Each second source apparatus updates the source model according to the corresponding updated parameter set.

Abstract: According to a method for pushing a notification provided in some embodiments of the present disclosure, a to-be-notified event is obtained; a first notification condition and a second notification condition are determined; a first notification page is displayed on the display when the first notification condition is met, to display, to a user, first association information when the first notification condition is met, for example, event status information, to-be-executed behavior information, and operation association information; and a second notification page is displayed on the display when the second notification condition is met after the first notification page is displayed, to display, to the user, second association information when the second notification condition is met. A plurality of notification pages are pushed for a to-be-notified event, and each notification page is pushed when a notification condition is met as the event develops.

Abstract: An audio playback device receives an instruction from a user to select a target voice model from a plurality of voice models and assigns the target voice model to a target character in a text. The audio playback device also transforms the text into a speech, and during the process of transforming the text into the speech, transforms sentences of the target character in the text into the speech of the target character according to the target voice model.

Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: According to a method for pushing a notification provided in some embodiments of the present disclosure, a to-be-notified event is obtained; a first notification condition and a second notification condition are determined; a first notification page is displayed on the display when the first notification condition is met, to display, to a user, first association information when the first notification condition is met, for example, event status information, to-be-executed behavior information, and operation association information; and a second notification page is displayed on the display when the second notification condition is met after the first notification page is displayed, to display, to the user, second association information when the second notification condition is met. A plurality of notification pages are pushed for a to-be-notified event, and each notification page is pushed when a notification condition is met as the event develops.

Abstract: A touch LED component and a touch device, and the touch LED component includes a metal cap, a touch button sheathed on an inner wall of the metal cap, and an LED lamp bead coupled to an inner wall of the touch button, a first through hole formed at the top of the metal cap, an induction pin installed at the bottom of the touch button, and an anode pin and a cathode pin installed on both sides of the bottom of the LED lamp bead respectively. The touch device includes a touch panel, a circuit board, and plural touch LED components. The touch LED component with high integration can be packaged by carrier tapes to facilitate automatic plug-ins and simplify production and assembling processes for mass production. The touch device has the features of simple structure, high reliability, good effect and long life.

Abstract: The present invention provides compounds of formula (I) or (II) or a pharmaceutically acceptable salt thereof and their use in modulating the activity of S1P) receptors. Also provided is a pharmaceutical composition comprising the compounds of formula (I) or (II) or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient or carrier.

Abstract: Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compounds or pharmaceutically acceptable salts thereof. The breast cancer may be an ER-positive breast cancer and/or the subject in need of treatment may express a mutant ER-? protein.

Abstract: The present disclosure provides a novel solid state form of pladienolide pyridine compounds, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful.

Abstract: An antenna structure able to function in a 5G environment is disposed on a supporting member within an electronic device. The antenna structure includes a large number of antenna arrays, the antenna arrays include antenna units arranged in a line, and current is fed to each of the antenna units. A wireless communication device with enhanced transmission rates is also provided.