Abstract: The invention relates to the field of medicinal chemistry, in particular to a substituted diaryl compound shown as a formula (I), a preparation method of the substituted diaryl compound, a medicinal preparation containing the substituted diaryl compound and medical application of the substituted diaryl compound. Pharmacological test results show that the substituted diaryl compound disclosed by the invention has a good inhibition effect on cells of human lung cancer (A549), human ovarian cancer (SKOV3), human melanoma (A375) and human colon cancer (LOVO).

Abstract: A method for evaluating a downhole working condition of a PDC bit includes: performing an indoor test, including performing a drilling test in different full-sized cores by using the PDC bit with different degrees of abrasion and balling under condition of given WOB and rotational speed, to acquire change characteristics of a WOB, a rotational speed, a torque, a ROP and a bit vibration of the PDC bit in different time domains; improving and perfecting an existing prediction model and evaluation method for the downhole working condition through data obtained by the test to obtain the method; reading parameters of the WOB, the rotational speed, the torque and the ROP in real time during drilling; determining the downhole working condition of the PDC bit by using the method in the improving and perfecting.

Abstract: Disclosed is a method for surface-modifying titanium alloy, comprising the following steps: carburizing titanium alloy in solid carburizing agent A and solid carburizing agent B, and then performing gas co-infiltration to realize surface modification treatment of titanium alloy; the solid carburizing agent A includes raw materials of charcoal powder a, barium carbonate, calcium carbonate, barium acetate, urea and cerium carbonate, and the solid carburizing agent B includes raw materials of charcoal powder b, barium carbonate, calcium carbonate and cerium carbonate; and the gases used in the gas co-infiltration are ammonia, air and acetylene.

Abstract: The disclosure provides a method of making an iron matrix composite. A Fe—Ni—P composite powder having a particle size of one to two micrometers and a Fe—N powder having a particle size of 100 to 250 nanometers are used as the raw material. The size and axial displacement of pressing heads of a graphite mold are controlled to realize the control of the porosity of porous iron. The composite produced comprises two surface layers of a Fe—Ni—P alloy and an intermediate layer of porous iron having a porosity of 14 to 39%. The method enables a reduced weight of the Fe—Ni—P alloy and enables shock absorption and damping properties to be imparted to the composite. In addition, an optional subsequent deep cryogenic treatment allows the Fe—Ni—P alloy to be subjected to phase transition from a metastable gamma-phase to an alpha-phase, thereby substantially improving the hardness and strength thereof.

Abstract: The disclosure provides a method of making an iron matrix composite. A Fe—Ni—P composite powder having a particle size of one to two micrometers and a Fe—N powder having a particle size of 100 to 250 nanometers are used as the raw material. The size and axial displacement of pressing heads of a graphite mold are controlled to realize the control of the porosity of porous iron. The composite produced comprises two surface layers of a Fe—Ni—P alloy and an intermediate layer of porous iron having a porosity of 14 to 39%. The method enables a reduced weight of the Fe—Ni—P alloy and enables shock absorption and damping properties to be imparted to the composite. In addition, an optional subsequent deep cryogenic treatment allows the Fe—Ni—P alloy to be subjected to phase transition from a metastable gamma-phase to an alpha-phase, thereby substantially improving the hardness and strength thereof.

Abstract: A laser annealing device and methods for annealing using the device are disclosed. The laser annealing device includes: a laser light source system (3); a laser adjusting system (4) that is connected to the laser light source system and is disposed above a wafer (1); a temperature monitoring system (5) that is disposed above the wafer (1) and configured to measure in real time a temperature at a location of the surface of the wafer at which a light spot is formed; and a central control system (6) in connection with each of the laser light source system, the laser adjusting system, the temperature monitoring system and a wafer table (2). The wafer is jointly annealed by laser beams from several independent lasers (31) in the laser light source system, which have different wavelengths and cooperate in a mutually complementary manner, with a selected optimum set of process parameters. As a result, an optimum annealing temperature can be achieved and surface pattern effects can be effectively reduced.