Patents by Inventor Guofu Zhong
Guofu Zhong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8940938Abstract: Disclosed is a process of carrying out a Michael reaction with recovery of the catalyst, where a compound of formula (1): is reacted with a compound of formula (2): in the presence of a catalyst of formula (4): where the compounds of formulae (1) and (2) undergo a Michael reaction.Type: GrantFiled: May 18, 2010Date of Patent: January 27, 2015Assignee: Nanyang Technological UniversityInventors: Guofu Zhong, Bin Tan, Xuan Zhang, Pei Juan Chua
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Publication number: 20140228564Abstract: Disclosed is a process of enantioselectively forming an aminoxy compound of Formula (3) In formula (3) R1 is one of an aliphatic group and an alicyclic group. R2 is one of hydrogen, an aliphatic group, an alicyclic group, an aromatic group, an arylaliphatic group and an arylalicyclic group. R3 is one of hydrogen, halogen, hydroxyl, and an aliphatic group with a main chain having 1 to about 10 carbon atoms. The respective aliphatic, alicyclic, aromatic, arylaliphatic or arylalicyclic groups of R1, R2, and R3 comprise 0 to about 3 heteroatoms independently selected from the group consisting of N, O, S, Se and Si. The process includes contacting a carbonyl compound of Formula (1) and a nitroso compound of Formula (2) in the presence of a chiral catalyst.Type: ApplicationFiled: February 5, 2014Publication date: August 14, 2014Applicant: Nanyang Technological UniversityInventors: Guofu ZHONG, Min LU, Di ZHU, Pei Juan CHUA, Bin TAN
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Patent number: 8754252Abstract: Disclosed are processes of forming a compound (33), (35) or (37)Type: GrantFiled: July 3, 2012Date of Patent: June 17, 2014Assignee: Nanyang Technological UniversityInventors: Guofu Zhong, Bin Tan, Pei Juan Chua, Zugui Shi
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Patent number: 8680335Abstract: Disclosed is a process of enantioselectively forming an aminoxy compound of Formula (3) In formula (3) R1 is one of an aliphatic group and an alicyclic group. R2 is one of hydrogen, an aliphatic group, an alicyclic group, an aromatic group, an arylaliphatic group and an arylalicyclic group. R3 is one of hydrogen, halogen, hydroxyl, and an aliphatic group with a main chain having 1 to about 10 carbon atoms. The respective aliphatic, alicyclic, aromatic, arylaliphatic or arylalicyclic groups of R1, R2, and R3 comprise 0 to about 3 heteroatoms independently selected from the group consisting of N, O, S, Se and Si. The process includes contacting a carbonyl compound of Formula (1) and a nitroso compound of Formula (2) in the presence of a chiral catalyst.Type: GrantFiled: May 18, 2010Date of Patent: March 25, 2014Assignee: Nanyang Technological UniversityInventors: Guofu Zhong, Min Lu, Di Zhu, Pei Juan Chua, Bin Tan
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Publication number: 20130096338Abstract: Disclosed are processes of forming a compound (33), (35) or (37)Type: ApplicationFiled: July 3, 2012Publication date: April 18, 2013Applicant: Nanyang Technological UniversityInventors: Guofu Zhong, Bin Tan, Pei Juan Chua, Zugui Shi
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Patent number: 8273901Abstract: Disclosed is a process of forming a pyrrole compound. The process comprises contacting an ?-carbonyl oxime compound 1 and an ?,?-unsaturated aldehyde 2 R1 and R2 in compound 1 are independently selected from the group consisting of H, a silyl-group, an aliphatic group, an alicyclic group, an aromatic group, an arylaliphatic group, and an arylalicyclic group. The aliphatic, alicyclic, aromatic, arylaliphatic, and arylalicyclic groups comprise 0 to about 3 heteroatoms selected from the group N, O, S, Se and Si. R3 in aldehyde 2 is selected from the group consisting of H, a silyl-group, an aliphatic group, an alicyclic group, an aromatic group, an arylaliphatic group, and an arylalicyclic group. The aliphatic, alicyclic, aromatic, arylaliphatic, and arylalicyclic groups comprise 0 to about 3 heteroatoms selected from the group N, O, S, Se and Si. The ?-carbonyl oxime compound 1 an the ?,?-unsaturated aldehyde 2 are contacted in a suitable solvent in the presence of a secondary amine.Type: GrantFiled: May 18, 2010Date of Patent: September 25, 2012Assignee: Nanyang Technical UniversityInventors: Guofu Zhong, Bin Tan, Zugui Shi, Pei Juan Chua
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Publication number: 20120004424Abstract: Disclosed is a process of carrying out a Michael reaction with recovery of the catalyst, where a compound of formula (1): is reacted with a compound of formula (2): in the presence of a catalyst of formula (4): where the compounds of formulae (1) and (2) undergo a Michael reaction.Type: ApplicationFiled: May 18, 2010Publication date: January 5, 2012Applicant: NANYANG TECHNOLOGICAL UNIVERSITYInventors: GUOFU ZHONG, BIN TAN, XUAN ZHANG, PEI JUAN CHUA
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Publication number: 20110224429Abstract: Disclosed is a process of enantioselectively forming an aminoxy compound of Formula (3) In formula (3) R1 is one of an aliphatic group and an alicyclic group. R2 is one of hydrogen, an aliphatic group, an alicyclic group, an aromatic group, an arylaliphatic group and an arylalicyclic group. R3 is one of hydrogen, halogen, hydroxyl, and an aliphatic group with a main chain having 1 to about 10 carbon atoms. The respective aliphatic, alicyclic, aromatic, arylaliphatic or arylalicyclic groups of R1, R2, and R3 comprise 0 to about 3 heteroatoms independently selected from the group consisting of N, O, S, Se and Si. The process includes contacting a carbonyl compound of Formula (1) and a nitroso compound of Formula (2) in the presence of a chiral catalyst.Type: ApplicationFiled: May 18, 2010Publication date: September 15, 2011Applicant: Nanyang Technological UniversityInventors: Guofu Zhong, Min Lu, Di Zhu, Pei Juan Chua, Bin Tan
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Publication number: 20110124881Abstract: Disclosed is a process of forming a pyrrole compound. The process comprises contacting an ?-carbonyl oxime compound 1 and an ?,?-unsaturated aldehyde 2 R1 and R2 in compound 1 are independently selected from the group consisting of H, a silyl-group, an aliphatic group, an alicyclic group, an aromatic group, an arylaliphatic group, and an arylalicyclic group. The aliphatic, alicyclic, aromatic, arylaliphatic, and arylalicyclic groups comprise 0 to about 3 heteroatoms selected from the group N, O, S, Se and Si. R3 in aldehyde 2 is selected from the group consisting of H, a silyl-group, an aliphatic group, an alicyclic group, an aromatic group, an arylaliphatic group, and an arylalicyclic group. The aliphatic, alicyclic, aromatic, arylaliphatic, and arylalicyclic groups comprise 0 to about 3 heteroatoms selected from the group N, O, S, Se and Si. The ?-carbonyl oxime compound 1 an the ?,?-unsaturated aldehyde 2 are contacted in a suitable solvent in the presence of a secondary amine.Type: ApplicationFiled: May 18, 2010Publication date: May 26, 2011Inventors: Guofu Zhong, Bin Tan, Zugui Shi, Pei Juan Chua
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Publication number: 20100298576Abstract: Disclosed are processes of forming a compound (33), (35) or (37)Type: ApplicationFiled: May 18, 2010Publication date: November 25, 2010Inventors: Guofu ZHONG, Bin Tan, Pei Juan Chua, Zugui Shi
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Patent number: 7666658Abstract: Nine efficient aldolase antibodies were generated using hapten 2. This hapten combines, in a single molecule, structural components employed for reactive immunization with structural components employed for forming a transition state analog of the aldol reaction. Characterization of two of these antibodies reveals that they are highly proficient (up to 1000-fold better than any other antibody catalyst) and enantioselective catalysts for aldol and retro-aldol reactions and exhibit enantio- and diastereo-selectivities opposite that of antibody 38C2.Type: GrantFiled: October 6, 2000Date of Patent: February 23, 2010Assignee: The Scripps Research InstituteInventors: Carlos F. Barbas, Richard A. Lerner, Guofu Zhong
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Patent number: 6589766Abstract: Catalytic antibodies, including 38C2 and 33F12, are capable of efficiently catalyzing a wide variety of ketone-ketone, ketone-aldehyde, aldehyde-ketone, and aldehyde-aldehyde intermolecular aldol reactions, and in some cases to catalyze their subsequent dehydration to yield aldol condensation products. A number of intramolecular aldol reactions have also been defined. Catalysis of all intramolecular aldol reactions examined yields the corresponding condensation products.Type: GrantFiled: September 25, 2001Date of Patent: July 8, 2003Assignee: The Scripps Research InstituteInventors: Carlos F. Barbas, Richard A. Lerner, Guofu Zhong, Benjamin List
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Patent number: 6326176Abstract: Catalytic antibodies, including 38C2 and 33F12, are capable of efficiently catalyzing a wide variety of ketone-ketone, ketone-aldehyde, aldehyde-ketone, and aldehyde-aldehyde intermolecular aldol reactions, and in some cases to catalyze their subsequent dehydration to yield aldol condensation products. A number of intramolecular aldol reactions have also been defined. Catalysis of all intramolecular aldol reactions examined yields the corresponding condensation products.Type: GrantFiled: May 18, 2000Date of Patent: December 4, 2001Assignee: The Scripps Research InstituteInventors: Carlos F. Barbas, Richard A. Lerner, Guofu Zhong, Benjamin List
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Patent number: 6309881Abstract: Nine efficient aldolase antibodies were generated using hapten 2. This hapten combines, in a single molecule, structural components employed for reactive immunization with structural components employed for forming a transition state analog of the aldol reaction. Characterization of two of these antibodies reveals that they are highly proficient (up to 1000-fold better than any other antibody catalyst) and enantioselective catalysts for aldol and retro-aldol reactions and exhibit enantio- and diastereo-selectivities opposite that of antibody 38C2.Type: GrantFiled: April 2, 2001Date of Patent: October 30, 2001Assignee: The Scripps Research InstituteInventors: Carlos F. Barbas, Richard A. Lerner, Guofu Zhong
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Publication number: 20010018201Abstract: Nine efficient aldolase antibodies were generated using hapten 2. This hapten combines, in a single molecule, structural components employed for reactive immunization with structural components employed for forming a transition state analog of the aldol reaction. Characterization of two of these antibodies reveals that they are highly proficient (up to 1000-fold better than any other antibody catalyst) and enantioselective catalysts for aldol and retro-aldol reactions and exhibit enantio- and diastereo-selectivities opposite that of antibody 38C2.Type: ApplicationFiled: April 2, 2001Publication date: August 30, 2001Inventors: Carlos F. Barbas, Richard A. Lerner, Guofu Zhong
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Patent number: 6210938Abstract: Nine efficient aldolase antibodies were generated using hapten 2. This hapten combines, in a single molecule, structural components employed for reactive immunization with structural components employed for forming a transition state analog of the aldol reaction. Characterization of two of these antibodies reveals that they are highly proficient (up to 1000-fold better than any other antibody catalyst) and enantioselective catalysts for aldol and retro-aldol reactions and exhibit enantio- and diastereo- selectivities opposite that of antibody 38C2.Type: GrantFiled: December 9, 1999Date of Patent: April 3, 2001Assignee: The Scripps Research InstituteInventors: Carlos F. Barbas, Richard A. Lerner, Guofu Zhong