Abstract: A bolt terminal mounted on a guide rail is provided. The bolt terminal comprises a housing (1), an integral nut (2), a screw (3), a connection component (4), and a wiring metal surface (5); one end of the screw is provided in the housing, the other end of the screw is located outside the housing, and the screw located outside the housing is to be connected to the integral nut fitted therewith; the wiring metal surface is provided on the interface between the screw and the housing; and the housing is to be connected to the guide rail via the connection component. The bolt terminal increases the requirement for powering the wirings, and the bolt terminal can be removed from the guide rail only by using a conventional screwdriver to lightly tap on a removal port. The screw is integrally connected to the housing by injection molding and thus there is no risk of the screw falling off, enabling higher reliability.

Abstract: A method and a drug delivery system for transdermally administering parathyroid hormone (PTH) in a pulsatile fashion are provided, where the drug delivery system comprises an array of microprojections each comprising PTH.

Abstract: A soil bed covering and planting apparatus is adapted to be carried along the length of a soil bed by a conveyer vehicle and includes a cover material reel configured to retain and supply a sheet of cover material, and a compaction roller configured to feed cover material over a soil bed and to press the cover material onto the soil bed. Two spike hammers are positioned adjacent to and at opposite sides of the compaction roller, each being configured to drive at least one spike through the cover material into the soil bed. An actuation structure is associated with each spike hammer and urges the spike hammer against a spike. A piercing assembly forms a series of holes in the sheet of cover material and engages with a drive structure that reciprocates the piercing assembly to drive one end of the piercing assembly through the sheet of cover material.

Abstract: A microprojection array comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a therapeutic agent that is poorly soluble in water or an aqueous solvent.

Abstract: Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a short duration of time. The compositions include a low molecular weight biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

Abstract: A microprojection array comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a therapeutic agent that is poorly soluble in water or an aqueous solvent.

Abstract: An injectable depot formulation includes a biocompatible polymer, an organic solvent combined with the biocompatible polymer to form a viscous gel, and a small molecule drug incorporated in the viscous gel such that the formulation exhibits an in vivo release profile having a Cmax to Cmin ratio of less than 200 and a lag time less than 0.2.

Abstract: Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a short duration of time. The compositions include a low molecular weight biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

Abstract: Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a short duration of time. The compositions include a low molecular weight biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

Abstract: Microstructure arrays and methods for using and manufacturing the arrays are described.

Abstract: A circuit inhibits single-ended analogue signal noises and can be included in a terminal accessory. The circuit includes an input interface module, a differential amplification module, an analogue signal processing module, an isolation module and a control module, wherein the input interface module at least includes an analogue signal line and a digital signal line, the differential amplification module includes differential input ends and an output end; the analogue signal line and the digital signal line of the input interface module are respectively connected to the differential input ends of the differential amplification module, so that the analogue signal line and the digital signal line form a pseudo-differential pair, and the output end of the differential amplification module is connected to the analogue signal processing module; the digital signal line is further connected to the isolation module, and the isolation module is further connected to the control module.

Abstract: An injectable depot formulation includes a biocompatible polymer, an organic solvent combined with the biocompatible polymer to form a viscous gel, and a small molecule drug incorporated in the viscous gel such that the formulation exhibits an in vivo release profile having a Cmax to Cmin ratio of less than 200 and a lag time less than 0.2.

Abstract: Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a short duration of time. The compositions include a low molecular weight biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

Abstract: Microstructure arrays and methods for using and manufacturing the arrays are described.

Abstract: A microprojection array comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a therapeutic macromolecule and a stabilizing excipient. Described herein are microstructures having a proximal and distal layer, wherein the distal layer which contains the therapeutic molecule does not rely on the presence of a structure-forming polymer to impart the mechanical strength necessary to penetrate the skin. Methods of forming the array, and methods of using the array are contemplated.

Abstract: Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a short duration of time. The compositions include a low molecular weight biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

Abstract: In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.