Patents by Inventor Guohua Zhao

Guohua Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11884661
    Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are antagonists to ?V-containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of ?v-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.
    Type: Grant
    Filed: February 24, 2021
    Date of Patent: January 30, 2024
    Assignee: Bristol-Myers Squibb Company
    Inventors: Guohua Zhao, Pratik Devasthale, Xiang-Yang Ye, Kumaravel Selvakumar, Suresh Dhanusu, Palanikumar Balasubramanian, Leatte R. Guernon, Rita Civiello, Xiaojun Han, Michael Frederick Parker, Swanee E. Jacutin-Porte
  • Patent number: 11639353
    Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are antagonists to ?v-containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of ?v-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.
    Type: Grant
    Filed: March 25, 2021
    Date of Patent: May 2, 2023
    Assignee: Bristol-Myers Squibb Company
    Inventors: Pratik Devasthale, Fang Moore, Guohua Zhao, Susan Nicole Pieniazek, Kumaravel Selvakumar, Suresh Dhanusu, Manoranjan Panda, Lawrence R. Marcin
  • Patent number: 11292802
    Abstract: The disclosure relates to compounds of formula I: Formula I which inhibit ?V-containing integrins, and includes pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of ?V-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders.
    Type: Grant
    Filed: November 5, 2018
    Date of Patent: April 5, 2022
    Assignee: Bristol-Myers Squibb Company
    Inventors: Guohua Zhao, James Mignone
  • Patent number: 11114035
    Abstract: A pixel circuit and a display device. The pixel circuit includes a charging unit, a light-emitting unit and an error compensation unit; a voltage storage terminal of the charging unit is connected to a voltage input terminal of the light-emitting unit; one end of the error compensation unit is connected to the voltage storage terminal of the charging unit, a voltage at the voltage storage terminal of the charging unit is used to determine a magnitude of a current flowing through the light-emitting unit; a control terminal of the error compensation unit is configured to receive a light-emitting control signal which is used to control the light-emitting unit to emit light or stop emitting light, the error compensation unit is configured to lower the voltage at the voltage storage terminal of the charging unit when the light-emitting control signal controls the light-emitting unit to emit light.
    Type: Grant
    Filed: August 25, 2020
    Date of Patent: September 7, 2021
    Assignee: KunShan Go-Visionox Opto-Electronics Co., Ltd
    Inventors: Guohua Zhao, Bingwen Jin, Siming Hu, Zhenzhen Han, Hui Zhu
  • Patent number: 11100868
    Abstract: The present application provides a display device, a display panel and a capacitance compensation method thereof. A standard for performing a capacitance compensation on row scan lines in a first display region having fewer pixel units is that total load capacitance of a row scan line of a row adjacent to a second display region is equal to self-load capacitance of a row scan line of any row in the second display region, and that total load capacitance of each of the row scan lines decreases smoothly from the row adjacent to the second display region to a row away from the second display region.
    Type: Grant
    Filed: July 8, 2020
    Date of Patent: August 24, 2021
    Assignee: KUNSHAN GO-VISIONOX OPTO-ELECTRONICS CO., LTD.
    Inventors: Guohua Zhao, Jianlong Wu
  • Publication number: 20210246136
    Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are antagonists to ?v-containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of ?v-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.
    Type: Application
    Filed: March 25, 2021
    Publication date: August 12, 2021
    Inventors: Pratik Devasthale, Fang Moore, Guohua Zhao, Susan Nicole Pieniazek, Kumaravel Selvakumar, Suresh Dhanusu, Manoranjan Panda, Lawrence R. Marcin
  • Publication number: 20210188847
    Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are antagonists to ?V-containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of ?v-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.
    Type: Application
    Filed: February 24, 2021
    Publication date: June 24, 2021
    Inventors: Guohua Zhao, Pratik Devasthale, Xiang-Yang Ye, Kumaravel Selvakumar, Suresh Dhanusu, Palanikumar Balasubramanian, Leatte R. Guernon, Rita Civiello, Xiaojun Han, Michael Frederick Parker, Swanee E. Jacutin-Porte
  • Publication number: 20210161869
    Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.
    Type: Application
    Filed: February 17, 2021
    Publication date: June 3, 2021
    Inventors: Huji Turdi, Jon J. Hangeland, R. Michael Lawrence, Saleem Ahmad, Wei Meng, Robert Paul Brigance, Pratik Devasthale, Guohua Zhao
  • Publication number: 20210163501
    Abstract: The disclosure relates to compounds of formula I: Formula I which inhibit ?V-containing integrins, and includes pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of ?V-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders.
    Type: Application
    Filed: November 5, 2018
    Publication date: June 3, 2021
    Inventors: Guohua Zhao, James Mignone
  • Patent number: 11014922
    Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are antagonists to ?v-containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of av-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: May 25, 2021
    Assignee: Bristol-Myers Squibb Company
    Inventors: Pratik Devasthale, Fang Moore, Guohua Zhao, Susan Nicole Pieniazek, Kumaravel Selvakumar, Suresh Dhanusu, Manoranjan Panda, Lawrence R. Marcin
  • Patent number: 10968219
    Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are antagonists to ?v-containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of ay-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: April 6, 2021
    Assignee: Bristol-Myers Squibb Company
    Inventors: Guohua Zhao, Pratik Devasthale, Xiang-Yang Ye, Kumaravel Selvakumar, Suresh Dhanusu, Palanikumar Balasubramanian, Leatte R. Guernon, Rita Civiello, Xiaojun Han, Michael Frederick Parker, Swanee E. Jacutin-Porte
  • Patent number: 10966967
    Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.
    Type: Grant
    Filed: May 21, 2020
    Date of Patent: April 6, 2021
    Assignee: Bristol-Myers Squibb Company
    Inventors: Huji Turdi, Jon J. Hangeland, R. Michael Lawrence, Saleem Ahmad, Wei Meng, Robert Paul Brigance, Pratik Devasthale, Guohua Zhao
  • Patent number: 10902788
    Abstract: The present application provides a scan driver, a driving method thereof and an organic light emitting display. The scan driver includes a first driving area and a second driving area. The first driving area includes a number of first driving units, and the number of the first driving units sequentially sends a first driving signal and a third driving signal to a scan line. The second driving area includes a number of second driving units, and the number of the second driving units sequentially sends a second driving signal to the scan line.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: January 26, 2021
    Assignee: KunShan Go-Visionox Opto-Electronics Co., Ltd.
    Inventors: Guohua Zhao, Siming Hu, Lu Zhang, Zhenzhen Han, Hui Zhu
  • Publication number: 20200388226
    Abstract: A pixel circuit and a display device. The pixel circuit includes a charging unit, a light-emitting unit and an error compensation unit; a voltage storage terminal of the charging unit is connected to a voltage input terminal of the light-emitting unit; one end of the error compensation unit is connected to the voltage storage terminal of the charging unit, a voltage at the voltage storage terminal of the charging unit is used to determine a magnitude of a current flowing through the light-emitting unit; a control terminal of the error compensation unit is configured to receive a light-emitting control signal which is used to control the light-emitting unit to emit light or stop emitting light, the error compensation unit is configured to lower the voltage at the voltage storage terminal of the charging unit when the light-emitting control signal controls the light-emitting unit to emit light.
    Type: Application
    Filed: August 25, 2020
    Publication date: December 10, 2020
    Applicant: KunShan Go-Visionox Opto-Electronics Co., Ltd
    Inventors: Guohua ZHAO, Bingwen JIN, Siming HU, Zhenzhen HAN, Hui ZHU
  • Publication number: 20200335043
    Abstract: The present application provides a display device, a display panel and a capacitance compensation method thereof. A standard for performing a capacitance compensation on row scan lines in a first display region having fewer pixel units is that total load capacitance of a row scan line of a row adjacent to a second display region is equal to self-load capacitance of a row scan line of any row in the second display region, and that total load capacitance of each of the row scan lines decreases smoothly from the row adjacent to the second display region to a row away from the second display region.
    Type: Application
    Filed: July 8, 2020
    Publication date: October 22, 2020
    Inventors: Guohua ZHAO, Jianlong WU
  • Publication number: 20200281905
    Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.
    Type: Application
    Filed: May 21, 2020
    Publication date: September 10, 2020
    Inventors: Huji Turdi, Jon J. Hangeland, R. Michael Lawrence, Saleem Ahmad, Wei Meng, Robert Paul Brigance, Pratik Devasthale, Guohua Zhao
  • Patent number: 10730863
    Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds modulate the activity of farnesoid X receptor (FXR), for example, as agonists. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with FXR dysregulation, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: August 4, 2020
    Assignee: Bristol-Myers Squibb Company
    Inventors: David S. Yoon, Rushith Kumar Anumula, Srinivas Cheruku, Yanting Huang, Elizabeth Anne Jurica, Wei Meng, Susheel Jethanand Nara, Rishikesh Narayan, Ramesh Kumar Sistla, Ximao Wu, Guohua Zhao
  • Publication number: 20200234650
    Abstract: A pixel circuit includes: nine transistors named after the first through the ninth, a capacitor, and a light emitting diode. A first electrode of the fourth transistor is connected to second electrode of third transistor, control end of first transistor and first polar plate of capacitor. A second electrode of fourth transistor is connected to second electrode of seventh transistor. A first electrode of seventh transistor is connected to anode of the light emitting diode and second electrode of the sixth transistor. A first electrode of the sixth transistor is connected to second electrode of the first transistor and first electrode of the third transistor. A second electrode is connected to first electrode of the first transistor, first electrode of the ninth transistor, and second electrode of the fifth transistor. A second electrode is connected to second polar plate of the capacitor and second electrode of the ninth transistor.
    Type: Application
    Filed: April 7, 2020
    Publication date: July 23, 2020
    Inventors: Zhengyong ZHU, Guohua ZHAO, Hui ZHU
  • Patent number: 10717736
    Abstract: The present invention provides compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are inhibitors to ?v-containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of ?v-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: July 21, 2020
    Assignee: Bristol-Myers Squibb Company
    Inventors: Guohua Zhao, James Mignone
  • Patent number: 10695328
    Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: June 30, 2020
    Assignee: Bristol-Myers Squibb Company
    Inventors: Huji Turdi, Jon J. Hangeland, R. Michael Lawrence, Saleem Ahmad, Wei Meng, Robert Paul Brigance, Pratik Devasthale, Guohua Zhao