Patents by Inventor Guohua Zhao
Guohua Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11884661Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are antagonists to ?V-containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of ?v-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.Type: GrantFiled: February 24, 2021Date of Patent: January 30, 2024Assignee: Bristol-Myers Squibb CompanyInventors: Guohua Zhao, Pratik Devasthale, Xiang-Yang Ye, Kumaravel Selvakumar, Suresh Dhanusu, Palanikumar Balasubramanian, Leatte R. Guernon, Rita Civiello, Xiaojun Han, Michael Frederick Parker, Swanee E. Jacutin-Porte
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Patent number: 11639353Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are antagonists to ?v-containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of ?v-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.Type: GrantFiled: March 25, 2021Date of Patent: May 2, 2023Assignee: Bristol-Myers Squibb CompanyInventors: Pratik Devasthale, Fang Moore, Guohua Zhao, Susan Nicole Pieniazek, Kumaravel Selvakumar, Suresh Dhanusu, Manoranjan Panda, Lawrence R. Marcin
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Patent number: 11292802Abstract: The disclosure relates to compounds of formula I: Formula I which inhibit ?V-containing integrins, and includes pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of ?V-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders.Type: GrantFiled: November 5, 2018Date of Patent: April 5, 2022Assignee: Bristol-Myers Squibb CompanyInventors: Guohua Zhao, James Mignone
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Patent number: 11114035Abstract: A pixel circuit and a display device. The pixel circuit includes a charging unit, a light-emitting unit and an error compensation unit; a voltage storage terminal of the charging unit is connected to a voltage input terminal of the light-emitting unit; one end of the error compensation unit is connected to the voltage storage terminal of the charging unit, a voltage at the voltage storage terminal of the charging unit is used to determine a magnitude of a current flowing through the light-emitting unit; a control terminal of the error compensation unit is configured to receive a light-emitting control signal which is used to control the light-emitting unit to emit light or stop emitting light, the error compensation unit is configured to lower the voltage at the voltage storage terminal of the charging unit when the light-emitting control signal controls the light-emitting unit to emit light.Type: GrantFiled: August 25, 2020Date of Patent: September 7, 2021Assignee: KunShan Go-Visionox Opto-Electronics Co., LtdInventors: Guohua Zhao, Bingwen Jin, Siming Hu, Zhenzhen Han, Hui Zhu
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Patent number: 11100868Abstract: The present application provides a display device, a display panel and a capacitance compensation method thereof. A standard for performing a capacitance compensation on row scan lines in a first display region having fewer pixel units is that total load capacitance of a row scan line of a row adjacent to a second display region is equal to self-load capacitance of a row scan line of any row in the second display region, and that total load capacitance of each of the row scan lines decreases smoothly from the row adjacent to the second display region to a row away from the second display region.Type: GrantFiled: July 8, 2020Date of Patent: August 24, 2021Assignee: KUNSHAN GO-VISIONOX OPTO-ELECTRONICS CO., LTD.Inventors: Guohua Zhao, Jianlong Wu
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CYCLOBUTANES- AND AZETIDINE-CONTAINING MONO AND SPIROCYCLIC COMPOUNDS AS ALPHA V INTEGRIN INHIBITORS
Publication number: 20210246136Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are antagonists to ?v-containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of ?v-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.Type: ApplicationFiled: March 25, 2021Publication date: August 12, 2021Inventors: Pratik Devasthale, Fang Moore, Guohua Zhao, Susan Nicole Pieniazek, Kumaravel Selvakumar, Suresh Dhanusu, Manoranjan Panda, Lawrence R. Marcin -
Publication number: 20210188847Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are antagonists to ?V-containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of ?v-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.Type: ApplicationFiled: February 24, 2021Publication date: June 24, 2021Inventors: Guohua Zhao, Pratik Devasthale, Xiang-Yang Ye, Kumaravel Selvakumar, Suresh Dhanusu, Palanikumar Balasubramanian, Leatte R. Guernon, Rita Civiello, Xiaojun Han, Michael Frederick Parker, Swanee E. Jacutin-Porte
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Publication number: 20210161869Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.Type: ApplicationFiled: February 17, 2021Publication date: June 3, 2021Inventors: Huji Turdi, Jon J. Hangeland, R. Michael Lawrence, Saleem Ahmad, Wei Meng, Robert Paul Brigance, Pratik Devasthale, Guohua Zhao
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Publication number: 20210163501Abstract: The disclosure relates to compounds of formula I: Formula I which inhibit ?V-containing integrins, and includes pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of ?V-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders.Type: ApplicationFiled: November 5, 2018Publication date: June 3, 2021Inventors: Guohua Zhao, James Mignone
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Patent number: 11014922Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are antagonists to ?v-containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of av-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.Type: GrantFiled: November 7, 2017Date of Patent: May 25, 2021Assignee: Bristol-Myers Squibb CompanyInventors: Pratik Devasthale, Fang Moore, Guohua Zhao, Susan Nicole Pieniazek, Kumaravel Selvakumar, Suresh Dhanusu, Manoranjan Panda, Lawrence R. Marcin
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Patent number: 10968219Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are antagonists to ?v-containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of ay-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.Type: GrantFiled: November 7, 2017Date of Patent: April 6, 2021Assignee: Bristol-Myers Squibb CompanyInventors: Guohua Zhao, Pratik Devasthale, Xiang-Yang Ye, Kumaravel Selvakumar, Suresh Dhanusu, Palanikumar Balasubramanian, Leatte R. Guernon, Rita Civiello, Xiaojun Han, Michael Frederick Parker, Swanee E. Jacutin-Porte
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Patent number: 10966967Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.Type: GrantFiled: May 21, 2020Date of Patent: April 6, 2021Assignee: Bristol-Myers Squibb CompanyInventors: Huji Turdi, Jon J. Hangeland, R. Michael Lawrence, Saleem Ahmad, Wei Meng, Robert Paul Brigance, Pratik Devasthale, Guohua Zhao
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Patent number: 10902788Abstract: The present application provides a scan driver, a driving method thereof and an organic light emitting display. The scan driver includes a first driving area and a second driving area. The first driving area includes a number of first driving units, and the number of the first driving units sequentially sends a first driving signal and a third driving signal to a scan line. The second driving area includes a number of second driving units, and the number of the second driving units sequentially sends a second driving signal to the scan line.Type: GrantFiled: May 31, 2019Date of Patent: January 26, 2021Assignee: KunShan Go-Visionox Opto-Electronics Co., Ltd.Inventors: Guohua Zhao, Siming Hu, Lu Zhang, Zhenzhen Han, Hui Zhu
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Publication number: 20200388226Abstract: A pixel circuit and a display device. The pixel circuit includes a charging unit, a light-emitting unit and an error compensation unit; a voltage storage terminal of the charging unit is connected to a voltage input terminal of the light-emitting unit; one end of the error compensation unit is connected to the voltage storage terminal of the charging unit, a voltage at the voltage storage terminal of the charging unit is used to determine a magnitude of a current flowing through the light-emitting unit; a control terminal of the error compensation unit is configured to receive a light-emitting control signal which is used to control the light-emitting unit to emit light or stop emitting light, the error compensation unit is configured to lower the voltage at the voltage storage terminal of the charging unit when the light-emitting control signal controls the light-emitting unit to emit light.Type: ApplicationFiled: August 25, 2020Publication date: December 10, 2020Applicant: KunShan Go-Visionox Opto-Electronics Co., LtdInventors: Guohua ZHAO, Bingwen JIN, Siming HU, Zhenzhen HAN, Hui ZHU
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Publication number: 20200335043Abstract: The present application provides a display device, a display panel and a capacitance compensation method thereof. A standard for performing a capacitance compensation on row scan lines in a first display region having fewer pixel units is that total load capacitance of a row scan line of a row adjacent to a second display region is equal to self-load capacitance of a row scan line of any row in the second display region, and that total load capacitance of each of the row scan lines decreases smoothly from the row adjacent to the second display region to a row away from the second display region.Type: ApplicationFiled: July 8, 2020Publication date: October 22, 2020Inventors: Guohua ZHAO, Jianlong WU
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Publication number: 20200281905Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.Type: ApplicationFiled: May 21, 2020Publication date: September 10, 2020Inventors: Huji Turdi, Jon J. Hangeland, R. Michael Lawrence, Saleem Ahmad, Wei Meng, Robert Paul Brigance, Pratik Devasthale, Guohua Zhao
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Patent number: 10730863Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds modulate the activity of farnesoid X receptor (FXR), for example, as agonists. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with FXR dysregulation, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.Type: GrantFiled: October 31, 2018Date of Patent: August 4, 2020Assignee: Bristol-Myers Squibb CompanyInventors: David S. Yoon, Rushith Kumar Anumula, Srinivas Cheruku, Yanting Huang, Elizabeth Anne Jurica, Wei Meng, Susheel Jethanand Nara, Rishikesh Narayan, Ramesh Kumar Sistla, Ximao Wu, Guohua Zhao
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Publication number: 20200234650Abstract: A pixel circuit includes: nine transistors named after the first through the ninth, a capacitor, and a light emitting diode. A first electrode of the fourth transistor is connected to second electrode of third transistor, control end of first transistor and first polar plate of capacitor. A second electrode of fourth transistor is connected to second electrode of seventh transistor. A first electrode of seventh transistor is connected to anode of the light emitting diode and second electrode of the sixth transistor. A first electrode of the sixth transistor is connected to second electrode of the first transistor and first electrode of the third transistor. A second electrode is connected to first electrode of the first transistor, first electrode of the ninth transistor, and second electrode of the fifth transistor. A second electrode is connected to second polar plate of the capacitor and second electrode of the ninth transistor.Type: ApplicationFiled: April 7, 2020Publication date: July 23, 2020Inventors: Zhengyong ZHU, Guohua ZHAO, Hui ZHU
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Patent number: 10717736Abstract: The present invention provides compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are inhibitors to ?v-containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of ?v-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.Type: GrantFiled: November 7, 2017Date of Patent: July 21, 2020Assignee: Bristol-Myers Squibb CompanyInventors: Guohua Zhao, James Mignone
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Patent number: 10695328Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.Type: GrantFiled: June 19, 2019Date of Patent: June 30, 2020Assignee: Bristol-Myers Squibb CompanyInventors: Huji Turdi, Jon J. Hangeland, R. Michael Lawrence, Saleem Ahmad, Wei Meng, Robert Paul Brigance, Pratik Devasthale, Guohua Zhao