Patents by Inventor Guoming Li
Guoming Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240100015Abstract: The present disclosure provides an arctigenin liquid nano-preparation and a preparation method thereof, and relates to the technical field of pharmaceutical preparation. In the present disclosure, arctigenin is prepared into a liquid nano-preparation, having advantages of distribution of a droplet diameter on nanoscale, significantly increased specific surface area, rapid absorption, and high bioavailability. Meanwhile, nano-preparation entered the body can be captured by wandering leucocytes, and a medicament is delivered to inflammatory lesions through chemiotaxis, thereby conferring a targeted drug delivery feature on the arctigenin and making a therapy more targeted. Moreover, in the present disclosure, the arctigenin is dissolved in an oil phase, and the oil phase is dissolved in water by emulsification to further make the arctigenin dissolve in the water and increase water solubility of the arctigenin.Type: ApplicationFiled: November 16, 2022Publication date: March 28, 2024Inventors: Bin HE, Lijun WU, Zheng LU, Zhiping RAN, Guoming CHEN, Zhiyong SHAO, Xiabing CHEN, Wei LIU, Ying LI, Wu LIU, Qi ZHOU, Wenhai YANG, Dongqing LIU, Kangyu DU
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Publication number: 20240091739Abstract: Provided are a mercapto group-loaded layered double hydroxide (LDH)-based magnetic composite particle, and a preparation method and use thereof. The method includes: dissolving a water-soluble divalent magnesium salt and a water-soluble trivalent aluminum salt in water to obtain a mixed salt solution; pumping ammonia water into the mixed salt solution, and performing reaction I under stirring, subjecting an obtained product to centrifugation, and washing product obtained with deionized water; mixing the product with water, ethanol, and a coupling agent KH-580 to obtain a mixture, subjecting the mixture to reaction II while stirring to obtain mercapto group-loaded LDH; mixing the mercapto group-loaded LDH with ferroferric oxide and sodium alginate, adding deionized water thereto, and stirring to obtain a homogeneous mixed solution; adding the homogeneous mixed solution into a calcium chloride solution dropwise to form a magnetic bead; and leaving the magnetic bead to harden, and then washing and drying.Type: ApplicationFiled: September 8, 2023Publication date: March 21, 2024Applicants: Institute of Soil Science, CAS, China Construction Eighth Engrg Division Corp, Ltd.Inventors: Yongming LUO, Guoming Liu, Chen Tu, Shuai Yang, Xiangfeng Huang, Zhongyuan Li, Runlai Luo
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Patent number: 11911257Abstract: An implant delivery tube fitting (12) and an implant delivery system. The implant delivery tube fitting (12) is used for loading and delivering an implant, and the implant delivery tube fitting (12) comprises, sequentially from a proximal end to a distal end, an outer tube (122) and a capsule (121). The inner lumen of the capsule (121) is adapted to receive an implant, and the capsule (121) is provided at the distal end of the outer tube (122). The capsule (121) has a telescopic structure, and the outer tube (122) can drive the capsule (121) to make a telescopic movement so that the capsule (121) is lengthened or shortened.Type: GrantFiled: May 31, 2019Date of Patent: February 27, 2024Assignee: SHANGHAI MICROPORT CARDIOFLOW MEDTECH CO., LTD.Inventors: Xuwen Wu, Baozhu Gui, Xiang Liu, Jing Zhao, Guoming Chen, Yu Li
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Publication number: 20220251149Abstract: The present disclosure provides a pea peptide with auxiliary hypoglycemic function, and preparation method and application thereof. The pea peptide includes at least peptide segments pEE, pEK and pER in its composition; and based on a mass of the pea peptide, a content of the peptide segment pEE is ?100.00 mg/100 g, a content of the peptide segment pEK is ?80.00 mg/100 g and a content of the peptide segment pER is ?90.00 mg/100 g. The pea peptide has a significant efficacy in an aspect of reducing blood glucose.Type: ApplicationFiled: April 26, 2022Publication date: August 11, 2022Inventors: MUYI CAI, Ruizeng GU, LIANG CHEN, YUCHEN WANG, WENYING LIU, YUQING WANG, JING WANG, LU LU, YAGUANG XU, YING WEI, GUOMING LI, XIUYUAN QIN
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Publication number: 20210324428Abstract: A Lactobacillus paracasei and uses thereof. The Lactobacillus paracasei has a deposit number of CGMCC No. 14813. The Lactobacillus paracasei can be used for increasing the amount of an organic acid in a raw material. The Lactobacillus paracasei can be used for fermenting the raw material, where the raw material can be selected from at least one of fruits, which can increase the content of the organic acid in a fermented product.Type: ApplicationFiled: June 30, 2021Publication date: October 21, 2021Inventors: MUYI CAI, Ruizeng GU, Jun LU, KONG LING, LU LU, MING ZHOU, XINYUE CUI, XINGCHANG PAN, ZHE DONG, YONG MA, YAGUANG XU, YONGQING MA, LIANG CHEN, YING WEI, HAIXIN ZHANG, YAN LIU, KELU CAO, JING WANG, GUOMING LI, YUCHEN WANG, YUQING WANG, YUAN BI, XIUYUAN QIN
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Patent number: 11129241Abstract: The utility model discloses a ceramic heating element with multiple temperature zones, which comprises a ceramic heating element. The ceramic heating element consists of a first ceramic substrate, a second ceramic substrate, a heating circuit, an electrode pad, a heating temperature zone, an independent electrode lead and a common electrode, the first ceramic substrate and the second ceramic substrate are stacked and rolled to form a cylindrical or elliptic structure with a center hole, the heating circuit is printed on a front face of the second ceramic substrate, a plurality of electrode pads are printed on a back face of the second ceramic substrate, and a plurality of through holes are machined on an upper surface of the second ceramic substrate. The utility model has the beneficial effects of a simple structure and strong practicability.Type: GrantFiled: June 5, 2018Date of Patent: September 21, 2021Inventor: Guoming Li
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Publication number: 20210230225Abstract: A selenium-chelating pea oligopeptide, a preparation method thereof and use thereof. After the selenium-chelating pea oligopeptide is subjected to digestion treatment in at least one of following three ways, a change rate of selenium content not more than 3% with respect to the selenium content before the digestion treatment: hydrolyzing for 4 hours by a pepsin at a pH value of 2 and a temperature of 37° C.; hydrolyzing for 6 hours by a trypsin at a pH value of 7.5 and a temperature of 37° C.; maintaining the temperature constant at 37° C., firstly hydrolyzing for 4 hours by the pepsin at a pH value of 2, and then continuing to hydrolyze for 6 hours by a trypsin at a pH value of 6.8. The preparation method thereof includes mixing and reacting an aqueous solution of pea oligopeptide and sodium selenite, and then being subjected to alcohol precipitation and drying.Type: ApplicationFiled: April 9, 2021Publication date: July 29, 2021Inventors: MUYI CAI, Ruizeng GU, Jun LU, WENYING LIU, XIUYUAN QIN, XINGCHANG PAN, ZHE DONG, YONG MA, YAGUANG XU, YONGQING MA, LIANG CHEN, LU LU, HAIXIN ZHANG, YING WEI, YAN LIU, KELU CAO, JING WANG, GUOMING LI, MING ZHOU, YUCHEN WANG, YUQING WANG, KONG LING, YUAN BI, XINYUE CUI
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Publication number: 20190274357Abstract: The utility model discloses a ceramic heating element with multiple temperature zones, which comprises a ceramic heating element. The ceramic heating element consists of a first ceramic substrate, a second ceramic substrate, a heating circuit, an electrode pad, a heating temperature zone, an independent electrode lead and a common electrode, the first ceramic substrate and the second ceramic substrate are stacked and rolled to form a cylindrical or elliptic structure with a center hole, the heating circuit is printed on a front face of the second ceramic substrate, a plurality of electrode pads are printed on a back face of the second ceramic substrate, and a plurality of through holes are machined on an upper surface of the second ceramic substrate. The utility model has the beneficial effects of a simple structure and strong practicability.Type: ApplicationFiled: June 5, 2018Publication date: September 12, 2019Inventor: Guoming LI
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Patent number: 9974321Abstract: Disclosed are a fish protein oligopeptide with low allergenicity and slight fishiness, and industrial preparation method and application thereof. The method comprises the following steps: 1) washing fresh fish flesh and/or fish wastes, crushing, and adding water to obtain a mixture; 2) performing thermal denaturation on the mixture to obtain a denaturized protein solution; 3) centrifuging the denaturized protein solution to obtain a precipitate, and adding water into the precipitate and grinding, to obtain a slurry; 4) adjusting the slurry to pH 6-9, and sequentially adding a neutral protease, a papain and an alkaline protease to conduct enzymolysis, and after enzyme inactivation, to obtain an enzymatic hydrolysate; 5) centrifuging the enzymatic hydrolysate, and performing membrane filtration on centrifuged supernatant, to obtain the fish protein oligopeptide with low allergenicity and slight fishiness.Type: GrantFiled: February 24, 2017Date of Patent: May 22, 2018Assignee: CHINA NATIONAL RESEARCH INSTITUTE OF FOOD AND FERMENTATION INDUSTRIESInventors: Muyi Cai, Ruizeng Gu, Jun Lu, Tao Ma, Xingchang Pan, Zhe Dong, Yong Ma, Yaguang Xu, Yongqing Ma, Zhentao Jin, Liang Chen, Lu Lu, Wenying Liu, Ying Wei, Haixin Zhang, Yan Liu, Kelu Cao, Jing Wang, Guoming Li, Ming Zhou
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Publication number: 20170164638Abstract: Disclosed are a fish protein oligopeptide with low allergenicity and slight fishiness, and industrial preparation method and application thereof The method comprises the following steps: 1) washing fresh fish flesh and/or fish wastes, crushing, and adding water to obtain a mixture; 2) performing thermal denaturation on the mixture to obtain a denaturized protein solution; 3) centrifuging the denaturized protein solution to obtain a precipitate, and adding water into the precipitate and grinding, to obtain a slurry; 4) adjusting the slurry to pH 6-9, and sequentially adding a neutral protease, a papain and an alkaline protease to conduct enzymolysis, and after enzyme inactivation, to obtain an enzymatic hydrolysate; 5) centrifuging the enzymatic hydrolysate, and performing membrane filtration on centrifuged supernatant, to obtain the fish protein oligopeptide with low allergenicity and slight fishiness.Type: ApplicationFiled: February 24, 2017Publication date: June 15, 2017Inventors: MUYI CAI, RUIZENG GU, JUN LU, TAO MA, XINGCHANG PAN, ZHE DONG, YONG MA, YAGUANG XU, YONGQING MA, ZHENTAO JIN, LIANG CHEN, LU LU, WENYING LIU, YING WEI, HAIXIN ZHANG, YAN LIU, KELU CAO, JING WANG, GUOMING LI, MING ZHOU
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Publication number: 20170143001Abstract: The present invention provides a soybean oligopeptide with low allergenicity and little bitterness and its preparation method and application. The preparation method includes the following steps: 1) mixing a soybean protein powder with water to obtain a soybean protein solution, and then performing thermal denaturation on the soybean protein solution, to prepare a denatured protein solution; 2) adjusting pH value of the denatured protein solution to 6-9, and then adding a neutral protease and papain to conduct a first enzymolysis, to obtain a first enzymatic hydrolysate; 3) adding an alkaline protease and a flavor protease into the first enzymatic hydrolysate to conduct a second enzymolysis, and after performing enzyme inactivation, to obtain a second enzymatic hydrolysate; and 4) centrifuging the second enzymatic hydrolysate, and performing membrane filtration on centrifuged supernatant liquid, to obtain the soybean oligopeptide with low allergenicity and little bitterness.Type: ApplicationFiled: February 3, 2017Publication date: May 25, 2017Inventors: MUYI CAI, RUIZENG GU, JUN LU, TAO MA, XINGCHANG PAN, ZHE DONG, YONG MA, YAGUANG XU, YONGQING MA, ZHENTAO JIN, LIANG CHEN, LU LU, WENYING LIU, YING WEI, HAIXIN ZHANG, YAN LIU, KELU CAO, JING WANG, GUOMING LI, MING ZHOU, HUI CHEN, JIAJI LI
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Patent number: 7766644Abstract: An injection mold including a connecting structure for separating confronting faces of a slide member and a mold base, respectively, during a movement of the slide member. In accordance with several embodiments of the invention, the connecting structure may include a compressible member such that the slide member is biased away from the mold base, and wherein a positive contact between the confronting surfaces is configurable in response to an applied clamping force between the slide member and the mold base. In accordance with an alternative embodiment of the invention a cam arrangement links the slide member and the mold base enabling a positive contact between the confronting surfaces when the slide member is arranged in the in-mold position, and providing a gap between the confronting surfaces during at least a portion of an interval when the slide member is moving.Type: GrantFiled: March 8, 2007Date of Patent: August 3, 2010Assignee: Husky Injection Molding Systems Ltd.Inventors: Guoming Li, Thomas McGinley
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Publication number: 20090011070Abstract: An injection mold including a connecting structure for separating confronting faces of a slide member and a mold base, respectively, during a movement of the slide member. In accordance with several embodiments of the invention, the connecting structure may include a compressible member such that the slide member is biased away from the mold base, and wherein a positive contact between the confronting surfaces is configurable in response to an applied clamping force between the slide member and the mold base. In accordance with an alternative embodiment of the invention a cam arrangement links the slide member and the mold base enabling a positive contact between the confronting surfaces when the slide member is arranged in the in-mold position, and providing a gap between the confronting surfaces during at least a portion of an interval when the slide member is moving.Type: ApplicationFiled: March 8, 2007Publication date: January 8, 2009Inventors: Guoming Li, Thomas McGinley
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Patent number: 7381049Abstract: An injection mold including a connecting structure for separating confronting faces of a slide member and a mold base, respectively, during a movement of the slide member. In accordance with several embodiments of the invention, the connecting structure may include a compressible member such that the slide member is biased away from the mold base, and wherein a positive contact between the confronting surfaces is configurable in response to an applied clamping force between the slide member and the mold base. In accordance with an alternative embodiment of the invention a cam arrangement links the slide member and the mold base enabling a positive contact between the confronting surfaces when the slide member is arranged in the in-mold position, and providing a gap between the confronting surfaces during at least a portion of an interval when the slide member is moving.Type: GrantFiled: March 8, 2006Date of Patent: June 3, 2008Assignee: Husky Injection Molding Systems Ltd.Inventors: Guoming Li, Thomas McGinley
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Patent number: 7361009Abstract: Disclosed herein is a mold, a molding system and a cooling component. The mold and the molding system use the cooling component. The mold includes a mold cavity plate configured to receive a mold cavity insert. The cooling component includes a jacket configured to define, in combination with the mold cavity insert and the mold cavity plate, a coolant-conveying channel.Type: GrantFiled: October 20, 2005Date of Patent: April 22, 2008Assignee: Husky Injection Molding Systems Ltd.Inventor: Guoming Li
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Publication number: 20070212443Abstract: An injection mold including a connecting structure for separating confronting faces of a slide member and a mold base, respectively, during a movement of the slide member. In accordance with several embodiments of the invention, the connecting structure may include a compressible member such that the slide member is biased away from the mold base, and wherein a positive contact between the confronting surfaces is configurable in response to an applied clamping force between the slide member and the mold base. In accordance with an alternative embodiment of the invention a cam arrangement links the slide member and the mold base enabling a positive contact between the confronting surfaces when the slide member is arranged in the in-mold position, and providing a gap between the confronting surfaces during at least a portion of an interval when the slide member is moving.Type: ApplicationFiled: March 8, 2006Publication date: September 13, 2007Inventors: Guoming Li, Thomas McGinley
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Patent number: 7234930Abstract: A cooling circuit for a neck ring of a preform is conformed to the surface of the neck ring by providing a neck ring in two parts. The first part supports the neck ring and provides strength and durability to the neck ring insert. The second part is formed of porous steel impregnated with highly thermally conductive metal and includes a cooling channel that provides substantially uniform cooling around the neck ring of the preform.Type: GrantFiled: June 14, 2004Date of Patent: June 26, 2007Assignee: Husky Injection Molding Systems Ltd.Inventors: Joachim Johannes Niewels, Michael K. Zuraw, Guoming Li
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Publication number: 20070092596Abstract: Disclosed herein is a mold, a molding system and a cooling component. The mold and the molding system use the cooling component. The mold includes a mold cavity plate configured to receive a mold cavity insert. The cooling component includes a jacket configured to define, in combination with the mold cavity insert and the mold cavity plate, a coolant-conveying channel.Type: ApplicationFiled: October 20, 2005Publication date: April 26, 2007Inventor: Guoming Li
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Publication number: 20050276879Abstract: A cooling circuit for a neck ring of a preform is conformed to the surface of the neck ring by providing a neck ring in two parts. The first part supports the neck ring and provides strength and durability to the neck ring insert. The second part is formed of porous steel impregnated with highly thermally conductive metal and includes a cooling channel that provides substantially uniform cooling around the neck ring of the preform.Type: ApplicationFiled: June 14, 2004Publication date: December 15, 2005Inventors: Joachim Johannes Niewels, Michael Zuraw, Guoming Li