Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides compounds of Formula I, pharmaceutical compositions comprising these compounds and methods of using these compounds to prevent or treat FXR-mediated or TGR5-mediated diseases or conditions.

Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts and esters thereof: which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which is associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-1 related disease. The invention also relates to methods of treating an ASK-1 related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-1 associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).

Abstract: A shoulder-angle-adjustable friction stir welding head suitable for a fillet joint includes a stirring head body. A front end of the stirring head body is mounted with a movable shoulder, a stirring pin channel is arranged on the movable shoulder, and the stirring pin channel may allow a stirring pin of the stirring head body to pass through. The present disclosure can respond to welding tasks of the fillet joint of different angles and enlarges an application scope of the friction stir welding head in a manner that the front end of the stirring head body is mounted with the movable shoulder, the stirring pin channel is arranged on the movable shoulder, the stirring pin channel is used for allowing the stirring pin of the stirring head body to pass through, and the angle of the movable shoulder is adjusted.

Abstract: The present invention provides compounds represented by Formula I, or pharmaceutically acceptable salts, stereoisomers, solvates, hydrates or combination thereof, The invention also provides pharmaceutical compositions comprising these compounds and methods of using this compounds for treating FXR-mediated or TGR5-mediated diseases or conditions.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV) or HMPV. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV or HMPV infection. The invention also relates to methods of treating an RSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: A two-sided time-sharing driving and acquisition system based on dry contacts comprises k dry contacts, a processor, p acquisition circuits, and m driving circuits. The p acquisition circuits are evenly divided into two groups which are separately disposed at two sides of the k dry contacts. The m driving circuits are separately disposed at the two sides of the k dry contacts. A system fault detection method and the two-sided time-sharing driving and acquisition system have the following advantages: the state of input acquisition circuits and cables monitored in real time during system debugging or running, and faults caused by exceptions of the acquisition circuits and the cables can be reported in time.

Abstract: A holding mechanism comprising a holding base, having two oppositely arranged holding grippers with at least one of the two holding grippers being movable. A first resilient biasing member, disposed between the holding base and the movable holding gripper, exerts an elastic biasing force on the movable holding gripper to cause the movable holding gripper to have a tendency to return to its initial position. The holding mechanism includes a locking structure and an unlocking component respectively provided on the holding base. The movable holding gripper moves to a trigger position away from the other holding gripper, and the locking structure locks the movable holding gripper when reaching the trigger position to block the movable holding gripper from returning to its initial position. The unlocking component unlocks the locking structure to remove the blockage of the locking structure to the movable holding gripper.

Abstract: Particles of a macro-porous ion exchange resin are dispersed in a solution of a transition metal compound, such as a compound of molybdenum, tungsten, or vanadium. The resin may be composed for anion exchange or cation ion exchange and, correspondingly, anions or cations of the metal are exchanged onto active ion exchange sites on the molecular chains of the resin. The resin is then carbonized and graphitized to form nanometer-size particles of transition metal carbide on particles of graphite. The composite metal carbide and graphite particles are electrically conductive and serve well as support particles for later deposited particles of a platinum group metal or other catalyst material in, for example, a catalytic electrode member in an electrochemical cell.

Abstract: Particles of a macro-porous ion exchange resin are dispersed in a solution of a transition metal compound, such as a compound of molybdenum, tungsten, or vanadium. The resin may be composed for anion exchange or cation ion exchange and, correspondingly, anions or cations of the metal are exchanged onto active ion exchange sites on the molecular chains of the resin. The resin is then carbonized and graphitized to form nanometer-size particles of transition metal carbide on particles of graphite. The composite metal carbide and graphite particles are electrically conductive and serve well as support particles for later deposited particles of a platinum group metal or other catalyst material in, for example, a catalytic electrode member in an electrochemical cell.