Patents by Inventor Gustavo Rosania

Gustavo Rosania has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DESIGN AND COMPOSITION OF CELL-STABILIZED PHARMACEUTICAL FORMULATIONS
    Publication number: 20190262453
    Abstract: Provided herein are physiologically insoluble insoluble forms of drugs. In particular, provided herein are physiologically insoluble insoluble salts of drugs (e.g., basic drugs) and their use in treatment of disease.
    Type: Application
    Filed: October 24, 2017
    Publication date: August 29, 2019
    Inventors: Gustavo Rosania, Paul J.A. Kenis, Tehetina Woldemichael, Mikhail M. Murashov, Phillip Rzeczycki, Rahul K. Keswani, Elizabeth M. Horstman
  • COMPOSITIONS AND METHODS FOR DELIVERING PHARMACEUTICAL AGENTS
    Publication number: 20160220710
    Abstract: Provided herein are microcrystalline forms of drugs. In particular, provided herein are microcrystalline drug formulations for delivery to macrophages and treatment of disease.
    Type: Application
    Filed: January 29, 2016
    Publication date: August 4, 2016
    Inventors: Rahul K. Keswani, Gi S. Yoon, Kathleen Stringer, Gustavo Rosania, Chao Tian, Xueding Wang
  • Methods for determining the organization of a cellular component of interest
    Patent number: 8050868
    Abstract: The present invention provides automated methods and associated software for determining the organization of a component of interest in individual cells by determining the amount or distribution of the cellular component of interest as a function of position relative to a reference component in the individual cells.
    Type: Grant
    Filed: March 25, 2002
    Date of Patent: November 1, 2011
    Assignee: Cellomics, Inc.
    Inventors: Gustavo Rosania, Paul Sammak, Richard Rubin
  • RNA-selective probes for live cell imaging of nuclear structure and function
    Patent number: 7790896
    Abstract: The present invention is directed to fluorescent compounds and methods of making said compounds that selectively bind to cellular RNA. The fluorescent compounds of the present invention are useful for live cell imaging applications.
    Type: Grant
    Filed: March 1, 2007
    Date of Patent: September 7, 2010
    Assignee: New York University
    Inventors: Young-Tae Chang, Qian Li, Gustavo Rosania
  • Microbead-based test methods for fluorescence imaging systems
    Patent number: 7482167
    Abstract: The present invention provides a test plate and methods for adjusting fluorescence imaging systems involving using a plate with fluorescent microbeads bound to a surface.
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: January 27, 2009
    Assignee: Cellomics, Inc.
    Inventors: Paul Sammak, Gustavo Rosania, Lawrence J. Zana, Kim Ippolito, Jason Bush, Alex Friedman, Sarah Burroughs Tencza, Ravi Kapur
  • RNA-SELECTIVE PROBES FOR LIVE CELL IMAGING OF NUCLEAR STRUCTURE AND FUNCTION
    Publication number: 20080064037
    Abstract: The present invention is directed to fluorescent compounds and methods of making said compounds that selectively bind to cellular RNA. The fluorescent compounds of the present invention are useful for live cell imaging applications.
    Type: Application
    Filed: March 1, 2007
    Publication date: March 13, 2008
    Applicant: NEW YORK UNIVERSITY
    Inventors: Young-Tae CHANG, Qian LI, Gustavo ROSANIA
  • Combinatorial fluorescent library based on the styryl scaffold
    Patent number: 7338428
    Abstract: A combinatorial library of fluorescent compounds useful as organelle-specific probes are produced by reacting an aldehyde with a 2- or 4-methylpyridinium salt.
    Type: Grant
    Filed: July 1, 2004
    Date of Patent: March 4, 2008
    Assignee: New York University
    Inventors: Young-Tae Chang, Gustavo Rosania
  • Chemical address tags
    Publication number: 20070111251
    Abstract: The present invention provides methods and compositions related to the fields of chemoinformatics, chemogenomics, drug discovery and development, and drug targeting. In particular, the present invention provides subcellular localization signals (e.g., chemical address tags) that influence (e.g., direct) subcellular and organelle level localization of associated compounds (e.g., drugs and small molecule therapeutics, radioactive species, dyes and imagining agents, proapoptotic agents, antibiotics, etc) in target cells and tissues. The compositions of the present invention modulate the pharmacological profiles of associated compounds by influencing the compound's accumulation, or exclusion, from subcellular loci such as mitochondria, endoplasmic reticulum, cytoplasm, vesicles, granules, nuclei and nucleoli and other subcellular organelles and compartments.
    Type: Application
    Filed: September 2, 2004
    Publication date: May 17, 2007
    Inventors: Gustavo Rosania, Kerby Shedden
  • Microbead-based test plates and test methods for fluorescence imaging systems
    Publication number: 20050176056
    Abstract: The present invention provides a test plate and methods for adjusting fluorescence imaging systems involving using a plate with fluorescent microbeads bound to a surface.
    Type: Application
    Filed: March 11, 2005
    Publication date: August 11, 2005
    Inventors: Paul Sammak, Gustavo Rosania, Lawrence Zana, Kim Ippolito, Jason Bush, Alex Friedman, Sarah Burroughs Tencza, Ravi Kapur
  • Automated assay for identification of individual cells during kinetic assays
    Patent number: 6917884
    Abstract: The present invention provides methods and software for tracking individual cells during a kinetic cell screening assay.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: July 12, 2005
    Inventors: Paul Sammak, Gustavo Rosania, Richard Rubin, Michel Nederlof, Oleg P. Lapets, Randall O. Shopoff, Murugan Kannan
  • Microbead-based test plates and test methods for fluorescence imaging systems
    Patent number: 6905881
    Abstract: The present invention provides a test plate and methods for adjusting fluorescence imaging systems involving using a plate with fluorescent microbeads bound to a surface.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: June 14, 2005
    Inventors: Paul Sammak, Gustavo Rosania, Lawrence J. Zana, Kim Ippolito, Jason Bush, Alex Friedman, Sarah Burroughs Tencza, Ravi Kapur
  • Combinatorial fluorescent library based on the styryl scaffold
    Publication number: 20050054006
    Abstract: A combinatorial library of fluorescent compounds useful as organelle-specific probes are produced by reacting an aldehyde with a 2- or 4-methylpyridinium salt.
    Type: Application
    Filed: July 1, 2004
    Publication date: March 10, 2005
    Applicant: New York University
    Inventors: Young-Tae Chang, Gustavo Rosania
  • Methods for determining the organization of a cellular component of interest
    Publication number: 20030059093
    Abstract: The present invention provides automated methods and associated software for determining the organization of a component of interest in individual cells by determining the amount or distribution of the cellular component of interest as a function of position relative to a reference component in the individual cells.
    Type: Application
    Filed: March 25, 2002
    Publication date: March 27, 2003
    Applicant: Cellomics, Inc.
    Inventors: Gustavo Rosania, Paul Sammak, Richard Rubin
  • Automated assay for identification of individual cells during kinetic assays
    Publication number: 20030036853
    Abstract: The present invention provides methods and software for tracking individual cells during a kinetic cell screening assay.
    Type: Application
    Filed: December 21, 2001
    Publication date: February 20, 2003
    Applicant: Cellomics, Inc.
    Inventors: Paul Sammak, Gustavo Rosania, Richard Rubin, Michel Nederlof, Oleg P. Lapets, Randall O. Shopoff, Murugan Kannan
  • Microbead-based test plates and test methods for fluorescence imaging systems
    Publication number: 20020098588
    Abstract: The present invention provides a test plate and methods for adjusting fluorescence imaging systems involving using a plate with fluorescent microbeads bound to a surface.
    Type: Application
    Filed: November 30, 2001
    Publication date: July 25, 2002
    Inventors: Paul Sammak, Gustavo Rosania, Lawrence J. Zana, Kim Ippolito, Jason Bush, Alex Friedman, Sarah Burroughs Tencza, Ravi Kapur