Patents by Inventor Guy Carrault
Guy Carrault has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11484272Abstract: The invention relates to an active implantable medical device comprising a processing unit able to be alternately operated during a predetermined period of activity and on standby during a standby period in a cyclical manner, and means for acquiring data relating to physiological and/or physical activity. The device also comprises means for calculating a frequency analysis of the data acquired, said calculating means being capable of successively perform part of the frequency analysis during periods of activity of the processing unit.Type: GrantFiled: September 30, 2016Date of Patent: November 1, 2022Assignees: SORIN CRM SAS, INSERM—INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE DE RENNES 1Inventors: Jean-Luc Bonnet, Thomas Herrmann, Christine Henry, Alfredo Hernandez, Guy Carrault
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Patent number: 11464458Abstract: The invention relates to a non-invasive system for determining the maturation of a baby, which comprises a module for sampling a cardiac or electroencephalographic signal from a baby and advantageously performs a conversion of a plurality of temporal samples derived from the cardiac signal or from the electroencephalic signal into a visibility graph, then a determination of at least one index on the basis of this visibility graph, a comparison of at least one determined index with one or more statistical indices representative of the maturation of a plurality of babies and a visual representation of a distance between at least one determined index and the statistical indices.Type: GrantFiled: September 5, 2018Date of Patent: October 11, 2022Assignees: UNIVERSITÉ DE RENNES 1, CHU DE RENNES, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM)Inventors: Guy Carrault, Nadine Khodor, Patrick Pladys, Mathieu Kuchenbuch
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Patent number: 11389656Abstract: An active implantable medical device for neurostimulation therapy is disclosed. The device produces stimulation pulse sequences generated continuously in succession during activity periods separated by intermediate inactivity periods during which no stimulation is issued. An input signal, provided by a physiological sensor, representative of cardiac activity and/or of the patient's hemodynamic status is received by circuitry. The circuitry further provides for dynamic control of the neurostimulation therapy, wherein the length of activity periods is modulated based on the current value level of the control parameter compared to a threshold. The duration of the next period of inactivity is calculated by the circuitry at the end of each activity period to maintain a constant duty cycle ratio between periods of activity and periods of inactivity.Type: GrantFiled: December 21, 2018Date of Patent: July 19, 2022Assignees: SORIN CRM SAS, UNIVERSI IÉ DE RENNES 1, INSERM—INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALEInventors: Jean-Luc Bonnet, Alfredo Hernandez, Guy Carrault, Hector Romero
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Publication number: 20200281487Abstract: The invention relates to a non-invasive system for determining the maturation of a baby, which comprises a module for sampling a cardiac or electroencephalographic signal from a baby and advantageously performs a conversion of a plurality of temporal samples derived from the cardiac signal or from the electroencephalic signal into a visibility graph, then a determination of at least one index on the basis of this visibility graph, a comparison of at least one determined index with one or more statistical indices representative of the maturation of a plurality of babies and a visual representation of a distance between at least one determined index and the statistical indices.Type: ApplicationFiled: September 5, 2018Publication date: September 10, 2020Inventors: Guy CARRAULT, Nadine KHODOR, Patrick PLADYS, Mathieu KUCHENBUCH
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Publication number: 20190126048Abstract: An active implantable medical device for neurostimulation therapy is disclosed. The device produces stimulation pulse sequences generated continuously in succession during activity periods separated by intermediate inactivity periods during which no stimulation is issued. An input signal, provided by a physiological sensor, representative of cardiac activity and/or of the patient's hemodynamic status is received by circuitry. The circuitry further provides for dynamic control of the neurostimulation therapy, wherein the length of activity periods is modulated based on the current value level of the control parameter compared to a threshold. The duration of the next period of inactivity is calculated by the circuitry at the end of each activity period to maintain a constant duty cycle ratio between periods of activity and periods of inactivity.Type: ApplicationFiled: December 21, 2018Publication date: May 2, 2019Applicants: SORIN CRM SAS, UNIVERSITÉ DE RENNES 1, INSERM - INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALEInventors: Jean-Luc Bonnet, Alfredo Hernandez, Guy Carrault, Hector Romero
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Patent number: 10166393Abstract: The invention relates to an active implantable medical device. The device includes a VNS pulse generator, an activity sensor for detecting a patient's current activity level, and a processor. The processor is configured to collect the electrical activity of the heart, such as a current intrinsic heart rate of the patient. The processor further calculates values of a reference heart rate based on the patient's current activity level. A first histogram is constructed from the reference heart rate values, and a second histogram is constructed from the intrinsic heart rate values. An index representative of the patient's condition is derived by comparing the first and second histograms.Type: GrantFiled: October 14, 2015Date of Patent: January 1, 2019Assignees: SORIN CRM SAS, UNIVERSITÉ DE RENNES 1Inventors: Jean-Luc Bonnet, Mélanie Mullemeester, Alfredo Hernandez, Guy Carrault
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Patent number: 10159840Abstract: An active implantable medical device for neurostimulation therapy is disclosed. The device produces stimulation pulse sequences generated continuously in succession during activity periods separated by intermediate inactivity periods during which no stimulation is issued. An input signal, provided by a physiological sensor, representative of cardiac activity and/or of the patient's hemodynamic status is received by circuitry. The circuitry further provides for dynamic control of the neurostimulation therapy, wherein the length of activity periods is modulated based on the current value level of the control parameter compared to a threshold. The duration of the next period of inactivity is calculated by the circuitry at the end of each activity period to maintain a constant duty cycle ratio between periods of activity and periods of inactivity.Type: GrantFiled: July 22, 2015Date of Patent: December 25, 2018Assignees: SORIN CRM SAS, UNIVERSITÉ DE RENNES 1, INSERM-INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALEInventors: Jean-Luc Bonnet, Alfredo Hernandez, Guy Carrault, Hector Romero
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Patent number: 10124173Abstract: One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to the rules on physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.Type: GrantFiled: June 28, 2016Date of Patent: November 13, 2018Assignees: SORIN CRM SAS, UNIVERSITE DE RENNES 1, INSERM- INSTITUT DE LA RECHERCHE MEDICALEInventors: Jean-Luc Bonnet, Alfredo Hernandez, Guy Carrault, Hector Romero, Virginie Le Rolle
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Patent number: 10099056Abstract: One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to the rules on physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.Type: GrantFiled: June 28, 2016Date of Patent: October 16, 2018Assignees: Sorin CRM SAS, UNIVERSITE DE RENNES 1, INSERM—INSTITUT DE LA RECHERCHE MEDICALEInventors: Jean-Luc Bonnet, Alfredo Hernandez, Guy Carrault, Hector Romero, Virginie Le Rolle
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Patent number: 10092756Abstract: One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to rules on the physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.Type: GrantFiled: June 28, 2016Date of Patent: October 9, 2018Assignees: SORIN CRM SAS, UNIVERSITE DE RENNES 1, INSERM—INSTITUT DE LA RECHERCHE MEDICALEInventors: Jean-Luc Bonnet, Alfredo Hernandez, Guy Carrault, Hector Romero, Virginie Le Rolle
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Publication number: 20180271452Abstract: The invention relates to an active implantable medical device comprising a processing unit able to be alternately operated during a predetermined period of activity and on standby during a standby period in a cyclical manner, and means for acquiring data relating to physiological and/or physical activity. The device also comprises means for calculating a frequency analysis of the data acquired, said calculating means being capable of successively perform part of the frequency analysis during periods of activity of the processing unit.Type: ApplicationFiled: September 30, 2016Publication date: September 27, 2018Inventors: Jean-Luc Bonnet, Thomas Herrmann, Christine Henry, Alfredo Hernandez, Guy Carrault
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Patent number: 9981132Abstract: One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to the rules on physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.Type: GrantFiled: June 28, 2016Date of Patent: May 29, 2018Assignees: SORIN CRM SAS, UNIVERSITE DE RENNES 1, INSERM—INSTITUT DE LA RECHERCHE MEDICALEInventors: Jean-Luc Bonnet, Alfredo Hernandez, Guy Carrault, Hector Romero, Virginie Le Rolle
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Patent number: 9681815Abstract: The present invention relates to an active medical device that uses non-linear filtering for reconstructing a surface electrocardiogram from an endocardial electrogram. At least one endocardial EGM electrogram signal is collected from of samples collected from at least one endocardial or epicardial derivation (71?, 72?, 73?), and at least one of a reconstructed surface electrocardiogram (ECG) signal through the processing of collected EGM samples by a transfer function (TF) of a neural network (60?). The neural network (60?) is a time-delay-type network that simultaneously processes said at least one endocardial EGM electrogram signal, formed by a first sequence of collected samples, and at least one delayed version of this EGM signal, formed by a second sequence of collected samples distinct from the first sequence collected samples. The neural network (60?) provides said reconstructed ECG signal from the EGM signal and its delayed version.Type: GrantFiled: August 30, 2013Date of Patent: June 20, 2017Assignee: SORIN CRM SASInventors: Fabienne Porée, Guy Carrault, Amar Kachenoura, Alfredo Hernandez
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Publication number: 20160375252Abstract: One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to the rules on physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.Type: ApplicationFiled: June 28, 2016Publication date: December 29, 2016Inventors: Jean-Luc BONNET, Alfredo HERNANDEZ, Guy CARRAULT, Hector ROMERO, Virginie LE ROLLE
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Publication number: 20160375250Abstract: One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to the rules on physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.Type: ApplicationFiled: June 28, 2016Publication date: December 29, 2016Inventors: Jean-Luc BONNET, Alfredo HERNANDEZ, Guy CARRAULT, Hector ROMERO, Virginie LE ROLLE
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Publication number: 20160375249Abstract: One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to rules on the physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.Type: ApplicationFiled: June 28, 2016Publication date: December 29, 2016Inventors: Jean-Luc BONNET, Alfredo HERNANDEZ, Guy CARRAULT, Hector ROMERO, Virginie LE ROLLE
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Publication number: 20160375251Abstract: One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to the rules on physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.Type: ApplicationFiled: June 28, 2016Publication date: December 29, 2016Inventors: Jean-Luc BONNET, Alfredo HERNANDEZ, Guy CARRAULT, Hector ROMERO, Virginie LE ROLLE
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Publication number: 20160136428Abstract: The invention relates to an active implantable medical device. The device includes a VNS pulse generator, an activity sensor for detecting a patient's current activity level, and a processor. The processor is configured to collect the electrical activity of the heart, such as a current intrinsic heart rate of the patient. The processor further calculates values of a reference heart rate based on the patient's current activity level. A first histogram is constructed from the reference heart rate values, and a second histogram is constructed from the intrinsic heart rate values. An index representative of the patient's condition is derived by comparing the first and second histograms.Type: ApplicationFiled: October 14, 2015Publication date: May 19, 2016Inventors: Jean-Luc Bonnet, Mélanie Mullemeester, Alfredo Hernandez, Guy Carrault
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Publication number: 20160022997Abstract: An active implantable medical device for neurostimulation therapy is disclosed. The device produces stimulation pulse sequences generated continuously in succession during activity periods separated by intermediate inactivity periods during which no stimulation is issued. An input signal, provided by a physiological sensor, representative of cardiac activity and/or of the patient's hemodynamic status is received by circuitry. The circuitry further provides for dynamic control of the neurostimulation therapy, wherein the length of activity periods is modulated based on the current value level of the control parameter compared to a threshold. The duration of the next period of inactivity is calculated by the circuitry at the end of each activity period to maintain a constant duty cycle ratio between periods of activity and periods of inactivity.Type: ApplicationFiled: July 22, 2015Publication date: January 28, 2016Inventors: Jean-Luc Bonnet, Alfredo Hernandez, Guy Carrault, Hector Romero
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Publication number: 20130345580Abstract: The present invention relates to an active medical device that uses non-linear filtering for reconstructing a surface electrocardiogram from an endocardial electrogram. At least one endocardial EGM electrogram signal is collected from of samples collected from at least one endocardial or epicardial derivation (71?, 72?, 73?), and at least one of a reconstructed surface electrocardiogram (ECG) signal through the processing of collected EGM samples by a transfer function (TF) of a neural network (60?). The neural network (60?) is a time-delay-type network that simultaneously processes said at least one endocardial EGM electrogram signal, formed by a first sequence of collected samples, and at least one delayed version of this EGM signal, formed by a second sequence of collected samples distinct from the first sequence collected samples. The neural network (60?) provides said reconstructed ECG signal from the EGM signal and its delayed version.Type: ApplicationFiled: August 30, 2013Publication date: December 26, 2013Applicant: Sorin CRM S.A.S.Inventors: Fabienne Porée, Guy Carrault, Amar Kachenoura, Alfredo Hernandez