Abstract: A network element is configured to efficiently load balance packets through a computer network. The network element receives a packet associated with flow attributes and generates a Load Balancing Flow Vector (LBFV) from the flow attributes. The network element partitions the LBFV into a plurality of LBFV blocks and reorders the LBFV blocks to generate a reordered LBFV. The LBFV blocks are reordered based on a reordering sequence that is different from reordering sequences on other network elements in the computer network. The network element hashes the reordered LBFV to generate a hash key for the packet and selects a next hop link based on the hash key. The next hop link connects the network elements to a next hop network element in the computer network.

Abstract: Provided in some aspects are compositions of cells for treating subjects with disease and conditions such as non-Hodgkin's lymphoma (NHL), and related methods, compositions, uses and articles of manufacture. In some embodiments, the disease or condition is a B-cell non-Hodgkin lymphoma (B-cell NHL). The cells generally express recombinant receptors such as chimeric antigen receptors (CARs) for targeting an antigen, such as CD 19, on cells of the lymphoma.

Abstract: Provided in some aspects are compositions of cells for treating subjects with disease and conditions such as multiple myeloma (MM), and related methods, compositions, uses and articles of manufacture. In some embodiments, the disease or condition is a relapsed or refractory multiple myeloma (r/r MM). The cells generally express recombinant receptors such as chimeric antigen receptors (CARs) for targeting an antigen, such as BCMA, on cells of the myeloma.

Abstract: A network element is configured to efficiently load balance packets through a computer network. The network element receives a packet associated with flow attributes and generates a Load Balancing Flow Vector (LBFV) from the flow attributes. The network element partitions the LBFV into a plurality of LBFV blocks and reorders the LBFV blocks to generate a reordered LBFV. The LBFV blocks are reordered based on a reordering sequence that is different from reordering sequences on other network elements in the computer network. The network element hashes the reordered LBFV to generate a hash key for the packet and selects a next hop link based on the hash key. The next hop link connects the network elements to a next hop network element in the computer network.

Abstract: A network element is configured to efficiently load balance packets through a computer network. The network element receives a packet associated with flow attributes and generates a Load Balancing Flow Vector (LBFV) from the flow attributes. The network element partitions the LBFV into a plurality of LBFV blocks and reorders the LBFV blocks to generate a reordered LBFV. The LBFV blocks are reordered based on a reordering sequence that is different from reordering sequences on other network elements in the computer network. The network element hashes the reordered LBFV to generate a hash key for the packet and selects a next hop link based on the hash key. The next hop link connects the network elements to a next hop network element in the computer network.

Abstract: The present disclosure provides processes for genetically engineering T cells, such as primary CD4+ T cells and/or CD8+ T cells, for use in cell therapy that does not involve expanding the cells. In particular aspects, the provided processes successfully generate compositions of engineered T cells, such as containing populations of engineered T cells, that express a chimeric antigen receptor (CAR) within a shortened amount of time as compared to alternative engineering processes, such as processes that involve expanding the cells. In certain aspects, the provided processes successfully generate a composition of engineered T cells suitable for use in cell therapy within 4 days from when the process to stimulate or activate the cells is initiated.

Abstract: Disclosed are various embodiments of configurable allocation of hardware resources. In one embodiment, a processing device includes a configurable communication grid including a plurality of crossbars interconnected by intercommunication paths in a geometric configuration and a plurality of pipeline elements distributed within the configurable communication grid. Each crossbar is designed to direct communications received at an input to a selected output. Each pipeline element is communicatively coupled to an output of a first crossbar adjacent to the pipeline element and an input of a second crossbar adjacent to the pipeline element. In another embodiment, a process matrix includes a plurality of pipeline elements interconnected by a configurable communication grid. The configurable communication grid includes intercommunication paths connecting crossbars in a geometric configuration.

Abstract: The present invention relates to compositions and methods for making recombinant heteromeric proteins using a protein complementation assay employing complementation pairs of selectable markers.