Abstract: The present invention relates to a radiolabeled DNA carrier, a method of preparation thereof and the therapeutic uses of this substance to prevent uncontrolled cellular proliferation. The invention also relates to devices incorporating the above radiolabeled DNA carrier (such as an oligonucleotide) for the therapeutic treatment of uncontrolled cellular proliferation. More specifically, the present invention is concerned with the prevention of restenosis by intravascular delivery of radiolabeled DNA carrier at a dilatation site of an artery. This invention is also directed to a method of treatment of vascular proliferative diseases and/or other proliferative disorders such as cancer and related metastasis.

Abstract: The present invention relates to an occlusion device for treating an aneurysm, its use and a method for treating an aneurysm. The occlusion device comprises a detachable filling element and at least one radioactive source. The detachable filling element and the radioactive source are adapted to be inserted into a vessel at least in close proximity of a neck of an aneurysm. The radioactive source stimulates neointima formation for obstructing the neck of the aneurysm or filling up the aneurysm.

Abstract: The invention relates to a method for the sustained endovascular treatment of aneurysms, such as intracranial or for closing any body lumen, such as vascular lumen or other using an occlusion device for the local delivery of biologically active DNA therapeutic molecules. The invention also relates to a method for a rapid preparation of the artificial occlusion device to be coated shortly before or during the clinical procedure. A subsequent step in the method of treatment involves introducing at an aneurysm site or inside a vessel a slow-releasing, biologically active DNA molecule-leaching device. The device releases a biologically active DNA molecule at the aneurysm site for stimulating neointima formation and for increasing neointima thickness. The neointima formation fills the aneurysm and the biologically active DNA molecule released in the aneurysm is absorbed by surrounding tissues of the aneurysm for providing long-term treatment of the aneurysm preventing recanalisation.

Abstract: The present invention relates to a device and method for delivering locally therapeutic agents within adjacent tissues such as an arterial wall for treating vascular diseases. The device comprises i) an endovascular device, ii) an hydrophobic linker molecule containing a diazonium moiety electrodeposited onto the surface of the endovascular device, and iii) a lipophilic drug passively deposited on the linker molecule, said drug binding to the linker molecule through hydrophobic interactions for elution from the endovascular device over time. The present invention also relates to a method for preparing such device.

Abstract: The present invention relates to the cloning of human pro-protein converting enzyme 5 (PC5) CDNA isolated from human adrenal gland messenger RNA. Additionally, this invention relates to a method for reducing restenosis occurring at an injured vascular site comprising delivering to the injured site an antisense nucleic acid to suppress the expression of human PC5.

Abstract: The present invention relates to a radiolabeled DNA oligonucleotide, a method of preparation thereof and the therapeutic uses of this substance to prevent uncontrolled cellular proliferation. The invention also relates to devices incorporating the above radiolabeled DNA oligonucleotide for the therapeutic treatment of uncontrolled cellular proliferation. More specifically, the present invention is concerned with the prevention of restenosis by coronary delivery of radiolabeled DNA oligonucleotide at a dilatation site of an artery. This invention is also directed to a method of treatment of vascular proliferative diseases and/or other proliferative disorders such as cancer and related metastasis.

Abstract: An electrical switching device is disclosed, which is particularly well adapted for use in a hold-up alarm system. The device comprises a casing having a longitudinal axis and two lateral openings symmetrically positioned with respect to the longitudinal axis and a push-button switch centrally mounted inside the casing, and having an actuating push-button coaxial to the casing. The push-button switch is connected in series with an electrical circuit so that this circuit is switched on or off when the button is pressed. The device also comprises a flexible blade extending transversally inside the casing, the blade having a central portion adjacent to the push button and two opposite ends; and manually operable device for squeezing the blade in such a manner as to cause it to bend and press onto the push button to activate the switch.

Abstract: A check valve for removably fitting the mouth of an invertible water bottle to be placed on a water dispenser, the bottle being made of synthetic resin and provided with an external circular rib at its mouth. The valve closes the mouth during water-bottle inversion until the check valve contacts an element of the water dispenser when the bottle is in inverted position and rests on a water dispenser. The check valve includes a cylindrical body adapted to be removably fitted over the water bottle mouth and having an outer closure wall provided with a central opening forming a tapered female valve seat. The check valve further includes a male valve member part having a disc-like head axially movable within the body between the mouth and the closure wall, a stem secured to the head and extending through the central opening of the closure wall, and a tapered male valve seat portion integral with the stem and adjacent the head.