Abstract: Described herein are method of generating and uses of polypeptides with dual binding specificity, wherein the polypeptides contain a first binding-site for a first antigen and a second binding-site for a second antigen. The second binding-site comprises amino acid variants of native amino acid sequences of polypeptides that bind to the first antigen, wherein the variants do not abrogate binding to said first antigen. In one embodiment, polypeptides with dual binding specificity to PD1 and OX40 are disclosed herein. In another embodiment, polypeptides with dual binding specificity to PD1 and GITR are disclosed herein.

Abstract: Described herein are engineered anti-IL-2 antibodies with modified amino acid sequences. The engineered antibodies would confer modified receptor binding specificity to an IL-2-anti-IL2 antibody complex, inhibiting the binding of IL-2 to CD25. The engineered anti-IL-2 antibodies would facilitate expansion of subsets of effector immune cells and decrease undesirable effects caused by IL-2. Thus, the engineered anti-IL-2 antibodies would be useful in treating disease such as cancer and infection.

Abstract: According to embodiments of the present invention, there is provided a device for prevention of card displacement. The device includes a holding element at least partially formed of electrically conductive material; a board including an electric circuit, an alarm element and a power source that is operatively associated with the electric circuit and the alarm element. The holding element is coupled to the board such that at least some of the electrically conducting material of the holding element is pressed by default against the board, such that adjustment of a card between the holding element and the board opens the electric circuit and wherein removal of the card therefrom closes the electric circuit and thereby activates the alarm element.

Abstract: A device, system and method for transmitting a signal that controls a function of a cellular telephone from a key pad mounted on a steering wheel, and displaying an indication of such signal on a screen in front of a driver.

Abstract: A device, system and method for transmitting a signal that controls a function of a cellular telephone from a key pad mounted on a steering wheel, and displaying an indication of such signal on a screen in front of a driver.