Abstract: A biodegradable single-phase cohesive hydrogel includes a homogenous mixture of 2 to 5 identical or different polymers interpenetrating each other in a single phase, wherein the polymers are independently crosslinked prior to interpenetration by mixing, and the crosslinked polymers are insoluble in water and miscible with each other.

Abstract: A sterilized aqueous composition includes at least one hyaluronic acid or salt thereof and at least mepivacaine or salt thereof. The weight ratio between the concentration of hyaluronic acid [HA] and the concentration of mepivacaine [MEPI]-[HA]/[MEPI]- is no lower than 0.1. Mepivacaine may be used as a substitute for lidocaine in an equivalent amount in order to obtain a hyaluronic acid composition including a local anaesthetic with rheological properties after heat sterilization that are superior to the rheological properties of the same composition of hyaluronic acid except including lidocaine.

Abstract: A biodegradable single-phase cohesive hydrogel includes a homogenous mixture of 2 to 5 identical or different polymers interpenetrating each other in a single phase, wherein the polymers are independently crosslinked prior to interpenetration by mixing, and the crosslinked polymers are insoluble in water and miscible with each other.

Abstract: A process of preparing a biodegradable single-phase cohesive hydrogel composition includes preparing 2 to 5 hydrogels that are independently crosslinked so that each hydrogel has a degree of crosslinking in a range from 0.02 to 0.4, and mixing the 2 to 5 hydrogels to obtain a homogenous mixture of 2 to 5 intertwined hydrogels that interpenetrate each other to form a single phase without covalent bonding between the hydrogels, wherein each hydrogel is prepared by a process that comprises independently crosslinking a polymer and the total polymer concentration of the composition is in a range from 5 to 50 mg/g.

Abstract: An injectable sterilized aqueous composition including at least one hyaluronic acid, at least one polyol and at least one local anesthetic chosen from the group made of benzocaine, chloroprocaine, procaine, etidocaine, aptocaine, chlorobutanol, diamocaine, dyclonine, guafecainol, polidocanol, mepivacaine, prilocaine, articaine, bupivacaine, ropivacaine, tetracaine and salts thereof and isolated isomers thereof. The invention also relates to a process for adapting the rheological properties of a heat sterilized injectable aqueous composition. The invention also relates to a process for producing an injectable sterilized aqueous composition according to the invention, and also to uses of said injectable sterilized aqueous composition according to the invention.

Abstract: An injectable sterilized aqueous composition including at least one hyaluronic acid, at least one polyol and at least one local anesthetic chosen from the group made of benzocaine, chloroprocaine, procaine, etidocaine, aptocaine, chlorobutanol, diamocaine, dyclonine, guafecainol, polidocanol, mepivacaine, prilocaine, articaine, bupivacaine, ropivacaine, tetracaine and salts thereof and isolated isomers thereof. The invention also relates to a process for adapting the rheological properties of a heat sterilized injectable aqueous composition. The invention also relates to a process for producing an injectable sterilized aqueous composition according to the invention, and also to uses of said injectable sterilized aqueous composition according to the invention.

Abstract: Biodegradable single-phase cohesive hydrogels useful, e.g., for the formulation of viscosupplementation compositions or compositions for filling wrinkles, contain a homogeneous blend of x polymers, which may be identical or different, crosslinked prior to the interpenetration thereof by mixing in the form of a single-phase hydrogel, wherein such crosslinked polymers are insoluble in water and miscible with one another, and x ranges from 2 to 5; in one embodiment, the hydrogels are such that the x polymers have identical or different degrees of crosslinking, at least one of the x polymers having a degree of crosslinking x1 and at least one of the x polymers having a degree of crosslinking x2, with x1 being greater than or equal to x2.

Abstract: A process of preparing a biodegradable single-phase cohesive hydrogel composition includes preparing 2 to 5 hydrogels that are independently crosslinked so that each hydrogel has a degree of crosslinking in a range from 0.02 to 0.4, and mixing the 2 to 5 hydrogels to obtain a homogenous mixture of 2 to 5 intertwined hydrogels that interpenetrate each other to form a single phase without covalent bonding between the hydrogels, wherein each hydrogel is prepared by a process that comprises independently crosslinking a polymer and the total polymer concentration of the composition is in a range from 5 to 50 mg/g.

Abstract: A sterilized aqueous composition includes at least one hyaluronic acid or salt thereof and at least mepivacaine or salt thereof. The weight ratio between the concentration of hyaluronic acid [HA] and the concentration of mepivacaine [MEPI]—[HA]/[MEPI]—is no lower than 0.1. Mepivacaine may be used as a substitute for lidocaine in an equivalent amount in order to obtain a hyaluronic acid composition including a local anaesthetic with rheological properties after heat sterilization that are superior to the rheological properties of the same composition of hyaluronic acid except including lidocaine.

Abstract: An injectable sterilized aqueous composition including at least one hyaluronic acid, at least one polyol and at least one local anesthetic chosen from the group made of benzocaine, chloroprocaine, procaine, etidocaine, aptocaine, chlorobutanol, diamocaine, dyclonine, guafecainol, polidocanol, mepivacaine, prilocaine, articaine, bupivacaine, ropivacaine, tetracaine and salts thereof and isolated isomers thereof. The invention also relates to a process for adapting the rheological properties of a heat sterilized injectable aqueous composition. The invention also relates to a process for producing an injectable sterilized aqueous composition according to the invention, and also to uses of said injectable sterilized aqueous composition according to the invention.

Abstract: Biodegradable single-phase cohesive hydrogels useful, e.g., for the formulation of viscosupplementation compositions or compositions for filling wrinkles, contain a homogeneous blend of x polymers, which may be identical or different, crosslinked prior to the interpenetration thereof by mixing in the form of a single-phase hydrogel, wherein such crosslinked polymers are insoluble in water and miscible with one another, and x ranges from 2 to 5; in one embodiment, the hydrogels are such that the x polymers have identical or different degrees of crosslinking, at least one of the x polymers having a degree of crosslinking x1 and at least one of the x polymers having a degree of crosslinking x2, with x1 being greater than or equal to x2.

Abstract: Biodegradable single-phase cohesive hydrogels useful, e.g., for the formulation of viscosupplementation compositions or compositions for filling wrinkles, contain a homogeneous blend of x polymers, which may be identical or different, crosslinked prior to the interpenetration thereof by mixing in the form of a single-phase hydrogel, wherein such crosslinked polymers are insoluble in water and miscible with one another, and x ranges from 2 to 5; in one embodiment, the hydrogels are such that the x polymers have identical or different degrees of crosslinking, at least one of the x polymers having a degree of crosslinking x1 and at least one of the x polymers having a degree of crosslinking x2, with x1 being greater than or equal to x2.

Abstract: The invention relates to a folding device for folding intraocular implants having flexible optical portions. Said device comprises two folding element facing each other and whose ends are connected together by deformable means. Each folding element comprises a body and a jaw projecting from said body, an elastically deformable support projecting from said body in the direction in which the two elements are brought together, a positioning stud projecting from said second end of the support perpendicularly to said support and facing upwards so as to co-operate, at rest, with the periphery of the optical portion of the implant, and an extension projecting from said body in the direction in which the two elements are brought together, and having a ramp suitable for co-operating with the support on the other folding element while the two folding elements are being brought together to cause said positioning stud to be lowered.

Abstract: The invention relates to an injector device for injecting an intraocular implant into the eye of a patient, which device comprises a folding chamber for folding the optical portion of the implant, a folding member, a hollow needle for injecting the folded implant into the eye, said hollow needle opening out at a first end of said chamber, a guide channel opening out at the second end of said chamber, and a moving piston mounted in said guide channel so as to push said folded implant into said hollow needle.

Abstract: The invention relates to a folding device for folding intraocular implants having flexible optical portions. Said device comprises two folding element facing each other and whose ends are connected together by deformable means. Each folding element comprises a body and a jaw projecting from said body, an elastically deformable support projecting from said body in the direction in which the two elements are brought together, a positioning stud projecting from said second end of the support perpendicularly to said support and facing upwards so as to co-operate, at rest, with the periphery of the optical portion of the implant, and an extension projecting from said body in the direction in which the two elements are brought together, and having a ramp suitable for co-operating with the support on the other folding element while the two folding elements are being brought together to cause said positioning stud to be lowered.

Abstract: The invention relates to an injector device for injecting an intraocular implant into the eye of a patient, which device comprises a folding chamber for folding the optical portion of the implant, a folding member, a hollow needle for injecting the folded implant into the eye, said hollow needle opening out at a first end of said chamber, a guide channel opening out at the second end of said chamber, and a moving piston mounted in said guide channel so as to push said folded implant into said hollow needle.