Patents by Inventor György Hutvágner

György Hutvágner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions for RNA interference and methods of use thereof
    Patent number: 8729036
    Abstract: The present invention provides compositions for RNA interference and methods of use thereof. In particular, the invention provides single-stranded small interfering RNAs. Functional and genomic and proteomic methods are featured. Therapeutic methods are also featured.
    Type: Grant
    Filed: August 7, 2003
    Date of Patent: May 20, 2014
    Assignee: University of Massachusetts
    Inventors: Phillip D. Zamore, György Hutvágner, Dianne Schwarz, Guiliang Tang, Benjamin Haley
  • Sequence-specific inhibition of small RNA function
    Patent number: 8685946
    Abstract: The present invention relates to the discovery of a method for inhibiting RNA silencing in a target sequence-specific manner. RNA silencing requires a set of conserved cellular factors to suppress expression of gene-encoded polypeptide. The invention provides compositions for sequence-specific inactivation of the RISC component of the RNA silencing pathway, and methods of use thereof. The RISC inactivators of the present invention enable a variety of methods for identifying and characterizing miRNAs and siRNAs, RISC-associated factors, and agents capable of modulating RNA silencing. Therapeutic methods and compositions incorporating RISC inactivators and therapeutic agents identified through use of RISC inactivators are also featured.
    Type: Grant
    Filed: November 26, 2004
    Date of Patent: April 1, 2014
    Assignee: Universiy of Massachusetts
    Inventors: György Hutvágner, Phillip D. Zamore
  • In vivo production of small interfering RNAs that mediate gene silencing
    Patent number: 7893036
    Abstract: The invention provides engineered RNA precursors that when expressed in a cell are processed by the cell to produce targeted small interfering RNAs (siRNAs) that selectively silence targeted genes (by cleaving specific mRNAs) using the cell's own RNA interference (RNAi) pathway. By introducing nucleic acid molecules that encode these engineered RNA precursors into cells in vivo with appropriate regulatory sequences, expression of the engineered RNA precursors can be selectively controlled both temporally and spatially, i.e., at particular times and/or in particular tissues, organs, or cells.
    Type: Grant
    Filed: March 26, 2008
    Date of Patent: February 22, 2011
    Assignee: University of Massachusetts
    Inventors: Phillip D. Zamore, Juanita McLachlan, Gyoergy Hutvagner, Alla Grishok, Craig C. Mello
  • Methods and compositions for enhancing the efficacy and specificity of RNA silencing
    Patent number: 7750144
    Abstract: The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.
    Type: Grant
    Filed: August 4, 2004
    Date of Patent: July 6, 2010
    Assignee: University of Massachusetts
    Inventors: Phillip D. Zamore, György Hutvágner, Dianne Schwarz, Martin Simard