Patents by Inventor Gyorgy Lugosi
Gyorgy Lugosi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 4960913Abstract: The invention relates to a process for the preparation of tetracycline derivatives of the formula ##STR1## and acid addition salts thereof --wherein R stands for --CH.sub.3 or .dbd.CH.sub.2 --by dehalogenating and hydrogenating chloromethacycline or acid addition salt thereof of the formula ##STR2## or by hydrating methacycline or acid addition salts thereof of the formula ##STR3## by treatment with hydrogen gas in the presence of a noble metal alloy catalyst on carrier and organic solvent which comprises performing, hydrogenating under pressure of 0.1-1.0 MPa with an alloy catalyst consisting of the alloy palladium or platinum and selenium and/or tellurium used at a ratio of 1:0.01-0.5 related to the amount of the starting tetracycline and carrying out, if desired dehalogenation and hydrogenation in one step.Type: GrantFiled: May 5, 1989Date of Patent: October 2, 1990Assignee: Chinoin Gyogyszer- es Vegyeszeti Termekek Gyara Rt.Inventors: Erzsebet Szalay, Gyorgy Lugosi, Tamas U. Kallay, Zsuzsanna Nad, Istvan Jelinek, Vilmos Simonidesz, Peter Gyory, Lajos Nagy, Marta Lugosi, Ilona Santa nee Singola, Gabor Besenyei, Laszlo Simandi
-
Patent number: 4675413Abstract: A new process is disclosed for preparing a compound of the formula (I) ##STR1## wherein R is C.sub.1 to C.sub.5 alkyl; which comprises reducing a compound of the formula (II) ##STR2## or salt thereof wherein A is --SO.sub.2 X, --SOH, --SOA.sup.1, or --SA.sup.1 group,X is chlorine or hydrogen; andA.sup.1 is a group of the Formula ##STR3## with the aid of aluminum activated with a catalytic amount of a metal and/or metal salt in a mixture of water, a mineral acid, and an aliphatic carboxylic acid having 1 to 3 carbon atoms at a temperature of 0.degree. to 100.degree. C., thereafter, optionally, the product is recovered from an acid medium at a pH range of 2 to 3 in crystalline form.Type: GrantFiled: December 19, 1985Date of Patent: June 23, 1987Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara rtInventors: Maria Bakonyi, Gyorgy Lugosi, Tamas Kallai, Maria Hima nee Toth, Tibor Montai, Maria Sziladi
-
Patent number: 4659515Abstract: The invention relates to a new and improved process for the preparation of 6-demethyl-6-deoxy-6-methylene-5-oxytetracycline and the 11a-chloro derivative thereof by dehydrating 11a-chloro-5-oxytetracycline-6,12-hemiketal, which comprises treating 11a-chloro-5-oxytetracycline-6,12-hemiketal or an acid salt thereof with a dehydrating mixture formed by the reaction of chloro sulfonic acid and formic acid and isolating the 11a-chloro-6-demethyl-6-deoxy-6-methylene-5-oxytetracycline and salt thus obtained and optionally dehalogenating the same by reaction with a reducing agent.The advantage of the process of the present invention is that it is simple, economical and suitable for industrial scale manufacture and provides a pure product of high quality by excellent yields.Type: GrantFiled: August 31, 1984Date of Patent: April 21, 1987Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RtInventors: Gyorgy Lugosi, Maria Hima nee Toth, Maria Bakonyi, Sandor Szoke
-
Patent number: 4435567Abstract: A process for the preparation of substituted urea derivatives, and compositions and concentrates for the same purpose are disclosed. According to the process the substituted urea derivatives of formula (I) ##STR1## wherein R is hydrogen, alkyl, aryl, cycloalkyl or aralkyl, R.sup.1 and R.sup.2 are hydrogen, alkyl, alkenyl, alkinyl, alkoxy, oxyalkyl, cycloalkyl, aralkyl, alkoxycarbonylalkyl, aryl or heteroaryl, or R.sup.1 and R.sup.Type: GrantFiled: December 28, 1981Date of Patent: March 6, 1984Assignee: Chinoin Gyogyszer es Vesgyeszeti Termekek Gyara R. T.Inventors: Gyorgy Lugosi, Antal Simay, Janos Bodnar, Laszlo Simandi, Eva Somfai
-
Patent number: 4368328Abstract: The invention concerns a new process for the preparation of biologically active 2-[(alkoxycarbonyl)amino]-5-(alkylthio)-1H-benzimidazoles of the general formula (V) ##STR1## wherein R and R.sup.1 independently stand for alkyl having 1 to 3 carbon atoms.Type: GrantFiled: December 3, 1980Date of Patent: January 11, 1983Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Sandor Szoke, Gyorgy Lugosi, Maria Bakonyi, Jeno Ghyczy, Gyorgy Csermely
-
Patent number: 4323469Abstract: The invention relates to a process for the preparation of carbamic acid phenyl esters of the formula (I) ##STR1## by acylating phenol derivatives of the formula (II) ##STR2## wherein R is alkyl having 1 to 8 carbon atoms, aryl, cycloalkyl having 5 or 6 carbon atoms, aralkyl having 7 to 16 carbon atoms which groups can be substituted by one or more alkyl groups,R.sup.1 is hydrogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms or acylamino,R.sup.2 is hydrogen, halogen, alkyl having 1 to 4 carbon atoms or alkoxy having 1 to 4 carbon atoms, or ifR.sup.1 and R.sup.2 represent alkyl and/or alkoxy, they can form together a carbocyclic ring.According to the invention the phenol derivatives of the general formula (II), wherein R.sup.1 and R.sup.2 are as defined above, are reacted with N-carbamoyl-saccharin derivatives of the formula (IV) ##STR3## wherein R has the same meaning as defined above, in the presence of a base.Type: GrantFiled: October 28, 1980Date of Patent: April 6, 1982Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.Inventors: Gyorgy Lugosi, Antal S. May, Janos Bodnar, Istvan Turcsan, Istvan Jelinek, Eva Somfai, Laszlo Simandi
-
Patent number: 4315861Abstract: A process is disclosed for preparing a carbamic acid phenyl ester of the formula (I) ##STR1## wherein R is alkyl having 1 to 8 carbon atoms, aryl, cycloalkyl having 5 or 6 carbon atoms, or aralkyl having 7 to 16 carbon atoms, wherein the aryl, cycloalkyl or aralkyl is unsubstituted or substituted by at least one alkyl group having 1 to 8 carbon atoms;R.sub.1 is hydrogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, cyanomethyl, 1,3-dioxolan-2-yl, or carboalkoxyamino wherein the alkoxy group contains 1 to 4 carbon atoms;R.sub.2 is hydrogen, halogen, alkyl having 1 to 4 carbon atoms or alkoxy having 1 to 4 carbon atoms; orR.sub.1 and R.sub.2 form together a carbocyclic ring or a heterocyclic ring fused to the phenyl ring wherein the carbocyclic ring of the heterocyclic ring is unsubstituted or substituted by at least one alkyl having 1 to 8 carbon atoms, which comprises acylating a phenol of the formula (II) ##STR2## with a compound of the formula (IV) ##STR3## in the presence of a base.Type: GrantFiled: March 23, 1981Date of Patent: February 16, 1982Assignee: Chinoin Gyogyszer RTInventors: Gyorgy Lugosi, Antal Simay, Janos Bodnar, Istvan Turcsan, Istvan Jelinek, Eva Somfai, Laszlo Simandi
-
Patent number: 4239653Abstract: The present invention relates to a process for the preparation of non-pyrophoric catalyst having controlledparticle size and activity comprising suspending active charcoal of homogeneous pore distribution in a diluted solution of a palladium salt or salt complex, if desired in the presence of an aliphatic alcohol, stirring the solution, filtering the catalyst coal, followed by treatment of the sorbed palladium salt or salt complex with alkali if desired and stirring it as long as required for the accumulation of the sorbed palladium compounds, reducing same by methods known, repeating the above mentioned steps, if desired any number of times and drying the obtained catalyst after washing.Type: GrantFiled: November 27, 1978Date of Patent: December 16, 1980Assignee: Chinoin GyogyszerInventors: Janos Bodnar, Gyorgy Lugosi, Gyorgy L. Nagy
-
Patent number: 4058608Abstract: The invention relates to a method of combatting phytopathogenic fungi, primarily powdery mildew. The method involves administering compositions according to the invention which contain as active principle at least one compound of the formula (I), ##STR1## wherein R.sup.1 is a C.sub.1-12 alkyl or a chloroethyl group,R.sup.2 is hydrogen, halogen, a C.sub.1-4 alkyl, a C.sub.1-4 alkoxy or nitro group,R.sup.3 is hydrogen, halogen, a C.sub.1-4 alkyl or nitro group, andR.sup.4 is hydrogen, halogen, a C.sub.1-4 alkyl or nitro group, or an acid addition salt thereof.Type: GrantFiled: October 20, 1975Date of Patent: November 15, 1977Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RTInventors: Tibor Zsolnai, Gyorgy Lugosi, Istvan Szepesi, Maria Bakonyi, Istvan Racz, Erzsebet Radvany nee Hegedus
-
Patent number: 3978217Abstract: Compounds of the formula, ##SPC1##WhereinR.sup.1 and R.sup.2 each stand for hydrogen or a group of the generalformula --(CH.sub.2).sub.n --SO.sub.3 H,n is an integer between 1 and 5, andR.sup.3 stands for an alkyl group,As well as the salts and quaternary salts thereof have been prepared by various methods. The new compounds according to the invention possess valuable fungicidal and/or ovicidal properties, and can be used as active ingredients of plantbiological compositions, cosmetics and pharmaceuticals, respectively.Type: GrantFiled: January 30, 1975Date of Patent: August 31, 1976Assignee: Chinoin Gyogyszer-es Vegyeszeti Termekek Gyara RTInventors: Sandor Szoke, Gyorgy Lugosi, Gyorgy Csermely, Maria Bakonyi, Tibor Zsolnai, Istvan Szepessy