Patents by Inventor Gyula Dalmadi

Gyula Dalmadi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the stereoselective reduction of &agr;,&bgr;-unsaturated ketones
    Patent number: 6482959
    Abstract: A process for the preparation of &agr;,&bgr;-unsaturated alcohols of general formula (I), wherein R means an alkyl group of 1-4 carbon atoms, or benzoyloxy group optionally substituted with a phenyl group; R1 means a hydrogen atom or an alkyl group of 1-4 carbon atoms, R2 means a hydrogen atom or an alkyl group of 1-4 carbon atoms; R3 means an alkyl group of 1-6 carbon atoms optionally substituted by phenyl group or cycloalkyl group of 5-7 carbon atoms; or a phenoxy group optionally substituted by a halogen atom, or a cycloalkyl group of 5-7 carbon atoms; R4 means a hydrogen atom or a halogen atom whereby at &agr;,&bgr;-unsaturated ketones of general formula (II) wherein the meanings of R, R1, R2, R3, and R4 are as given above—is diastereoselectively reduced with a borohydride type compound in an aprotic solvent, in the presence of an inorganic substance dissolublein the reaction mixture and having particle size from 0.
    Type: Grant
    Filed: June 27, 2000
    Date of Patent: November 19, 2002
    Assignee: Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt.
    Inventors: Kardos Zsuzsanna Baloghne, Nandor Benno, Povarny Magdonla Beresne, Gyula Dalmadi, Katalin Ebinger, Laszlo Forro, Geza Galambos, Felix Hajdu, Istvan Hermecz, Geza Lukacs, Karoly Mozsolits, Szigeti Katalin Polikne, Judit Sebestyen, Tobor Szabo, Zoltan Szeverenyi, Ervin Vajda, Gabor Vankai, Pal Vofely
  • Process for the preparation of prostaglandin E1
    Patent number: 6069269
    Abstract: New process for the preparation of prostaglandin E1 of formula (I) starting from the compound of formula (II).
    Type: Grant
    Filed: September 18, 1998
    Date of Patent: May 30, 2000
    Assignee: CHINOIN Gyogyszer es Vegyeszeti
    Inventors: Gyula Dalmadi, Felix Hajdu, Istvan Hermecz, Karoly Mozsolits, Tibor Szabo, Zoltan Szeverenyi, Ervin Vajda
  • Process for the preparation of 13,14-dihydro-15(R)-17-phenyl-18,19,20-trinor-PGF.sub.2.alpha. isopropyl ester
    Patent number: 5466833
    Abstract: The invention relates to a novel process for the preparation of 13,14-dihydro-15 (R)-17-phenyl-18,19,20-trinor-PGF.sub.2.alpha. isopropyl ester of the formula (I)--wherein R stands for saturated or unsaturated straight, branched or cyclic C.sub.
    Type: Grant
    Filed: October 6, 1994
    Date of Patent: November 14, 1995
    Assignees: Kabi Pharmacia AB, Chinoin Ltd.
    Inventors: Jozsef Ivanics, Tibor Szabo, Istvan Hermecz, Gyula Dalmadi, Jozsefne Ivanics, Gaborne Kovacs, Resul Bahram
  • Process for the preparation of diacyl-dianhydro hexitols
    Patent number: 4820852
    Abstract: The subject of the invention is an improved process for the industrial scale preparation of the compounds of the formula ##STR1## and salts thereof by acylating the hexitols of the formula (II) with an anhydride of the formula (II) at a temperature of 0.degree.-30.degree. C. in the presence of an organic base and a catalyst of the formula (IV) in a dipolar-aprotic or aprotic solvent.
    Type: Grant
    Filed: March 31, 1988
    Date of Patent: April 11, 1989
    Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara
    Inventors: Tibor Szabo, Ildiko Vidra nee Sandor, Gyula Dalmadi, Judit Kaczmarek nee Sebestyen, Janos ri
  • Derivatives of bicyclic lactols
    Patent number: 4257962
    Abstract: Racemic or optically active compounds with antitumor activity of the formula: ##STR1## wherein X is oxygen or sulfur;R.sup.1 is hydrogen, C.sub.1 to C.sub.4 alkanoyl, benzoyl or phenyl-substituted benzoyl;R.sup.2 is hydrogen or C.sub.1 to C.sub.4 alkanoyl;R.sup.3 is C.sub.2 to C.sub.40 straight or branched chain alkyl substituted by hydroxy, epoxy, amino, C.sub.1 to C.sub.6 alkylamino, C.sub.1 to C.sub.6 dialkylamino, C.sub.1 to C.sub.6 alkanoyloxy or, C.sub.1 to C.sub.4 alkoxycarbonyl; cyclohexyl, phenyl unsubstituted or substituted by halogen, amino, C.sub.1 to C.sub.4 alkyl-substituted amino, C.sub.1 to C.sub.4 alkoxy, nitro, or hydroxy; C.sub.1 to C.sub.6 alkanoyl; allyl or phenyl-C.sub.1 to C.sub.4 alkyl unsubstituted or substituted by a C.sub.2 to C.sub.6 alkene group; or where X is sulfur R.sup.3 is as defined above or is C.sub.1 to C.sub.40 straight or branched chain alkyl; and.about. represents the exo- or endo-steric position in the ring and indicates an .alpha.- or .beta.
    Type: Grant
    Filed: September 15, 1978
    Date of Patent: March 24, 1981
    Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.
    Inventors: Tibor Szabo, Laszlo Institoris, Gabor Kovacs, Gyula Dalmadi, Bela Koszegi, Istvan Stadler